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Mammalian Phenotype (MP): abnormal response to infection

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
0:   abnormal response to infection [MP:0005025] <2>(18|31) (21|17|5)
- 1:   altered susceptibility to infection [MP:0001793] <8>(18|31) (21|17|5)
- 1:   sepsis [MP:0005044](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
4-helical cytokines0.0002034Direct
Triple coiled coil domain of C-type lectins0.0005413Direct
DEATH domain0.0008236Direct
p53-like transcription factors0.001718Inherited
C-type lectin-like0.002796Inherited
Toll/Interleukin receptor TIR domain0.004035Inherited
PGBD-like0.007263Inherited
STAT0.01611Inherited
Transcription factor STAT-4 N-domain0.01611Inherited
RNI-like0.02703Inherited
Hemopexin-like domain0.02865Inherited
dsRNA-binding domain-like0.03729Inherited
MHC antigen-recognition domain0.09703Inherited
Alpha-macroglobulin receptor domain0.1447Inherited
Immunoglobulin0.1806Inherited
TNF receptor-like0.2926Inherited
Caspase-like0.4385Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Interferon regulatory factor0.0000000019Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.0000003045Direct
Triple coiled coil domain of C-type lectins0.0003532Direct
C-type lectin domain0.0003623Direct
Netrin-like domain (NTR/C345C module)0.001277Inherited
MMP N-terminal domain0.005042Inherited
Matrix metalloproteases, catalytic domain0.005042Inherited
Caspase recruitment domain, CARD0.005042Inherited
Toll/Interleukin receptor TIR domain0.005599Inherited
DEATH domain, DD0.007802Inherited
Interleukin 17F, IL-17F0.008657Inherited
STAT DNA-binding domain0.0115Inherited
Interferons/interleukin-10 (IL-10)0.0115Inherited
STAT0.0115Inherited
Transcription factor STAT-4 N-domain0.0115Inherited
Long-chain cytokines0.0115Inherited
Short-chain cytokines0.02135Inherited
Hemopexin-like domain0.02135Inherited
Eukaryotic proteases0.02321Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.02437Inherited
Double-stranded RNA-binding domain (dsRBD)0.0425Inherited
C1 set domains (antibody constant domain-like)0.04497Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.05062Inherited
Fibronectin type II module0.06477Inherited
Interleukin-1 (IL-1)0.06477Inherited
MHC antigen-recognition domain0.07886Inherited
Complement components0.1205Inherited
Alpha-macroglobulin receptor domain0.1205Inherited
TNF receptor-like0.1726Inherited
Caspase catalytic domain0.3313Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
4-helical cytokines0.0001029Direct
Triple coiled coil domain of C-type lectins0.0002871Direct
DEATH domain0.0004451Direct
p53-like transcription factors0.000969Direct
C-type lectin-like0.001616Inherited
Toll/Interleukin receptor TIR domain0.002381Inherited
PGBD-like0.004457Inherited
STAT0.0104Inherited
Transcription factor STAT-4 N-domain0.0104Inherited
RNI-like0.01818Inherited
Hemopexin-like domain0.01937Inherited
dsRNA-binding domain-like0.02575Inherited
Trypsin-like serine proteases0.02812Inherited
MHC antigen-recognition domain0.07299Inherited
TNF-like0.08615Inherited
Alpha-macroglobulin receptor domain0.1141Inherited
Immunoglobulin0.1458Inherited
Integrin alpha N-terminal domain0.1553Inherited
TNF receptor-like0.2499Inherited
Caspase-like0.3909Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.0002871Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.004457Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.005841Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.006844Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0104Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0104Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0104Inherited
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.01155Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.01937Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.04691Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.04691Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.06092Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1065Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1141Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.1141Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1553Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0104Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0104Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01937Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.04691Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.06092Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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