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Mammalian Phenotype (MP): muscle phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   muscle phenotype [MP:0005369] <2>(49|57) (54|37|28)
- 1:   abnormal muscle physiology [MP:0002106] <23>(25|33) (27|16|11)
- 1:   abnormal muscle morphology [MP:0002108] <16>(28|31) (31|22|21)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Troponin coil-coiled subunits0Direct
Lamin A/C globular tail domain0Direct
Protein kinase-like (PK-like)0.0000001293Direct
Glucocorticoid receptor-like (DNA-binding domain)0.000006205Direct
EGF/Laminin0.00001587Direct
Nuclear receptor ligand-binding domain0.00009298Direct
p53-like transcription factors0.0001108Direct
Growth factor receptor domain0.0001444Direct
Spectrin repeat0.0002428Direct
IP3 receptor type 1 binding core, domain 20.000387Direct
SMAD MH1 domain0.0004152Direct
MIR domain0.0004152Direct
TB module/8-cys domain0.0004152Direct
Riboflavin synthase domain-like0.0008489Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0008489Direct
Calponin-homology domain, CH-domain0.0008597Direct
alpha-catenin/vinculin-like0.00163Inherited
Notch domain0.001688Inherited
Calcium ATPase, transduction domain A0.002903Inherited
Myosin rod fragments0.003424Inherited
Calcium ATPase, transmembrane domain M0.00605Inherited
SRF-like0.006968Inherited
Flavoproteins0.0138Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.01621Inherited
Homeodomain-like0.01749Inherited
HLH, helix-loop-helix DNA-binding domain0.01982Inherited
Cystine-knot cytokines0.02845Inherited
TIMP-like0.05654Inherited
Spermadhesin, CUB domain0.06665Inherited
Inhibitor of apoptosis (IAP) repeat0.06674Inherited
E set domains0.06843Inherited
Voltage-gated potassium channels0.07443Inherited
Transducin (alpha subunit), insertion domain0.08683Inherited
WW domain0.1093Inherited
Actin-like ATPase domain0.1258Inherited
(Trans)glycosidases0.1428Inherited
Clavaminate synthase-like0.1613Inherited
BPTI-like0.1682Inherited
Nucleotide cyclase0.1821Inherited
Thyroglobulin type-1 domain0.1953Inherited
B-box zinc-binding domain0.2163Inherited
POZ domain0.3147Inherited
Kazal-type serine protease inhibitors0.3222Inherited
Lipocalins0.4355Inherited
Metalloproteases ("zincins"), catalytic domain0.4693Inherited
"Winged helix" DNA-binding domain0.5521Inherited
RING/U-box0.5917Inherited
L domain-like0.8361Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Troponin T0Direct
Retinoblastoma tumor suppressor domains0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Protein kinases, catalytic subunit0.000003003Direct
Spectrin repeat0.00003992Direct
EGF-type module0.00004358Direct
Nuclear receptor0.00004652Direct
L domain0.00005975Direct
Meta-cation ATPase, catalytic domain P0.00008325Direct
Nuclear receptor ligand-binding domain0.00009845Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000256Direct
SMAD MH1 domain0.0003109Direct
MIR domain0.0003109Direct
TB module/8-cys domain0.0003109Direct
SMAD domain0.0003109Direct
Calcium ATPase, transmembrane domain M0.0004421Direct
Calponin-homology domain, CH-domain0.0008595Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0009041Direct
Notch domain0.001241Inherited
NADPH-cytochrome p450 reductase-like0.001241Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001241Inherited
Growth factor receptor domain0.001334Inherited
Calcium ATPase, transduction domain A0.002572Inherited
Myosin rod fragments0.002897Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.004662Inherited
SRF-like0.005282Inherited
Paired domain0.007158Inherited
Homeodomain0.008848Inherited
alpha-catenin/vinculin0.01646Inherited
Forkhead DNA-binding domain0.01836Inherited
Erythroid transcription factor GATA-10.021Inherited
HLH, helix-loop-helix DNA-binding domain0.02318Inherited
Laminin-type module0.0234Inherited
Tetramerization domain of potassium channels0.0234Inherited
I set domains0.02578Inherited
Plakin repeat0.03375Inherited
Inhibitor of apoptosis (IAP) repeat0.03375Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0447Inherited
Spermadhesin, CUB domain0.06557Inherited
Voltage-gated potassium channels0.06813Inherited
LIM domain0.06963Inherited
Transducin (alpha subunit), insertion domain0.07872Inherited
ZZ domain0.08577Inherited
Transforming growth factor (TGF)-beta0.09309Inherited
WW domain0.1059Inherited
Small Kunitz-type inhibitors & BPTI-like toxins0.1541Inherited
Adenylyl and guanylyl cyclase catalytic domain0.1733Inherited
Thyroglobulin type-1 domain0.1842Inherited
B-box zinc-binding domain0.2117Inherited
EF-hand modules in multidomain proteins0.2514Inherited
Ovomucoid domain III-like0.2867Inherited
Fatty acid binding protein-like0.3602Inherited
28-residue LRR0.4023Inherited
Phosphotyrosine-binding domain (PTB)0.5756Inherited
Ngr ectodomain-like0.9342Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Troponin coil-coiled subunits0Direct
Lamin A/C globular tail domain0Direct
Protein kinase-like (PK-like)0.00000005119Direct
Glucocorticoid receptor-like (DNA-binding domain)0.000002673Direct
EGF/Laminin0.000007065Direct
Nuclear receptor ligand-binding domain0.00004466Direct
p53-like transcription factors0.00005401Direct
Growth factor receptor domain0.00007196Direct
Spectrin repeat0.0001234Direct
IP3 receptor type 1 binding core, domain 20.0002018Direct
TB module/8-cys domain0.0002178Direct
MIR domain0.0002178Direct
SMAD MH1 domain0.0002178Direct
Riboflavin synthase domain-like0.0004595Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0004595Direct
Calponin-homology domain, CH-domain0.0004661Direct
