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Mammalian Phenotype (MP): homeostasis/metabolism phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
- 1:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
- 1:   abnormal metabolism [MP:0005266] <21>(26|21) (30|11|3)
- 1:   wounding [MP:0013027] <17>(0|0) (0|0|0)
- 1:   abnormal response to injury [MP:0005164] <10>(13|22) (17|11|7)
- 1:   abnormal physiological response to xenobiotic [MP:0008872] <3>(6|6) (9|2|0)
- 1:   amyloidosis [MP:0000604] <2>(3|5) (4|2|1)
- 1:   abnormal xenobiotic pharmacokinetics [MP:0008875] <1>(2|2) (2|1|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
HMA, heavy metal-associated domain0Direct
WGR domain-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Ammonium transporter0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Pseudouridine synthase0Direct
CoA-dependent acyltransferases0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Uracil-DNA glycosylase-like0Direct
DNA-glycosylase0Direct
Metallothionein0Direct
Riboflavin synthase domain-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
GLA-domain0Direct
Anaphylotoxins (complement system)0Direct
Radical SAM enzymes0Direct
Synuclein0Direct
FAS1 domain0Direct
Resistin0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Lamin A/C globular tail domain0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Lipoxigenase0Direct
Flavoproteins0Direct
p53 tetramerization domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Notch domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Transferrin receptor-like dimerisation domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Family A G protein-coupled receptor-like0.000006755Direct
Cytochrome P4500.0001472Direct
Protein kinase-like (PK-like)0.0006621Direct
Nuclear receptor ligand-binding domain0.0007265Direct
p53-like transcription factors0.0007776Direct
Hormone receptor domain0.001853Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.003841Inherited
ABC transporter transmembrane region0.004431Inherited
alpha/beta-Hydrolases0.01042Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.0148Inherited
Acyl-CoA dehydrogenase NM domain-like0.0148Inherited
Glycosyl hydrolase domain0.0148Inherited
4-helical cytokines0.01624Inherited
Glycerol-3-phosphate (1)-acyltransferase0.02069Inherited
Aquaporin-like0.02069Inherited
PLP-dependent transferases0.02193Inherited
PYP-like sensor domain (PAS domain)0.02345Inherited
SMAD MH1 domain0.02456Inherited
TNF receptor-like0.03149Inherited
LDL receptor-like module0.03361Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.03361Inherited
NAD(P)-binding Rossmann-fold domains0.03844Inherited
Inhibitor of apoptosis (IAP) repeat0.04042Inherited
STAT0.04042Inherited
Transcription factor STAT-4 N-domain0.04042Inherited
Lipocalins0.04046Inherited
SMAD/FHA domain0.04955Inherited
Phoshotransferase/anion transport protein0.05Inherited
CBS-domain pair0.05104Inherited
(Trans)glycosidases0.05881Inherited
MFS general substrate transporter0.05984Inherited
DEATH domain0.05984Inherited
KA1-like0.06591Inherited
Calcium-dependent phosphotriesterase0.06591Inherited
Thioesterase/thiol ester dehydrase-isomerase0.06591Inherited
Bet v1-like0.06894Inherited
Insulin-like0.07565Inherited
DHS-like NAD/FAD-binding domain0.07565Inherited
FnI-like domain0.07773Inherited
Cystine-knot cytokines0.08328Inherited
Kringle-like0.08949Inherited
SNF-like0.09701Inherited
TSP type-3 repeat0.1058Inherited
DNA polymerase beta, N-terminal domain-like0.1058Inherited
Serum albumin-like0.1058Inherited
FAD-binding/transporter-associated domain-like0.1058Inherited
Apolipoprotein A-I0.1058Inherited
ACT-like0.1058Inherited
Nuclear receptor coactivator interlocking domain0.1058Inherited
Multidrug efflux transporter AcrB transmembrane domain0.113Inherited
Clc chloride channel0.113Inherited
Thioredoxin-like0.1213Inherited
Integrin domains0.1441Inherited
Calponin-homology domain, CH-domain0.1559Inherited
Transducin (alpha subunit), insertion domain0.1567Inherited
CAD & PB1 domains0.1567Inherited
Putative DNA-binding domain0.1662Inherited
Galactose mutarotase-like0.1662Inherited
Domain of poly(ADP-ribose) polymerase0.1679Inherited
Triple coiled coil domain of C-type lectins0.1679Inherited
Caspase-like0.1814Inherited
ClpP/crotonase0.2093Inherited
Clathrin adaptor appendage domain0.2093Inherited
C-type lectin-like0.2136Inherited
Toll/Interleukin receptor TIR domain0.2252Inherited
Ran binding protein zinc finger-like0.2281Inherited
Cation efflux protein transmembrane domain-like0.2397Inherited
GAT-like domain0.2397Inherited
E set domains0.2802Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.2851Inherited
Heme-dependent peroxidases0.2851Inherited
EGF/Laminin0.3166Inherited
Actin-like ATPase domain0.3198Inherited
TIMP-like0.3364Inherited
GroEL equatorial domain-like0.3413Inherited
DNA repair protein MutS, domain III0.3413Inherited
BRCT domain0.3475Inherited
Periplasmic binding protein-like I0.3605Inherited
