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Mammalian Phenotype (MP): skeleton phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   skeleton phenotype [MP:0005390] <2>(46|63) (50|41|26)
- 1:   abnormal skeleton morphology [MP:0005508] <15>(41|59) (47|38|25)
- 1:   abnormal skeleton physiology [MP:0001533] <12>(17|20) (18|12|6)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Homeodomain-like0Direct
BTG domain-like0Direct
p53-like transcription factors0.000002797Direct
Growth factor receptor domain0.00001021Direct
EGF/Laminin0.00006869Direct
FnI-like domain0.001359Inherited
(Trans)glycosidases0.005669Inherited
TIMP-like0.007928Inherited
HLH, helix-loop-helix DNA-binding domain0.008835Inherited
Cystine-knot cytokines0.009593Inherited
Kringle-like0.01201Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.01744Inherited
TB module/8-cys domain0.01998Inherited
Hect, E3 ligase catalytic domain0.02408Inherited
SCOP hierarchy in SUPERFAMILY0.02945Inherited
Nuclear receptor ligand-binding domain0.03408Inherited
Bromodomain0.04211Inherited
GLA-domain0.04665Inherited
Integrin beta tail domain0.04672Inherited
Leucine zipper domain0.04893Inherited
Transducin (alpha subunit), insertion domain0.05209Inherited
PGBD-like0.05471Inherited
Hemopexin-like domain0.05575Inherited
Clc chloride channel0.07922Inherited
HMG-box0.08601Inherited
TNF-like0.09102Inherited
TNF receptor-like0.09352Inherited
YWTD domain0.09414Inherited
Flavoproteins0.1563Inherited
TSP-1 type 1 repeat0.1845Inherited
Metalloproteases ("zincins"), catalytic domain0.1973Inherited
4-helical cytokines0.1978Inherited
Riboflavin synthase domain-like0.2105Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2105Inherited
Spermadhesin, CUB domain0.2218Inherited
Kazal-type serine protease inhibitors0.2454Inherited
PYP-like sensor domain (PAS domain)0.2454Inherited
Glycosyl hydrolase domain0.2766Inherited
lambda repressor-like DNA-binding domains0.3239Inherited
L domain-like0.5028Inherited
Cyclin-like0.5578Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7424Inherited
Nicotinic receptor ligand binding domain-like0.7424Inherited
Toll/Interleukin receptor TIR domain0.7661Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Homeodomain0Direct
RUNT domain0Direct
Clathrin adaptor appendage, alpha and beta chain-specific domain0Direct
BTG domain-like0Direct
Alpha-adaptin ear subdomain-like0Direct
p53 tetramerization domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Growth factor receptor domain0.0001254Direct
Paired domain0.0007214Direct
VWC domain0.0007651Direct
DIX domain0.001556Inherited
Transforming growth factor (TGF)-beta0.001911Inherited
Extracellular domain of cell surface receptors0.002231Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.002231Inherited
T-box0.00283Inherited
Notch domain0.005001Inherited
EGF-type module0.005385Inherited
Arylsulfatase0.005998Inherited
HLH, helix-loop-helix DNA-binding domain0.008337Inherited
Hect, E3 ligase catalytic domain0.01396Inherited
TB module/8-cys domain0.01529Inherited
beta-glycanases0.01544Inherited
Cytochrome p450 reductase N-terminal domain-like0.01544Inherited
I set domains0.01632Inherited
MBT repeat0.017Inherited
Nuclear receptor0.01958Inherited
TNF receptor-like0.02183Inherited
Fibroblast growth factors (FGF)0.02596Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.02863Inherited
Kringle modules0.02863Inherited
Nuclear receptor ligand-binding domain0.02971Inherited
Laminin G-like module0.03511Inherited
Bromodomain0.03566Inherited
Integrin beta tail domain0.03697Inherited
GLA-domain0.03769Inherited
Transducin (alpha subunit), insertion domain0.04275Inherited
Leucine zipper domain0.04349Inherited
NADPH-cytochrome p450 reductase-like0.04423Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.04423Inherited
Laminin-type module0.04554Inherited
MMP N-terminal domain0.04554Inherited
Hemopexin-like domain0.04689Inherited
Matrix metalloproteases, catalytic domain0.06156Inherited
Clc chloride channel0.06518Inherited
HMG-box0.07671Inherited
YWTD domain0.08001Inherited
TNF-like0.08111Inherited
Forkhead DNA-binding domain0.08111Inherited
DEATH domain, DD0.1145Inherited
Classic zinc finger, C2H20.1308Inherited
Neutral endopeptidase (neprilysin)0.1349Inherited
TSP-1 type 1 repeat0.172Inherited
Spermadhesin, CUB domain0.2089Inherited
Long-chain cytokines0.3443Inherited
Ngr ectodomain-like0.4328Inherited
EF-hand modules in multidomain proteins0.5018Inherited
SAM (sterile alpha motif) domain0.5309Inherited
Toll/Interleukin receptor TIR domain0.7178Inherited
Nicotinic receptor ligand binding domain-like0.7337Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7337Inherited
G proteins0.8734Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Homeodomain-like0Direct
p53 tetramerization domain0Direct
BTG domain-like0Direct
p53-like transcription factors0.000001177Direct
Growth factor receptor domain0.000004491Direct
EGF/Laminin0.00003266Direct
FnI-like domain0.0007566Direct
(Trans)glycosidases0.003417Inherited
Notch domain0.004295Inherited
TIMP-like0.004874Inherited
HLH, helix-loop-helix DNA-binding domain0.005465Inherited
Cystine-knot cytokines0.005976Inherited
Kringle-like0.007603Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.01137Inherited
