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Mammalian Phenotype (MP): abnormal response to injury

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
0:   abnormal response to injury [MP:0005164] <10>(13|22) (17|11|7)
- 1:   altered response to myocardial infarction [MP:0000343] <6>(0|0) (0|0|0)
- 1:   abnormal wound healing [MP:0005023] <5>(4|6) (4|4|1)
- 1:   decreased susceptibility to injury [MP:0005166] <4>(3|2) (5|1|0)
- 1:   increased susceptibility to injury [MP:0005165] <3>(0|1) (0|0|0)
- 1:   altered response of heart to induced stress [MP:0004484] <2>(0|0) (0|0|0)
- 1:   altered response to CNS ischemic injury [MP:0003075] <2>(4|4) (6|1|0)
- 1:   altered response to retinal ischemic injury [MP:0012048] <2>(0|0) (0|0|0)
- 1:   altered susceptibility to kidney reperfusion injury [MP:0004040] <2>(3|3) (3|1|0)
- 1:   abnormal Wallerian degeneration [MP:0010653] <1>(0|0) (0|0|0)
- 1:   abnormal susceptibility to injury induced morbidity/mortality [MP:0020344](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
TSP type-3 repeat0.0000408Direct
FnI-like domain0.0002907Direct
Kringle-like0.0005706Direct
Integrin domains0.000999Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.001008Inherited
Toll/Interleukin receptor TIR domain0.001923Inherited
Plakin repeat0.003223Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01157Inherited
Riboflavin synthase domain-like0.01157Inherited
Plexin repeat0.01462Inherited
Flavoproteins0.04072Inherited
Sema domain0.1095Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Thrombospondin C-terminal domain0.00002832Direct
TSP type-3 repeat0.00002832Direct
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A0.0002883Direct
Matrix metalloproteases, catalytic domain0.0004147Direct
Gelsolin-like0.0005326Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0007598Direct
Integrin domains0.0007645Direct
Hemopexin-like domain0.0008199Direct
LIM domain0.0008806Direct
Plakin repeat0.002456Inherited
Cytochrome p450 reductase N-terminal domain-like0.002745Inherited
Toll/Interleukin receptor TIR domain0.004807Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.009003Inherited
NADPH-cytochrome p450 reductase-like0.009003Inherited
Fibronectin type II module0.01031Inherited
Penta-EF-hand proteins0.01159Inherited
Plexin repeat0.01356Inherited
Actin/HSP700.03704Inherited
Caspase catalytic domain0.05107Inherited
TNF receptor-like0.05308Inherited
Sema domain0.1034Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
TSP type-3 repeat0.00001897Direct
FnI-like domain0.0001495Direct
Kringle-like0.0003025Direct
Integrin domains0.0005453Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0005507Direct
Hemopexin-like domain0.0005969Direct
Toll/Interleukin receptor TIR domain0.00109Inherited
EGF/Laminin0.00162Inherited
Plakin repeat0.001881Inherited
Riboflavin synthase domain-like0.007314Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.007314Inherited
Plexin repeat0.009374Inherited
Flavoproteins0.02832Inherited
Caspase-like0.04424Inherited
Sema domain0.08364Inherited
TNF receptor-like0.094Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    56112,54427
  • 56112 - Protein kinase-like (PK-like)
  • 54427 - NTF2-like
  • 0Direct
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.00001897Direct
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00001897Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00007179Direct
    55753,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.0002143Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.0002143Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0.0007962Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.007505Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.009103Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.08364Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.000007038Direct
    103647,103647,49899
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00001897Direct
    103647,103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.00001897Direct
    82754,55753,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.0002143Direct
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.0004196Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0007962Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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