SUPERFAMILY 1.75 HMM library and genome assignments server

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Mammalian Phenotype (MP): behavior/neurological phenotype

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   behavior/neurological phenotype [MP:0005386] <1>(38|61) (42|40|24)
- 1:   abnormal behavior [MP:0004924] <19>(37|56) (41|37|22)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SRF-like0Direct
IP3 receptor type 1 binding core, domain 20Direct
Metallothionein0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
p53 tetramerization domain0Direct
C-terminal domain of PLC-beta0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Family A G protein-coupled receptor-like0.000000008569Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000009701Direct
Nicotinic receptor ligand binding domain-like0.000009701Direct
Nuclear receptor ligand-binding domain0.00004037Direct
Periplasmic binding protein-like I0.00006521Direct
Voltage-gated potassium channels0.00009489Direct
Periplasmic binding protein-like II0.0005288Direct
PYP-like sensor domain (PAS domain)0.003123Inherited
p53-like transcription factors0.00453Inherited
Hormone receptor domain0.006907Inherited
Homeodomain-like0.007824Inherited
HLH, helix-loop-helix DNA-binding domain0.02874Inherited
ACT-like0.03329Inherited
SNF-like0.03715Inherited
STAT0.04865Inherited
Transcription factor STAT-4 N-domain0.04865Inherited
Flavoproteins0.04865Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.06042Inherited
Riboflavin synthase domain-like0.06042Inherited
Transducin (alpha subunit), insertion domain0.06133Inherited
Glycosyl hydrolase domain0.1597Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.1634Inherited
PDZ domain-like0.2207Inherited
PreATP-grasp domain0.2302Inherited
Glutathione synthetase ATP-binding domain-like0.2709Inherited
(Trans)glycosidases0.3221Inherited
Protein kinase-like (PK-like)0.3537Inherited
Second domain of FERM0.3853Inherited
Spectrin repeat0.4594Inherited
Chromo domain-like0.5894Inherited
Cadherin-like0.6766Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
MutT-like0Direct
p53 DNA-binding domain-like0Direct
Synapsin C-terminal domain0Direct
Neurotrophin0Direct
D-aminoacid oxidase-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Metallothionein0Direct
Synapsin domain0Direct
SRF-like0Direct
IP3 receptor type 1 binding core, domain 20Direct
p53 tetramerization domain0Direct
Steroid-binding domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Phenylalanine metabolism regulatory domain0Direct
C-terminal domain of PLC-beta0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Rhodopsin-like0.0000003603Direct
Nuclear receptor0.000006694Direct
Nicotinic receptor ligand binding domain-like0.000006757Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000006757Direct
Nuclear receptor ligand-binding domain0.00002907Direct
Phosphate binding protein-like0.000034Direct
L-arabinose binding protein-like0.0004892Direct
Tetramerization domain of potassium channels0.002705Inherited
Clathrin adaptor core protein0.004579Inherited
Hormone receptor domain0.005077Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.008204Inherited
YWTD domain0.008204Inherited
Homeodomain0.008566Inherited
Voltage-gated potassium channels0.01725Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.0242Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.0242Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02503Inherited
NADPH-cytochrome p450 reductase-like0.02503Inherited
HLH, helix-loop-helix DNA-binding domain0.02568Inherited
Cytoplasmic domain of inward rectifier potassium channel0.02731Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.02909Inherited
SNF-like0.02909Inherited
Laminin-type module0.03Inherited
STAT DNA-binding domain0.03778Inherited
L domain0.03778Inherited
STAT0.03778Inherited
Transcription factor STAT-4 N-domain0.03778Inherited
Laminin G-like module0.04845Inherited
Transducin (alpha subunit), insertion domain0.04978Inherited
beta-glycanases0.05409Inherited
Pyridoxal-dependent decarboxylase0.07297Inherited
ZZ domain0.08056Inherited
Acetylcholinesterase-like0.1318Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.1396Inherited
Leucine zipper domain0.1539Inherited
PDZ domain0.157Inherited
BAR domain0.2147Inherited
Spectrin repeat0.2769Inherited
Long-chain cytokines0.3248Inherited
Myb/SANT domain0.3608Inherited
Phosphotyrosine-binding domain (PTB)0.3841Inherited
Chromo domain0.4263Inherited
Protein kinases, catalytic subunit0.5055Inherited
T-box0.5347Inherited
Cadherin0.6965Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Metallothionein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
C-terminal domain of PLC-beta0Direct
p53 tetramerization domain0Direct
IP3 receptor type 1 binding core, domain 20Direct
SRF-like0Direct
Family A G protein-coupled receptor-like0.000000003241Direct
Nicotinic receptor ligand binding domain-like0.000004258Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000004258Direct
Nuclear receptor ligand-binding domain0.00001874Direct
Periplasmic binding protein-like I0.00003091Direct
Voltage-gated potassium channels0.00004565Direct
Periplasmic binding protein-like II0.0002802Direct
PYP-like sensor domain (PAS domain)0.001815Inherited
p53-like transcription factors0.002689Inherited
Hormone receptor domain0.004223Inherited
Homeodomain-like0.004806Inherited
YWTD domain0.006949Inherited
HLH, helix-loop-helix DNA-binding domain0.01945Inherited
ACT-like0.02279Inherited
SNF-like0.02564Inherited
Flavoproteins0.03427Inherited
STAT0.03427Inherited
Transcription factor STAT-4 N-domain0.03427Inherited
Riboflavin synthase domain-like0.04352Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.04352Inherited
Transducin (alpha subunit), insertion domain0.04424Inherited
Glycosyl hydrolase domain0.1273Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.1304Inherited
Leucine zipper domain0.1347Inherited
PDZ domain-like0.1824Inherited
PreATP-grasp domain0.1913Inherited
Glutathione synthetase ATP-binding domain-like0.2293Inherited
(Trans)glycosidases0.278Inherited
Protein kinase-like (PK-like)0.3082Inherited
Second domain of FERM0.3389Inherited
SH3-domain0.3647Inherited
Spectrin repeat0.4115Inherited
Chromo domain-like0.5432Inherited
Cadherin-like0.6345Inherited
GTPase activation domain, GAP0.9938Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,56496
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    103473,103473
  • 103473 - MFS general substrate transporter
  • 103473 - MFS general substrate transporter
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    57535,49854
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    56496,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.000004258Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001469Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.0008152Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.001322Inherited
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.01016Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01442Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01512Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.02151Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.02279Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.02423Inherited
    52799,52799
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.02423Inherited
    50044,48065
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.03427Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03427Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.03427Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.03427Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.03427Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03427Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07206Inherited
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0.1214Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1273Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.1273Inherited
    50729,49562
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.1275Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.494Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.7423Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    56496,49899,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49854,57535,49854
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    49785,49899,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    103473,103473,141571
  • 103473 - MFS general substrate transporter
  • 103473 - MFS general substrate transporter
  • 141571 - Pentapeptide repeat-like
  • 0Direct
    57535,49854,57535
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    49899,57196,56496
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,56496,49899
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    82109,100909,49899
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0004112Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.00358Inherited
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.01016Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.01016Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.02279Inherited
    50044,48065,50729
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.03427Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03427Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.03427Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03427Inherited
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.06714Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.2381Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.8678Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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