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Mammalian Phenotype (MP): respiratory system phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   respiratory system phenotype [MP:0005388] <2>(33|46) (36|29|15)
- 1:   abnormal respiratory system physiology [MP:0002133] <23>(15|21) (16|13|7)
- 1:   abnormal respiratory system morphology [MP:0002132] <12>(22|34) (27|22|13)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53-like transcription factors0.000005405Direct
Homeodomain-like0.00001268Direct
FnI-like domain0.00002233Direct
Protein kinase-like (PK-like)0.00005045Direct
4-helical cytokines0.0001308Direct
EGF/Laminin0.0001318Direct
Growth factor receptor domain0.001317Inherited
Notch domain0.001601Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.006689Inherited
L27 domain0.008323Inherited
Kringle-like0.009216Inherited
HLH, helix-loop-helix DNA-binding domain0.009811Inherited
Snake toxin-like0.01091Inherited
E2F-DP heterodimerization region0.01321Inherited
Flavoproteins0.01321Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.02349Inherited
Riboflavin synthase domain-like0.02349Inherited
PGBD-like0.02472Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.04668Inherited
Hemopexin-like domain0.05362Inherited
Family A G protein-coupled receptor-like0.065Inherited
TNF receptor-like0.1006Inherited
Integrin domains0.1117Inherited
DEATH domain0.1187Inherited
Nuclear receptor ligand-binding domain0.1579Inherited
Toll/Interleukin receptor TIR domain0.162Inherited
Voltage-gated potassium channels0.3485Inherited
Integrin alpha N-terminal domain0.4598Inherited
Trypsin-like serine proteases0.8437Inherited
PH domain-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
RUNT domain0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Homeodomain0.000001773Direct
Extracellular domain of cell surface receptors0.00001438Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00001438Direct
Short-chain cytokines0.00004242Direct
VWC domain0.00004242Direct
Forkhead DNA-binding domain0.00005258Direct
L domain0.00005336Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0001094Direct
Protein kinases, catalytic subunit0.00018Direct
Growth factor receptor domain0.0003852Direct
Cell cycle transcription factor e2f-dp0.0008604Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001149Inherited
Notch domain0.001149Inherited
NADPH-cytochrome p450 reductase-like0.001149Inherited
EGF-type module0.002963Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.004345Inherited
E2F dimerization segment0.004377Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.004981Inherited
Phenylalanine metabolism regulatory domain0.004981Inherited
L27 domain0.006602Inherited
HLH, helix-loop-helix DNA-binding domain0.01098Inherited
Kringle modules0.01771Inherited
Erythroid transcription factor GATA-10.01975Inherited
MMP N-terminal domain0.02143Inherited
Matrix metalloproteases, catalytic domain0.02871Inherited
Interferons/interleukin-10 (IL-10)0.03241Inherited
TNF receptor-like0.03481Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.04178Inherited
Rhodopsin-like0.04511Inherited
Hemopexin-like domain0.04813Inherited
Integrin domains0.1048Inherited
Nuclear receptor0.1279Inherited
Toll/Interleukin receptor TIR domain0.131Inherited
Nuclear receptor ligand-binding domain0.1571Inherited
DEATH domain, DD0.1615Inherited
LIM domain0.3284Inherited
Integrin alpha N-terminal domain0.3473Inherited
Eukaryotic proteases0.7881Inherited
Phosphotyrosine-binding domain (PTB)0.8394Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
p53-like transcription factors0.00000231Direct
Homeodomain-like0.000005594Direct
FnI-like domain0.00001009Direct
Protein kinase-like (PK-like)0.00002371Direct
4-helical cytokines0.00006481Direct
EGF/Laminin0.00006533Direct
Growth factor receptor domain0.0007321Direct
Notch domain0.0008989Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.004083Inherited
FAS1 domain0.004083Inherited
L27 domain0.005138Inherited
Kringle-like0.005719Inherited
HLH, helix-loop-helix DNA-binding domain0.006127Inherited
Snake toxin-like0.006858Inherited
E2F-DP heterodimerization region0.008408Inherited
Flavoproteins0.008408Inherited
Riboflavin synthase domain-like0.01561Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01561Inherited
PGBD-like0.0165Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.03285Inherited
Hemopexin-like domain0.03809Inherited
Family A G protein-coupled receptor-like0.04718Inherited
TNF receptor-like0.07594Inherited
Integrin domains0.08554Inherited
DEATH domain0.09149Inherited
Nuclear receptor ligand-binding domain0.1257Inherited
Toll/Interleukin receptor TIR domain0.1292Inherited
Cyclin-like0.1943Inherited
"Winged helix" DNA-binding domain0.2072Inherited
Voltage-gated potassium channels0.3032Inherited
Integrin alpha N-terminal domain0.412Inherited
Trypsin-like serine proteases0.8121Inherited
PH domain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000008929Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.00003706Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00003706Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.002385Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.003335Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.003479Inherited
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0.004083Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.004083Inherited
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0.004083Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.006856Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.008408Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.008408Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.008408Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.008452Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01168Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.01168Inherited
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01299Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.01613Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0165Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.02296Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02391Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02697Inherited
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.02729Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1374Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2446Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2446Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.6099Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00003706Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0004232Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.001805Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003479Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.008408Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.009045Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01299Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01613Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.02729Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.05819Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.1829Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.218Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2446Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.5797Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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