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Mammalian Phenotype (MP): vision/eye phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   vision/eye phenotype [MP:0005391] <2>(43|53) (50|27|17)
- 1:   abnormal eye physiology [MP:0005253] <25>(8|9) (9|5|2)
- 1:   abnormal eye morphology [MP:0002092] <23>(39|49) (46|25|15)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Di-copper centre-containing domain0Direct
Tubby C-terminal domain-like0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Notch domain0Direct
gamma-Crystallin-like0.000001657Direct
EGF/Laminin0.00003184Direct
FnI-like domain0.0002628Direct
Plexin repeat0.0005131Direct
Cystine-knot cytokines0.001079Inherited
Homeodomain-like0.001104Inherited
HLH, helix-loop-helix DNA-binding domain0.003766Inherited
CalX-like0.005545Inherited
Sema domain0.01036Inherited
Nuclear receptor ligand-binding domain0.02257Inherited
GroEL equatorial domain-like0.02424Inherited
GAF domain-like0.04752Inherited
TNF-like0.0576Inherited
Transducin (heterotrimeric G protein), gamma chain0.07054Inherited
E2F-DP heterodimerization region0.07689Inherited
Cupredoxins0.08177Inherited
PGBD-like0.08642Inherited
HMG-box0.08966Inherited
Clc chloride channel0.1109Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1236Inherited
Integrin domains0.1434Inherited
CBS-domain pair0.1554Inherited
Cyclin-like0.1651Inherited
Kringle-like0.174Inherited
"Winged helix" DNA-binding domain0.1937Inherited
Tetraspanin0.2229Inherited
Metalloproteases ("zincins"), catalytic domain0.3454Inherited
Regulator of G-protein signaling, RGS0.3699Inherited
Blood coagulation inhibitor (disintegrin)0.37Inherited
HD-domain/PDEase-like0.37Inherited
Transducin (alpha subunit), insertion domain0.4066Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4212Inherited
Nicotinic receptor ligand binding domain-like0.4212Inherited
Toll/Interleukin receptor TIR domain0.5157Inherited
L domain-like0.5357Inherited
NAD(P)-binding Rossmann-fold domains0.5375Inherited
DBL homology domain (DH-domain)0.7949Inherited
Trypsin-like serine proteases0.9865Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Transcriptional factor tubby, C-terminal domain0Direct
Notch domain0Direct
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Crystallins/Ca-binding development proteins0.000001045Direct
VWC domain0.00006585Direct
Arylsulfatase0.0000935Direct
Forkhead DNA-binding domain0.0001035Direct
Plexin repeat0.0003869Direct
Homeodomain0.0005287Direct
EGF-type module0.0005358Direct
I set domains0.001696Inherited
HLH, helix-loop-helix DNA-binding domain0.003383Inherited
CalX-beta domain0.003969Inherited
Noncollagenous (NC1) domain of collagen IV0.005349Inherited
YWTD domain0.005812Inherited
Sema domain0.008221Inherited
Laminin-type module0.008727Inherited
Transforming growth factor (TGF)-beta0.01246Inherited
Nuclear receptor0.01304Inherited
Extracellular domain of cell surface receptors0.0149Inherited
Nuclear receptor ligand-binding domain0.01913Inherited
GAF domain0.03716Inherited
E2F dimerization segment0.03716Inherited
TNF-like0.04949Inherited
MMP N-terminal domain0.07305Inherited
HMG-box0.07886Inherited
Matrix metalloproteases, catalytic domain0.09105Inherited
Clc chloride channel0.09338Inherited
Tyrosine-dependent oxidoreductases0.09561Inherited
CBS-domain pair0.1068Inherited
TNF receptor-like0.1111Inherited
Integrin domains0.1273Inherited
Cell cycle transcription factor e2f-dp0.128Inherited
Transducin (heterotrimeric G protein), gamma chain0.128Inherited
Kringle modules0.1672Inherited
Calmodulin-like0.1928Inherited
PDZ domain0.2341Inherited
POU-specific domain0.2721Inherited
PDEase0.2721Inherited
Ngr ectodomain-like0.2876Inherited
Blood coagulation inhibitor (disintegrin)0.3479Inherited
Regulator of G-protein signaling, RGS0.3513Inherited
Transducin (alpha subunit), insertion domain0.3818Inherited
Nicotinic receptor ligand binding domain-like0.4055Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4055Inherited
cAMP-binding domain0.4177Inherited
Cyclin0.5477Inherited
DBL homology domain (DH-domain)0.7863Inherited
Eukaryotic proteases0.9917Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Di-copper centre-containing domain0Direct
Tubby C-terminal domain-like0Direct
p53 tetramerization domain0Direct
Notch domain0Direct
gamma-Crystallin-like0.0000006804Direct
EGF/Laminin0.00001463Direct
FnI-like domain0.0001345Direct
Plexin repeat0.0002719Direct
Cystine-knot cytokines0.0005921Direct
Homeodomain-like0.0006065Direct
Alkaline phosphatase-like0.001031Inherited
Growth factor receptor domain0.001081Inherited
Integrin beta tail domain0.001217Inherited
HLH, helix-loop-helix DNA-binding domain0.002209Inherited
CalX-like0.003336Inherited
YWTD domain0.004766Inherited
Sema domain0.006486Inherited
Nuclear receptor ligand-binding domain0.01494Inherited
GroEL equatorial domain-like0.01615Inherited
GAF domain-like0.03346Inherited
TNF-like0.04126Inherited
Transducin (heterotrimeric G protein), gamma chain0.05159Inherited
E2F-DP heterodimerization region0.0566Inherited
Cupredoxins0.06049Inherited
PGBD-like0.0643Inherited
HMG-box0.06689Inherited
Clc chloride channel0.08486Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.09559Inherited
Integrin domains0.1129Inherited
beta-sandwich domain of Sec23/240.1176Inherited
CBS-domain pair0.1235Inherited
Cyclin-like0.1319Inherited
Kringle-like0.1398Inherited
"Winged helix" DNA-binding domain0.1575Inherited
Tetraspanin0.1845Inherited
TNF receptor-like0.2023Inherited
Metalloproteases ("zincins"), catalytic domain0.3Inherited
Regulator of G-protein signaling, RGS0.324Inherited
Blood coagulation inhibitor (disintegrin)0.3241Inherited
HD-domain/PDEase-like0.3241Inherited
Transducin (alpha subunit), insertion domain0.3597Inherited
Nicotinic receptor ligand binding domain-like0.3743Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3743Inherited
Toll/Interleukin receptor TIR domain0.4682Inherited
L domain-like0.4886Inherited
NAD(P)-binding Rossmann-fold domains0.4904Inherited
Intermediate filament protein, coiled coil region0.7485Inherited
DBL homology domain (DH-domain)0.7598Inherited
Trypsin-like serine proteases0.9708Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000003656Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.001217Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00282Inherited
    48670,48097
  • 48670 - Transducin (heterotrimeric G protein), gamma chain
  • 48097 - Regulator of G-protein signaling, RGS
  • 0.00514Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.005424Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.006486Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.007135Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.01094Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.01094Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.02082Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03346Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.03346Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0566Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0643Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.08486Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.107Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.2179Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.262Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3173Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.3241Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.3601Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.3743Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.7203Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49265,48726,49265
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0Direct
    101288,50156,50044
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00001539Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.001217Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.004577Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.005524Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.007727Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.01261Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01615Inherited
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01615Inherited
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02082Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03346Inherited
    50156,50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.0566Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.07234Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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