YWTD domain0.3629Inherited
PLC-like phosphodiesterases0.3629Inherited
Cytokine0.3669Inherited
Spectrin repeat0.4284Inherited
SH2 domain0.4352Inherited
FAD/NAD(P)-binding domain0.4465Inherited
Alkaline phosphatase-like0.4699Inherited
Plakin repeat0.5055Inherited
Trypsin-like serine proteases0.5351Inherited
Growth factor receptor domain0.5417Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.5419Inherited
HMG-box0.6297Inherited
ENTH/VHS domain0.6408Inherited
Carbonic anhydrase0.642Inherited
PH domain-like0.725Inherited
HLH, helix-loop-helix DNA-binding domain0.7427Inherited
Fibronectin type III0.7585Inherited
Thyroglobulin type-1 domain0.7986Inherited
ADP-ribosylation0.7986Inherited
Metallo-dependent hydrolases0.8233Inherited
Nucleic acid-binding proteins0.8282Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8467Inherited
CCCH zinc finger0.8826Inherited
Intermediate filament protein, coiled coil region0.895Inherited
Cyclin-like0.9019Inherited
Plexin repeat0.972Inherited
SH3-domain0.9775Inherited
Homeodomain-like0.9995Inherited
Immunoglobulin1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Sema domain1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Neurotrophin0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Notch domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Multidomain cupredoxins0Direct
Metallothionein0Direct
5' to 3' exonuclease catalytic domain0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
Retinoblastoma tumor suppressor domains0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
RUNT domain0Direct
DNA ligase0Direct
Chromo barrel domain0Direct
Oligoxyloglucan reducing end-specific cellobiohydrolase0Direct
Neurolysin-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Animal lipoxigenases0Direct
HMA, heavy metal-associated domain0Direct
Cytidylyltransferase0Direct
Erythroid transcription factor GATA-10Direct
gamma-adaptin C-terminal appendage domain-like0Direct
Resistin0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Sir2 family of transcriptional regulators0Direct
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
BAFF receptor-like0Direct
NADPH-cytochrome p450 reductase-like0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
FolH catalytic domain-like0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
GLA-domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Synuclein0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Choline/Carnitine O-acyltransferase0Direct
FAS1 domain0Direct
Tissue inhibitor of metalloproteinases, TIMP0Direct
Sialidases (neuraminidases)0Direct
WGR domain0Direct
Anaphylotoxins (complement system)0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
IP3 receptor type 1 binding core, domain 20Direct
Cu,Zn superoxide dismutase-like0Direct
ATP-dependent DNA ligase catalytic domain0Direct
Carboxylesterase0Direct
p53 tetramerization domain0Direct
Amylase, catalytic domain0Direct
HIT (HINT, histidine triad) family of protein kinase-interacting proteins0Direct
Interleukin-1 (IL-1)0Direct
Transferrin receptor-like dimerisation domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Phenylalanine metabolism regulatory domain0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Ammonium transporter0Direct
Lamin A/C globular tail domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
HCDH C-domain-like0Direct
Apolipoprotein A-I0Direct
Rhodopsin-like0.00002532Direct
Cytochrome P4500.000141Direct
Nuclear receptor ligand-binding domain0.0007184Direct
Short-chain cytokines0.001344Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001344Inherited
Hormone receptor domain0.001504Inherited
Nuclear receptor0.001508Inherited
ABC transporter ATPase domain-like0.002541Inherited
ABC transporter transmembrane region0.003328Inherited
GABA-aminotransferase-like0.01182Inherited
CBS-domain pair0.0173Inherited
Aquaporin-like0.0173Inherited
SMAD MH1 domain0.01991Inherited
SMAD domain0.01991Inherited
Platelet-derived growth factor-like0.01991Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.0295Inherited
LDL receptor-like module0.03183Inherited
STAT DNA-binding domain0.03306Inherited
Pancreatic lipase, N-terminal domain0.03306Inherited
L domain0.03306Inherited
STAT0.03306Inherited
Cytochrome b50.03306Inherited
Transcription factor STAT-4 N-domain0.03306Inherited
Fibronectin type II module0.04246Inherited
TNF receptor-like0.04292Inherited
EGF-type module0.04855Inherited
Lipoxigenase N-terminal domain0.05507Inherited
Fatty acid binding protein-like0.06159Inherited
Insulin-like0.06544Inherited
Anion transport protein, cytoplasmic domain0.06544Inherited
T-box0.07869Inherited
SNF-like0.08753Inherited
Long-chain cytokines0.08753Inherited
CAD domain0.09075Inherited
DNA polymerase beta, N-terminal domain-like0.09075Inherited
Thrombospondin C-terminal domain0.09075Inherited
TSP type-3 repeat0.09075Inherited
Serum albumin-like0.09075Inherited
Nuclear receptor coactivator interlocking domain0.09075Inherited