alpha-catenin/vinculin-like0.000917Direct
TSP type-3 repeat0.0009513Direct
Notch domain0.0009513Direct
Calcium ATPase, transduction domain A0.001682Inherited
Myosin rod fragments0.001999Inherited
Calcium ATPase, transmembrane domain M0.00366Inherited
SRF-like0.004263Inherited
Flavoproteins0.008828Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.01048Inherited
Homeodomain-like0.0114Inherited
dsRNA-binding domain-like0.0125Inherited
HLH, helix-loop-helix DNA-binding domain0.01299Inherited
Cystine-knot cytokines0.01924Inherited
Plakin repeat0.02833Inherited
TIMP-like0.04044Inherited
Spermadhesin, CUB domain0.04846Inherited
Inhibitor of apoptosis (IAP) repeat0.04854Inherited
E set domains0.04995Inherited
Voltage-gated potassium channels0.05471Inherited
Transducin (alpha subunit), insertion domain0.06463Inherited
WW domain0.08346Inherited
Actin-like ATPase domain0.09755Inherited
(Trans)glycosidases0.1123Inherited
Clavaminate synthase-like0.1286Inherited
BPTI-like0.1345Inherited
Nucleotide cyclase0.1471Inherited
Thyroglobulin type-1 domain0.1591Inherited
B-box zinc-binding domain0.1784Inherited
Intermediate filament protein, coiled coil region0.2649Inherited
POZ domain0.2706Inherited
Kazal-type serine protease inhibitors0.278Inherited
Lipocalins0.3882Inherited
Metalloproteases ("zincins"), catalytic domain0.4215Inherited
"Winged helix" DNA-binding domain0.5053Inherited
RING/U-box0.5458Inherited
Family A G protein-coupled receptor-like0.7248Inherited
L domain-like0.804Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    55486,49854
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    49265,56112
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.000007497Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.000007779Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.00004021Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00004021Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.00006327Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00006412Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0001732Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.0002018Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.0002018Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.000917Direct
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.0009513Direct
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0009513Direct
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0.0009513Direct
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.00188Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.003263Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.00366Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.00366Inherited
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.00366Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.00366Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.004263Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.007764Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.01048Inherited
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0.01352Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01352Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01352Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.01466Inherited
    100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.02833Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.04913Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04913Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2904Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.3245Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.3729Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,49854,57196
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    49854,49854,57196
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0Direct
    55486,49854,49854
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    82109,100909,49899
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    48726,49265,56112
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00004021Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00004071Direct
    47220,47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.0002018Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.0002018Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0002928Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0009513Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0009513Direct
    103647,103647,49899
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0009513Direct
    103647,103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.0009513Direct
    90257,90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.0009513Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.001955Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.001955Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00366Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00366Inherited
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.004263Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.01048Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.01053Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.0116Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01352Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01352Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.01927Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1052Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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