TB module/8-cys domain0.0131Inherited
Hect, E3 ligase catalytic domain0.01603Inherited
Frizzled cysteine-rich domain0.02042Inherited
Nuclear receptor ligand-binding domain0.0234Inherited
Alkaline phosphatase-like0.02733Inherited
Bromodomain0.02936Inherited
GLA-domain0.03284Inherited
Integrin beta tail domain0.03288Inherited
Leucine zipper domain0.0345Inherited
Transducin (alpha subunit), insertion domain0.03688Inherited
PGBD-like0.03897Inherited
Hemopexin-like domain0.03978Inherited
Clc chloride channel0.05844Inherited
HMG-box0.06397Inherited
TNF-like0.06804Inherited
TNF receptor-like0.07011Inherited
YWTD domain0.07058Inherited
Flavoproteins0.1243Inherited
TSP-1 type 1 repeat0.1493Inherited
Metalloproteases ("zincins"), catalytic domain0.1608Inherited
4-helical cytokines0.1612Inherited
Riboflavin synthase domain-like0.1729Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1729Inherited
Spermadhesin, CUB domain0.1835Inherited
Kazal-type serine protease inhibitors0.2055Inherited
PYP-like sensor domain (PAS domain)0.2055Inherited
beta-beta-alpha zinc fingers0.2089Inherited
LDL receptor-like module0.2159Inherited
Glycosyl hydrolase domain0.2347Inherited
lambda repressor-like DNA-binding domains0.2796Inherited
L domain-like0.4551Inherited
Cyclin-like0.5112Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7039Inherited
Nicotinic receptor ligand binding domain-like0.7039Inherited
Toll/Interleukin receptor TIR domain0.7286Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    49265,53300
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.000067Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0013Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.001688Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001717Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.001818Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.004295Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.005267Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.009217Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01012Inherited
    53300,49265
  • 53300 - vWA-like
  • 49265 - Fibronectin type III
  • 0.01362Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.01362Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.01483Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.01483Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.01483Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.0259Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0259Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.03284Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.03288Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.03288Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.03897Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.03991Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.05844Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.07058Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07058Inherited
    48726,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 0.07756Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1006Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.1241Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.1241Inherited
    63748,63748
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 0.1298Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1558Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.1774Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2233Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.2347Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.2659Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2949Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.7039Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49265,49265,53300
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0006318Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0013Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.003564Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003564Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.004295Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.004295Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.005267Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0131Inherited
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.01362Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.01483Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.01483Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.02459Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.03288Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03787Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.03967Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.03991Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.03991Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05844Inherited
    48726,56436,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.07756Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.09564Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.09564Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.8428Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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