Caspase catalytic domain0.09555Inherited
Clc chloride channel0.09986Inherited
Meta-cation ATPase, catalytic domain P0.1081Inherited
DEATH domain, DD0.1205Inherited
Integrin domains0.1388Inherited
Transducin (alpha subunit), insertion domain0.1459Inherited
GAT domain0.1476Inherited
Triple coiled coil domain of C-type lectins0.1476Inherited
Kinase associated domain 1, KA10.1476Inherited
Crotonase-like0.1476Inherited
beta-glycanases0.1476Inherited
Adenosine/AMP deaminase0.1476Inherited
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A0.1476Inherited
Domain of poly(ADP-ribose) polymerase0.1476Inherited
Pointed domain0.1488Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1488Inherited
Gelsolin-like0.1488Inherited
Pyrin domain, PYD0.1488Inherited
Calponin-homology domain, CH-domain0.1587Inherited
C-type lectin domain0.1593Inherited
Forkhead DNA-binding domain0.1629Inherited
Matrix metalloproteases, catalytic domain0.187Inherited
Interferon regulatory factor0.193Inherited
Kringle modules0.1948Inherited
PLC-like (P variant)0.1974Inherited
Hemopexin-like domain0.2044Inherited
FHA domain0.2044Inherited
Ran binding protein zinc finger-like0.2179Inherited
Acetyl-CoA synthetase-like0.2179Inherited
Noncollagenous (NC1) domain of collagen IV0.2197Inherited
E2F dimerization segment0.2197Inherited
Cation efflux protein transmembrane domain-like0.2197Inherited
Spectrin repeat0.2199Inherited
Myeloperoxidase-like0.268Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.268Inherited
Toll/Interleukin receptor TIR domain0.2719Inherited
Growth factor receptor domain0.3092Inherited
DNA repair protein MutS, domain III0.3194Inherited
Mammalian PLC0.331Inherited
YWTD domain0.3534Inherited
Phosphotyrosine-binding domain (PTB)0.358Inherited
Poly(ADP-ribose) polymerase, C-terminal domain0.3654Inherited
28-residue LRR0.3706Inherited
Penta-EF-hand proteins0.3968Inherited
Papain-like0.4376Inherited
Pleckstrin-homology domain (PH domain)0.4635Inherited
SH2 domain0.478Inherited
Plakin repeat0.4872Inherited
Chaperone J-domain0.5141Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.5213Inherited
p120GAP domain-like0.5213Inherited
Transforming growth factor (TGF)-beta0.5269Inherited
Caspase recruitment domain, CARD0.5474Inherited
Eukaryotic proteases0.6055Inherited
VHS domain0.6315Inherited
Interferons/interleukin-10 (IL-10)0.6323Inherited
Arylsulfatase0.6323Inherited
Carbonic anhydrase0.6345Inherited
LIM domain0.6426Inherited
HMG-box0.6439Inherited
Actin/HSP700.711Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.7214Inherited
HLH, helix-loop-helix DNA-binding domain0.7815Inherited
PHD domain0.7835Inherited
Thyroglobulin type-1 domain0.7953Inherited
Fibronectin type III0.8106Inherited
G proteins0.8611Inherited
CCCH zinc finger0.879Inherited
Intermediate filament protein, coiled coil region0.9029Inherited
Cyclin0.9602Inherited
Plexin repeat0.9731Inherited
SH3-domain0.9892Inherited
Homeodomain0.992Inherited
Sema domain1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Ammonium transporter0Direct
Lamin A/C globular tail domain0Direct
WGR domain-like0Direct
Metallothionein0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Radical SAM enzymes0Direct
HMA, heavy metal-associated domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Resistin0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Riboflavin synthase domain-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
DNA-glycosylase0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
FAS1 domain0Direct
Lipoxigenase0Direct
Uracil-DNA glycosylase-like0Direct
Synuclein0Direct
p53 tetramerization domain0Direct
Anaphylotoxins (complement system)0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
CoA-dependent acyltransferases0Direct
Flavoproteins0Direct
GLA-domain0Direct
Pseudouridine synthase0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Transferrin receptor-like dimerisation domain0Direct
Notch domain0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Family A G protein-coupled receptor-like0.000002906Direct
Cytochrome P4500.00007341Direct
Protein kinase-like (PK-like)0.0003544Direct
Nuclear receptor ligand-binding domain0.0003893Direct
p53-like transcription factors0.0004188Direct
Hormone receptor domain0.00105Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.002257Inherited
ABC transporter transmembrane region0.002624Inherited
alpha/beta-Hydrolases0.006526Inherited
Glycosyl hydrolase domain0.009496Inherited
Acyl-CoA dehydrogenase NM domain-like0.009496Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.009496Inherited
4-helical cytokines0.0105Inherited
Glycerol-3-phosphate (1)-acyltransferase0.01361Inherited
Aquaporin-like0.01361Inherited
PLP-dependent transferases0.01449Inherited
PYP-like sensor domain (PAS domain)0.01559Inherited
SMAD MH1 domain0.0164Inherited
TNF receptor-like0.02151Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.02303Inherited
LDL receptor-like module0.02303Inherited
