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Mammalian Phenotype (MP): skeleton phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   skeleton phenotype [MP:0005390] <2>(46|63) (50|41|26)
- 1:   abnormal skeleton morphology [MP:0005508] <15>(41|59) (47|38|25)
- 1:   abnormal skeleton physiology [MP:0001533] <12>(17|20) (18|12|6)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Homeodomain-like0Direct
BTG domain-like0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53-like transcription factors0.000002776Direct
Growth factor receptor domain0.00001009Direct
EGF/Laminin0.00006783Direct
FnI-like domain0.001353Inherited
(Trans)glycosidases0.005647Inherited
TIMP-like0.007905Inherited
HLH, helix-loop-helix DNA-binding domain0.008777Inherited
Cystine-knot cytokines0.009537Inherited
Kringle-like0.01197Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.01737Inherited
TB module/8-cys domain0.01994Inherited
Hect, E3 ligase catalytic domain0.02399Inherited
SCOP hierarchy in SUPERFAMILY0.02941Inherited
Nuclear receptor ligand-binding domain0.03394Inherited
Bromodomain0.04198Inherited
GLA-domain0.04654Inherited
Integrin beta tail domain0.04662Inherited
Leucine zipper domain0.04879Inherited
Transducin (alpha subunit), insertion domain0.05197Inherited
PGBD-like0.05461Inherited
Hemopexin-like domain0.05561Inherited
Clc chloride channel0.0791Inherited
HMG-box0.08588Inherited
TNF-like0.09077Inherited
TNF receptor-like0.09332Inherited
YWTD domain0.09396Inherited
Flavoproteins0.1561Inherited
TSP-1 type 1 repeat0.184Inherited
Metalloproteases ("zincins"), catalytic domain0.1966Inherited
4-helical cytokines0.1974Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2103Inherited
Riboflavin synthase domain-like0.2103Inherited
Spermadhesin, CUB domain0.2214Inherited
Kazal-type serine protease inhibitors0.2449Inherited
PYP-like sensor domain (PAS domain)0.2449Inherited
Glycosyl hydrolase domain0.2763Inherited
lambda repressor-like DNA-binding domains0.3234Inherited
L domain-like0.5017Inherited
Cyclin-like0.5574Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7418Inherited
Nicotinic receptor ligand binding domain-like0.7418Inherited
Toll/Interleukin receptor TIR domain0.7658Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
RUNT domain0Direct
Homeodomain0Direct
Clathrin adaptor appendage, alpha and beta chain-specific domain0Direct
BTG domain-like0Direct
Alpha-adaptin ear subdomain-like0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Growth factor receptor domain0.0001244Direct
Paired domain0.0007192Direct
VWC domain0.0007619Direct
DIX domain0.00155Inherited
Transforming growth factor (TGF)-beta0.001899Inherited
Extracellular domain of cell surface receptors0.002223Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.002223Inherited
T-box0.002817Inherited
Notch domain0.004988Inherited
EGF-type module0.005346Inherited
Arylsulfatase0.005979Inherited
HLH, helix-loop-helix DNA-binding domain0.008267Inherited
Hect, E3 ligase catalytic domain0.01389Inherited
TB module/8-cys domain0.01525Inherited
beta-glycanases0.01542Inherited
Cytochrome p450 reductase N-terminal domain-like0.01542Inherited
MBT repeat0.01696Inherited
Nuclear receptor0.01949Inherited
TNF receptor-like0.02175Inherited
I set domains0.02288Inherited
Fibroblast growth factors (FGF)0.02589Inherited
Kringle modules0.02856Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.02856Inherited
Nuclear receptor ligand-binding domain0.02958Inherited
Laminin G-like module0.03497Inherited
Bromodomain0.03552Inherited
Integrin beta tail domain0.0369Inherited
GLA-domain0.0376Inherited
Transducin (alpha subunit), insertion domain0.04263Inherited
Leucine zipper domain0.04332Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.04415Inherited
NADPH-cytochrome p450 reductase-like0.04415Inherited
MMP N-terminal domain0.04542Inherited
Laminin-type module0.04542Inherited
Hemopexin-like domain0.04677Inherited
Matrix metalloproteases, catalytic domain0.0614Inherited
Clc chloride channel0.06505Inherited
HMG-box0.07648Inherited
YWTD domain0.07983Inherited
TNF-like0.08084Inherited
Forkhead DNA-binding domain0.08084Inherited
DEATH domain, DD0.1142Inherited
Classic zinc finger, C2H20.1301Inherited
Neutral endopeptidase (neprilysin)0.1347Inherited
TSP-1 type 1 repeat0.1717Inherited
Spermadhesin, CUB domain0.2084Inherited
Long-chain cytokines0.3439Inherited
Ngr ectodomain-like0.432Inherited
EF-hand modules in multidomain proteins0.5014Inherited
SAM (sterile alpha motif) domain0.5304Inherited
Toll/Interleukin receptor TIR domain0.7173Inherited
Nicotinic receptor ligand binding domain-like0.7332Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7332Inherited
G proteins0.8727Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Homeodomain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
BTG domain-like0Direct
p53-like transcription factors0.000001166Direct
Growth factor receptor domain0.000004431Direct
EGF/Laminin0.0000322Direct
FnI-like domain0.0007529Direct
(Trans)glycosidases0.003402Inherited
Notch domain0.004286Inherited
TIMP-like0.004858Inherited
HLH, helix-loop-helix DNA-binding domain0.005426Inherited
Cystine-knot cytokines0.00594Inherited
