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Mammalian Phenotype (MP): decreased T cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + + + 9:   mammalian phenotype [MP:0000001] <29>
+ + + + + + + 7:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + + + + 7:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + + + 6:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + + + + + 6:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ + + + + 5:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
+ + + + + 5:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)
+ + + + 4:   abnormal mononuclear cell morphology [MP:0008247] <2>(33|57) (41|28|14)
+ + + + 4:   abnormal leukocyte morphology [MP:0008246] <4>(36|62) (47|29|15)
+ + + + 4:   abnormal hematopoietic cell number [MP:0011180] <7>(34|57) (43|29|13)
+ + + 3:   decreased hematopoietic cell number [MP:0011182] <5>(21|34) (27|21|11)
+ + + 3:   abnormal lymphocyte morphology [MP:0002619] <5>(27|46) (33|26|14)
+ + + 3:   abnormal leukocyte cell number [MP:0000217] <8>(29|49) (37|25|12)
+ + 2:   abnormal T cell morphology [MP:0008037] <9>(14|25) (18|19|11)
+ + 2:   abnormal lymphocyte cell number [MP:0000717] <6>(18|38) (25|21|9)
+ + 2:   decreased leukocyte cell number [MP:0000221] <5>(17|28) (24|18|10)
+ 1:   abnormal T cell number [MP:0006387] <11>(8|22) (16|15|7)
+ 1:   decreased lymphocyte cell number [MP:0005016] <5>(16|28) (22|16|7)
0:   decreased T cell number [MP:0005018] <12>(8|15) (13|11|5)
- 1:   decreased gamma-delta T cell number [MP:0008347] <6>(0|0) (0|0|0)
- 1:   decreased double-negative T cell number [MP:0005089] <5>(0|0) (2|3|1)
- 1:   absent T cells [MP:0008070] <4>(0|0) (0|0|0)
- 1:   decreased NK T cell number [MP:0008040] <4>(0|0) (0|0|0)
- 1:   decreased T-helper cell number [MP:0013764] <4>(0|0) (0|0|0)
- 1:   decreased thymocyte number [MP:0000715] <4>(2|4) (4|2|1)
- 1:   decreased alpha-beta T cell number [MP:0012765] <3>(3|6) (3|3|1)
- 1:   decreased memory T cell number [MP:0008050] <2>(0|0) (0|0|0)
- 1:   decreased regulatory T cell number [MP:0004974] <2>(0|0) (0|0|0)
- 1:   decreased activated T cell number [MP:0001830](1|0) (1|0|0)
- 1:   decreased double-positive T cell number [MP:0005092](1|2) (1|2|1)
- 1:   decreased single-positive T cell number [MP:0008083](1|2) (2|3|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Integrin domains0.0003308Direct
Integrin alpha N-terminal domain0.0008862Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.001593Inherited
SH2 domain0.24Inherited
E2F-DP heterodimerization region0.3069Inherited
MHC antigen-recognition domain0.3778Inherited
Cysteine-rich domain0.8572Inherited
DEATH domain0.9256Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
Proteasome subunits0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00000005418Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0000003261Direct
Integrin domains0.0002204Direct
Interferon regulatory factor0.0002916Direct
SH2 domain0.1888Inherited
SH3-domain0.2475Inherited
Cell cycle transcription factor e2f-dp0.2628Inherited
E2F dimerization segment0.2628Inherited
C1 set domains (antibody constant domain-like)0.2753Inherited
MHC antigen-recognition domain0.3275Inherited
ets domain0.4037Inherited
Pointed domain0.5048Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.5605Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Integrin domains0.0001715Direct
Integrin alpha N-terminal domain0.0004802Direct
p53-like transcription factors0.000807Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0008949Direct
beta-beta-alpha zinc fingers0.005531Inherited
Protein kinase-like (PK-like)0.1584Inherited
SH2 domain0.2005Inherited
Acyl-CoA N-acyltransferases (Nat)0.2486Inherited
SH3-domain0.2595Inherited
E2F-DP heterodimerization region0.2632Inherited
MHC antigen-recognition domain0.3317Inherited
Cysteine-rich domain0.8266Inherited
DEATH domain0.9012Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000000362Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.000003454Direct
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.0004404Direct
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.0004404Direct
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.009427Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.01189Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1872Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.2632Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3317Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.4Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.0004404Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.000479Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000479Direct
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.01189Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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