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Mammalian Phenotype (MP): liver/biliary system phenotype

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   liver/biliary system phenotype [MP:0005370] <2>(37|39) (41|19|10)
- 1:   abnormal hepatobiliary system morphology [MP:0002138] <6>(25|32) (28|15|5)
- 1:   abnormal hepatobiliary system physiology [MP:0002139] <4>(16|14) (16|10|7)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Thioesterase/thiol ester dehydrase-isomerase0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hairpin loop containing domain-like0Direct
Nuclear receptor ligand-binding domain0.000002946Direct
(Trans)glycosidases0.00002773Direct
Glucocorticoid receptor-like (DNA-binding domain)0.000511Direct
Acyl-CoA dehydrogenase NM domain-like0.0006138Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.0006138Direct
p53-like transcription factors0.0008506Direct
STAT0.0008913Direct
Transcription factor STAT-4 N-domain0.0008913Direct
Flavoproteins0.0008913Direct
Families 57/38 glycoside transferase middle domain0.001008Inherited
4-helical cytokines0.001523Inherited
HMA, heavy metal-associated domain0.004685Inherited
DHS-like NAD/FAD-binding domain0.005076Inherited
Alpha-macroglobulin receptor domain0.008722Inherited
Terpenoid cyclases/Protein prenyltransferases0.009201Inherited
Kringle-like0.01462Inherited
Multidrug efflux transporter AcrB transmembrane domain0.01637Inherited
Bet v1-like0.01795Inherited
SH2 domain0.02434Inherited
TNF receptor-like0.02512Inherited
DEATH domain0.0333Inherited
ABC transporter transmembrane region0.04044Inherited
Riboflavin synthase domain-like0.05632Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.05632Inherited
Leucine zipper domain0.0649Inherited
Cyclin-like0.085Inherited
YWTD domain0.1186Inherited
C-type lectin-like0.1241Inherited
WW domain0.1289Inherited
lambda repressor-like DNA-binding domains0.1296Inherited
A DNA-binding domain in eukaryotic transcription factors0.169Inherited
Trypsin-like serine proteases0.3806Inherited
Family A G protein-coupled receptor-like0.8036Inherited
Homeodomain-like0.8137Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Nuclear receptor ligand-binding domain0.000002459Direct
Nuclear receptor0.00000478Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0005994Direct
STAT DNA-binding domain0.0005994Direct
Transcription factor STAT-4 N-domain0.0005994Direct
Sir2 family of transcriptional regulators0.0005994Direct
STAT0.0005994Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0005994Direct
NADPH-cytochrome p450 reductase-like0.0006665Direct
alpha-mannosidase0.0006665Direct
alpha-mannosidase, domain 20.0006665Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0006665Direct
Rel/Dorsal transcription factors, DNA-binding domain0.001008Inherited
HMA, heavy metal-associated domain0.003279Inherited
Fatty acid binding protein-like0.003405Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.006273Inherited
Complement components0.006415Inherited
Alpha-macroglobulin receptor domain0.006415Inherited
DEATH domain, DD0.00673Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.009758Inherited
Erythroid transcription factor GATA-10.01248Inherited
ABC transporter ATPase domain-like0.01411Inherited
TNF receptor-like0.02Inherited
SH2 domain0.02309Inherited
p120GAP domain-like0.03208Inherited
Kringle modules0.03533Inherited
Forkhead DNA-binding domain0.03699Inherited
ABC transporter transmembrane region0.04527Inherited
Leucine zipper domain0.05826Inherited
YWTD domain0.1029Inherited
WW domain0.1159Inherited
A DNA-binding domain in eukaryotic transcription factors0.1503Inherited
Eukaryotic proteases0.401Inherited
Chaperone J-domain0.4116Inherited
Rhodopsin-like0.6401Inherited
Homeodomain0.9615Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
Hairpin loop containing domain-like0Direct
Nuclear receptor ligand-binding domain0.000001244Direct
(Trans)glycosidases0.00001272Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0002707Direct
Acyl-CoA dehydrogenase NM domain-like0.0003263Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.0003263Direct
p53-like transcription factors0.0004606Direct
STAT0.0004831Direct
Flavoproteins0.0004831Direct
Transcription factor STAT-4 N-domain0.0004831Direct
Families 57/38 glycoside transferase middle domain0.0005505Direct
Protein kinase-like (PK-like)0.0005688Direct
4-helical cytokines0.0008537Direct
HMA, heavy metal-associated domain0.002792Inherited
DHS-like NAD/FAD-binding domain0.00304Inherited
Alpha-macroglobulin receptor domain0.005392Inherited
Terpenoid cyclases/Protein prenyltransferases0.005709Inherited
Kringle-like0.009375Inherited
Multidrug efflux transporter AcrB transmembrane domain0.01059Inherited
Bet v1-like0.01169Inherited
SH2 domain0.01623Inherited
TNF receptor-like0.0168Inherited
DEATH domain0.02281Inherited
ABC transporter transmembrane region0.02812Inherited
Riboflavin synthase domain-like0.04026Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.04026Inherited
Leucine zipper domain0.04711Inherited
Cyclin-like0.06312Inherited
EGF/Laminin0.06533Inherited
Insulin-like0.07407Inherited
YWTD domain0.09132Inherited
C-type lectin-like0.09605Inherited
WW domain0.1002Inherited
lambda repressor-like DNA-binding domains0.1008Inherited
A DNA-binding domain in eukaryotic transcription factors0.1352Inherited
Trypsin-like serine proteases0.3344Inherited
Chaperone J-domain0.3794Inherited
Family A G protein-coupled receptor-like0.769Inherited
Homeodomain-like0.7798Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00001272Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.0003263Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0004831Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0004831Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0004831Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0.0005505Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0008Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.001367Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.004221Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.01805Inherited
    103473,100895
  • 103473 - MFS general substrate transporter
  • 100895 - Kazal-type serine protease inhibitors
  • 0.01954Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02812Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.07167Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.07198Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.2531Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0004831Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0004831Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.002687Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.009141Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.01954Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.01954Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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