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Mammalian Phenotype (MP): abnormal cell differentiation

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   cellular phenotype [MP:0005384] <6>(95|116) (103|56|31)
+ 1:   abnormal cell physiology [MP:0005621] <24>(77|96) (84|46|25)
0:   abnormal cell differentiation [MP:0005076] <25>(11|17) (13|5|4)
- 1:   abnormal neuron differentiation [MP:0009937] <8>(8|11) (8|2|1)
- 1:   abnormal granulocyte differentiation [MP:0008111] <3>(0|0) (0|0|0)
- 1:   abnormal fat cell differentiation [MP:0011168] <2>(0|0) (0|0|0)
- 1:   abnormal mononuclear cell differentiation [MP:0002445] <2>(0|0) (0|0|0)
- 1:   abnormal osteoblast differentiation [MP:0008395] <2>(0|0) (0|0|0)
- 1:   abnormal dendritic cell differentiation [MP:0008115] <1>(0|0) (0|0|0)
- 1:   abnormal myofibroblast differentiation [MP:0012196] <1>(0|0) (0|0|0)
- 1:   abnormal organ of Corti supporting cell differentiation [MP:0008304] <1>(0|0) (0|0|0)
- 1:   impaired granulosa cell differentiation [MP:0003357] <1>(0|0) (0|0|0)
- 1:   impaired neural crest cell differentiation [MP:0012195] <1>(0|0) (0|0|0)
- 1:   abnormal Bergmann glial cell differentiation [MP:0010388](0|0) (0|0|0)
- 1:   abnormal PP cell differentiation [MP:0009188](0|0) (0|0|0)
- 1:   abnormal airway basal cell differentiation [MP:0011114](0|0) (0|0|0)
- 1:   abnormal enterocyte differentiation [MP:0010159](1|1) (1|0|0)
- 1:   abnormal keratinocyte differentiation [MP:0002656](0|0) (0|0|0)
- 1:   abnormal megakaryocyte differentiation [MP:0000229](0|0) (0|0|0)
- 1:   abnormal mesenchymal cell differentiation involved in lung development [MP:0011145](0|0) (0|0|0)
- 1:   abnormal myoblast differentiation [MP:0011808](0|0) (0|0|0)
- 1:   abnormal osteoclast differentiation [MP:0008396](0|1) (0|0|0)
- 1:   abnormal pancreatic alpha cell differentiation [MP:0009179](0|0) (0|0|0)
- 1:   abnormal pancreatic beta cell differentiation [MP:0009175](0|1) (1|0|0)
- 1:   abnormal pancreatic delta cell differentiation [MP:0009183](0|0) (0|0|0)
- 1:   abnormal pancreatic epsilon cell differentiation [MP:0009193](0|0) (0|0|0)
- 1:   abnormal vascular endothelial cell differentiation [MP:0003543](0|0) (0|0|0)
- 1:   impaired luteal cell differentiation [MP:0001133](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Homeodomain-like0.00006106Direct
SH2 domain0.0001161Direct
HLH, helix-loop-helix DNA-binding domain0.0001921Direct
Fibronectin type III0.002676Inherited
Galactose-binding domain-like0.01346Inherited
SNARE fusion complex0.06475Inherited
Rhodanese/Cell cycle control phosphatase0.1753Inherited
SAM/Pointed domain0.2449Inherited
RNA-binding domain, RBD0.7837Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Other IPT/TIG domains0Direct
Retinoblastoma tumor suppressor domains0Direct
RUNT domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Lamin A/C globular tail domain0Direct
Homeodomain0.00005538Direct
SH2 domain0.0001296Direct
HLH, helix-loop-helix DNA-binding domain0.0002267Direct
Fibronectin type III0.003973Inherited
Ephrin receptor ligand binding domain0.005653Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.006709Inherited
Long-chain cytokines0.02523Inherited
SAM (sterile alpha motif) domain0.05801Inherited
SNARE fusion complex0.05952Inherited
Forkhead DNA-binding domain0.08666Inherited
Cell cycle control phosphatase, catalytic domain0.103Inherited
Canonical RBD0.5876Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Homeodomain-like0.00002887Direct
SH2 domain0.00005691Direct
HLH, helix-loop-helix DNA-binding domain0.00009679Direct
p53-like transcription factors0.0006046Direct
Fibronectin type III0.001542Inherited
Galactose-binding domain-like0.008578Inherited
SNARE fusion complex0.04697Inherited
Rhodanese/Cell cycle control phosphatase0.1409Inherited
SAM/Pointed domain0.2051Inherited
"Winged helix" DNA-binding domain0.5752Inherited
RNA-binding domain, RBD0.7478Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0002812Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0005035Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.003984Inherited
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0161Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.00007481Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.000533Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000533Direct
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.004972Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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