NAD(P)-binding Rossmann-fold domains0.02658Inherited
Inhibitor of apoptosis (IAP) repeat0.0281Inherited
STAT0.0281Inherited
Transcription factor STAT-4 N-domain0.0281Inherited
Lipocalins0.02813Inherited
SMAD/FHA domain0.03498Inherited
Phoshotransferase/anion transport protein0.03531Inherited
CBS-domain pair0.03608Inherited
(Trans)glycosidases0.04221Inherited
DEATH domain0.04307Inherited
MFS general substrate transporter0.04307Inherited
Calcium-dependent phosphotriesterase0.04791Inherited
Thioesterase/thiol ester dehydrase-isomerase0.04791Inherited
KA1-like0.04791Inherited
Bet v1-like0.05036Inherited
Insulin-like0.05566Inherited
DHS-like NAD/FAD-binding domain0.05566Inherited
FnI-like domain0.05723Inherited
Cystine-knot cytokines0.0617Inherited
Kringle-like0.06679Inherited
SNF-like0.07298Inherited
Apolipoprotein A-I0.08036Inherited
Serum albumin-like0.08036Inherited
TSP type-3 repeat0.08036Inherited
DNA polymerase beta, N-terminal domain-like0.08036Inherited
ACT-like0.08036Inherited
Nuclear receptor coactivator interlocking domain0.08036Inherited
FAD-binding/transporter-associated domain-like0.08036Inherited
Clc chloride channel0.08664Inherited
Phospholipase A2, PLA20.08664Inherited
Multidrug efflux transporter AcrB transmembrane domain0.08664Inherited
Thioredoxin-like0.09359Inherited
Integrin domains0.1136Inherited
Calponin-homology domain, CH-domain0.124Inherited
Transducin (alpha subunit), insertion domain0.1247Inherited
CAD & PB1 domains0.1247Inherited
Galactose mutarotase-like0.1328Inherited
Putative DNA-binding domain0.1328Inherited
Triple coiled coil domain of C-type lectins0.1343Inherited
Domain of poly(ADP-ribose) polymerase0.1343Inherited
Caspase-like0.1465Inherited
Clathrin adaptor appendage domain0.1717Inherited
ClpP/crotonase0.1717Inherited
Hemopexin-like domain0.1734Inherited
C-type lectin-like0.1758Inherited
Toll/Interleukin receptor TIR domain0.1868Inherited
Acetyl-CoA synthetase-like0.1893Inherited
Ran binding protein zinc finger-like0.1893Inherited
GAT-like domain0.2001Inherited
Cation efflux protein transmembrane domain-like0.2001Inherited
E set domains0.2381Inherited
Heme-dependent peroxidases0.2426Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.2426Inherited
EGF/Laminin0.2725Inherited
t-snare proteins0.2746Inherited
Actin-like ATPase domain0.2757Inherited
TIMP-like0.2913Inherited
Periplasmic binding protein-like II0.2913Inherited
DNA repair protein MutS, domain III0.2961Inherited
GroEL equatorial domain-like0.2961Inherited
BRCT domain0.3022Inherited
Periplasmic binding protein-like I0.3148Inherited
PLC-like phosphodiesterases0.3173Inherited
YWTD domain0.3173Inherited
Cytokine0.3211Inherited
E2F-DP heterodimerization region0.3377Inherited
Spectrin repeat0.3814Inherited
SH2 domain0.3879Inherited
FAD/NAD(P)-binding domain0.3989Inherited
Alkaline phosphatase-like0.4221Inherited
Plakin repeat0.4579Inherited
Chaperone J-domain0.459Inherited
Trypsin-like serine proteases0.488Inherited
Growth factor receptor domain0.4949Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.4951Inherited
HMG-box0.5852Inherited
ENTH/VHS domain0.5967Inherited
Carbonic anhydrase0.598Inherited
EF-hand0.6476Inherited
PH domain-like0.6856Inherited
HLH, helix-loop-helix DNA-binding domain0.7043Inherited
Fibronectin type III0.7206Inherited
TNF-like0.7512Inherited
ADP-ribosylation0.7638Inherited
Thyroglobulin type-1 domain0.7638Inherited
Metallo-dependent hydrolases0.7901Inherited
Nucleic acid-binding proteins0.7954Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8152Inherited
CCCH zinc finger0.8544Inherited
Intermediate filament protein, coiled coil region0.8675Inherited
Cyclin-like0.8752Inherited
Plexin repeat0.9533Inherited
SH3-domain0.9599Inherited
Homeodomain-like0.9865Inherited
P-loop containing nucleoside triphosphate hydrolases0.9903Inherited
Sema domain0.9992Inherited
Immunoglobulin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0Direct
    57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    48403,50044
  • 48403 - Ankyrin repeat
  • 50044 - SH3-domain
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    53187,47672
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    48452,57850
  • 48452 - TPR-like
  • 57850 - RING/U-box
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    52025,53187
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    46565,57938
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 0Direct
    142921,47587
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 0Direct
    88723,47807
  • 88723 - PIN domain-like
  • 47807 - 5' to 3' exonuclease, C-terminal subdomain
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0Direct
    56112,54427
  • 56112 - Protein kinase-like (PK-like)
  • 54427 - NTF2-like
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.001785Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002624Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.009496Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.009496Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.009496Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.01361Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.01923Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02303Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02371Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0281Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0281Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0281Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0281Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.0281Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0281Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.04791Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.05723Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.08036Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.08036Inherited
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.08036Inherited
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.08036Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.08664Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.08664Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.1328Inherited
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0.1343Inherited
    55753,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.1343Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.1343Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.1343Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.159Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1693Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1717Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.1717Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1868Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.2001Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.2001Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.2001Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.2426Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.2426Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.2426Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2746Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.2951Inherited
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0.2961Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2961Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3228Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.3289Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.3377Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.3377Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.3651Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.3855Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.3855Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.4579Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4756Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.5181Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5893Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.6812Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.9967Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.9992Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    52025,53187,47672
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    142921,47587,56399
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    46565,57938,49493
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.003034Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0281Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0281Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0281Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03608Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.04539Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.04791Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.04791Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.04791Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.08036Inherited
    103647,103647,49899
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.08036Inherited
    103647,103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.08036Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.08113Inherited
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.1328Inherited
    82754,55753,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.1343Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.1343Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.2001Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.2001Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2268Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.2426Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.2961Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.2961Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3377Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.6657Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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