Kringle-like0.007576Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.0113Inherited
TB module/8-cys domain0.01308Inherited
Hect, E3 ligase catalytic domain0.01597Inherited
Frizzled cysteine-rich domain0.02036Inherited
Nuclear receptor ligand-binding domain0.02329Inherited
Alkaline phosphatase-like0.02728Inherited
Bromodomain0.02926Inherited
GLA-domain0.03275Inherited
Integrin beta tail domain0.03281Inherited
Leucine zipper domain0.03439Inherited
Transducin (alpha subunit), insertion domain0.03679Inherited
PGBD-like0.03888Inherited
Hemopexin-like domain0.03967Inherited
Clc chloride channel0.05833Inherited
HMG-box0.06382Inherited
TNF-like0.06783Inherited
TNF receptor-like0.06994Inherited
YWTD domain0.07046Inherited
Flavoproteins0.1241Inherited
TSP-1 type 1 repeat0.1489Inherited
Metalloproteases ("zincins"), catalytic domain0.1602Inherited
4-helical cytokines0.1609Inherited
Riboflavin synthase domain-like0.1727Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1727Inherited
Spermadhesin, CUB domain0.1831Inherited
PYP-like sensor domain (PAS domain)0.2051Inherited
Kazal-type serine protease inhibitors0.2051Inherited
beta-beta-alpha zinc fingers0.2079Inherited
LDL receptor-like module0.2155Inherited
Glycosyl hydrolase domain0.2345Inherited
lambda repressor-like DNA-binding domains0.2791Inherited
L domain-like0.4541Inherited
Cyclin-like0.5107Inherited
Nicotinic receptor ligand binding domain-like0.7032Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7032Inherited
Toll/Interleukin receptor TIR domain0.7283Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49265,53300
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00006671Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.001296Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00168Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00171Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.001812Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.004286Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.005257Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.009175Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01006Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.0136Inherited
    53300,49265
  • 53300 - vWA-like
  • 49265 - Fibronectin type III
  • 0.0136Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0148Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.0148Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0148Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02585Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.02585Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.03275Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.03281Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.03281Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.03888Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.03986Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.05833Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07046Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.07046Inherited
    48726,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 0.07744Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.1238Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.1238Inherited
    63748,63748
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 0.1296Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1556Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.1772Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2229Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.2345Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.2654Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2945Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.7032Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49265,49265,53300
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0006298Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.001296Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.003552Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003552Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.004286Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.004286Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.005257Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01308Inherited
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.0136Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.0148Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.0148Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.02444Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.03281Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03777Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.03956Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.03986Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.03986Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05833Inherited
    48726,56436,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.07744Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.09545Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.09545Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.8422Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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