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Mammalian Phenotype (MP): abnormal cholesterol homeostasis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + 2:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ 1:   abnormal lipid homeostasis [MP:0002118] <9>(25|29) (29|17|10)
0:   abnormal cholesterol homeostasis [MP:0005278] <1>(11|12) (13|10|8)
- 1:   abnormal cholesterol level [MP:0003947] <5>(11|12) (13|10|8)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Apolipoprotein A-I0.00003627Direct
Multidrug efflux transporter AcrB transmembrane domain0.000908Direct
Serum albumin-like0.001311Inherited
YWTD domain0.0722Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1141Inherited
Riboflavin synthase domain-like0.1141Inherited
Flavoproteins0.1141Inherited
alpha/beta-Hydrolases0.1921Inherited
Bet v1-like0.2266Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.2266Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Apolipoprotein A-I0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.00002093Direct
NADPH-cytochrome p450 reductase-like0.00002093Direct
Phoshoinositide 3-kinase (PI3K) helical domain0.0002671Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0008344Direct
Serum albumin-like0.0008364Direct
YWTD domain0.05604Inherited
Pancreatic lipase, N-terminal domain0.2222Inherited
Sir2 family of transcriptional regulators0.3225Inherited
Fatty acid binding protein-like0.5114Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Apolipoprotein A-I0.00001675Direct
Multidrug efflux transporter AcrB transmembrane domain0.0004933Direct
Serum albumin-like0.0007281Direct
YWTD domain0.05298Inherited
Riboflavin synthase domain-like0.08757Inherited
Flavoproteins0.08757Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.08757Inherited
alpha/beta-Hydrolases0.1562Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.188Inherited
Bet v1-like0.188Inherited
DHS-like NAD/FAD-binding domain0.3128Inherited
Lipocalins0.5137Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.000225Direct
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.0007281Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.0009251Direct
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.03176Inherited
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.08757Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.08757Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.1436Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.1436Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.3632Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.000225Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.001723Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.03176Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.1436Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.1436Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.1436Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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