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Mammalian Phenotype (MP): embryo phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   embryo phenotype [MP:0005380] <7>(40|54) (46|28|19)
- 1:   abnormal extraembryonic tissue morphology [MP:0002086] <17>(13|18) (16|4|3)
- 1:   abnormal extraembryonic tissue physiology [MP:0004264] <10>(1|3) (2|2|1)
- 1:   abnormal embryonic tissue physiology [MP:0008932] <8>(1|3) (1|2|2)
- 1:   abnormal embryo development [MP:0001672] <5>(9|15) (11|11|5)
- 1:   abnormal embryo morphology [MP:0014134] <4>(23|31) (26|14|12)
- 1:   abnormal visceral endoderm morphology [MP:0011186] <3>(1|2) (1|0|0)
- 1:   abnormal visceral endoderm physiology [MP:0012028] <1>(1|1) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Homeodomain-like0.000000000005832Direct
p53-like transcription factors0.000001881Direct
"Winged helix" DNA-binding domain0.00000669Direct
SMAD MH1 domain0.00006442Direct
Protein kinase-like (PK-like)0.0000814Direct
Bromodomain0.00009958Direct
Growth factor receptor domain0.0001991Direct
BRCT domain0.0003248Direct
HLH, helix-loop-helix DNA-binding domain0.0004438Direct
HMG-box0.0006555Direct
Frizzled cysteine-rich domain0.0006947Direct
SET domain0.0008835Direct
WD40 repeat-like0.001586Inherited
Nucleic acid-binding proteins0.002839Inherited
Notch domain0.003571Inherited
Cystine-knot cytokines0.005328Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.006107Inherited
Cullin repeat-like0.01208Inherited
Cullin homology domain0.02626Inherited
HCP-like0.02626Inherited
SMAD/FHA domain0.02705Inherited
Nuclear receptor ligand-binding domain0.03048Inherited
Cyclin-like0.0347Inherited
DNA clamp0.03482Inherited
Snake toxin-like0.03894Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.06636Inherited
4-helical cytokines0.0848Inherited
Terpenoid cyclases/Protein prenyltransferases0.1022Inherited
Integrin beta tail domain0.1051Inherited
Alpha-macroglobulin receptor domain0.1051Inherited
Histone-fold0.1613Inherited
Ubiquitin-like0.2532Inherited
SAM/Pointed domain0.2743Inherited
Cytokine0.2772Inherited
TIMP-like0.5488Inherited
WW domain0.6511Inherited
Ankyrin repeat0.7216Inherited
PDZ domain-like0.777Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
DNA ligase0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
p53 tetramerization domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Homeodomain0.0000000116Direct
Histone lysine methyltransferases0.000008255Direct
T-box0.00001356Direct
SMAD MH1 domain0.00003882Direct
SMAD domain0.00003882Direct
Growth factor receptor domain0.00005879Direct
Bromodomain0.00006806Direct
HLH, helix-loop-helix DNA-binding domain0.0003701Direct
Frizzled cysteine-rich domain0.0004747Direct
HMG-box0.0004795Direct
DIX domain0.0006301Direct
Extracellular domain of cell surface receptors0.000722Direct
Protein kinases, catalytic subunit0.001058Inherited
Forkhead DNA-binding domain0.001536Inherited
Transforming growth factor (TGF)-beta0.002151Inherited
Paired domain0.002303Inherited
Notch domain0.002404Inherited
L domain0.002679Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.005211Inherited
Erythroid transcription factor GATA-10.007004Inherited
Formate/glycerate dehydrogenases, substrate-binding domain0.008839Inherited
Cullin repeat0.008839Inherited
Tetrahydrofolate dehydrogenase/cyclohydrolase0.008839Inherited
C5 cytosine-specific DNA methylase, DCM0.008839Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0115Inherited
Nuclear receptor0.01725Inherited
Pointed domain0.01983Inherited
Cullin homology domain0.01983Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.01983Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.01983Inherited
Nuclear receptor ligand-binding domain0.02532Inherited
SCF ubiquitin ligase complex WHB domain0.02635Inherited
Integrin beta EGF-like domains0.03614Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.03614Inherited
Formate/glycerate dehydrogenases, NAD-domain0.05275Inherited
Cell cycle transcription factor e2f-dp0.05795Inherited
Linker histone H1/H50.05795Inherited
Ras-binding domain, RBD0.07203Inherited
Integrin beta tail domain0.08671Inherited
Complement components0.08671Inherited
Alpha-macroglobulin receptor domain0.08671Inherited
DEP domain0.116Inherited
Fibroblast growth factors (FGF)0.1227Inherited
ZZ domain0.1265Inherited
SAM (sterile alpha motif) domain0.4539Inherited
PDZ domain0.6083Inherited
WW domain0.6325Inherited
Ankyrin repeat0.7072Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Homeodomain-like0.000000000002108Direct
p53-like transcription factors0.0000007749Direct
"Winged helix" DNA-binding domain0.000002877Direct
SMAD MH1 domain0.00003049Direct
Protein kinase-like (PK-like)0.00003901Direct
Bromodomain0.0000481Direct
Growth factor receptor domain0.0001006Direct
BRCT domain0.0001683Direct
HLH, helix-loop-helix DNA-binding domain0.0002332Direct
HMG-box0.0003504Direct
Frizzled cysteine-rich domain0.0003713Direct
SET domain0.0004784Direct
beta-beta-alpha zinc fingers0.0005614Direct
WD40 repeat-like0.0008907Direct
Nucleic acid-binding proteins0.001644Inherited
Notch domain0.002093Inherited
Cystine-knot cytokines0.003202Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.003697Inherited
Cullin repeat-like0.007645Inherited
HCP-like0.01761Inherited
Cullin homology domain0.01761Inherited
Integrin domains0.01803Inherited
SMAD/FHA domain0.01819Inherited
Nuclear receptor ligand-binding domain0.02076Inherited
Cyclin-like0.02384Inherited
DNA clamp0.02394Inherited
FYVE/PHD zinc finger0.02676Inherited
Snake toxin-like0.02696Inherited
FnI-like domain0.04442Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.04823Inherited
4-helical cytokines0.06295Inherited
Terpenoid cyclases/Protein prenyltransferases0.07739Inherited
Integrin beta tail domain0.07971Inherited
Alpha-macroglobulin receptor domain0.07971Inherited
Histone-fold0.1286Inherited
Ubiquitin-like0.2127Inherited
SAM/Pointed domain0.2326Inherited
Cytokine0.2352Inherited
GTPase activation domain, GAP0.3757Inherited
TIMP-like0.502Inherited
WW domain0.6078Inherited
Ankyrin repeat0.682Inherited
PDZ domain-like0.7405Inherited
PH domain-like0.9863Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001471Direct
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.0004069Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.002291Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.002291Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.002291Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.004435Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00554Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.006775Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.007645Inherited
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.007849Inherited
    48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0.007849Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.01761Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.01761Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.02394Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.02394Inherited
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.04823Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.04823Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.07971Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.09794Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1327Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.1748Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3408Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.3666Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.7093Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0005358Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.002093Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.002291Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.007645Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.007645Inherited
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.007849Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01761Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.07736Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.07971Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.07971Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1748Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2484Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.3095Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.7093Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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