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Mammalian Phenotype (MP): abnormal circulating protein level

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + 2:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ 1:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
+ 1:   abnormal protein level [MP:0008469] <15>(23|31) (25|13|3)
0:   abnormal circulating protein level [MP:0005416] <24>(18|25) (20|10|3)
- 1:   abnormal circulating enzyme level [MP:0001570] <15>(7|8) (10|3|0)
- 1:   abnormal circulating cytokine level [MP:0010210] <4>(10|17) (10|6|2)
- 1:   abnormal circulating transferrin level [MP:0011892] <3>(0|0) (0|0|0)
- 1:   abnormal circulating angiotensinogen level [MP:0006373] <2>(0|0) (0|0|0)
- 1:   abnormal circulating antithrombin level [MP:0012324] <2>(0|0) (0|0|0)
- 1:   abnormal circulating complement protein level [MP:0010215] <2>(0|0) (0|0|0)
- 1:   abnormal circulating factor VIII level [MP:0012327] <2>(0|0) (0|0|0)
- 1:   abnormal circulating ferritin level [MP:0011889] <2>(0|0) (0|0|0)
- 1:   abnormal circulating fibrinogen level [MP:0010213] <2>(0|0) (0|0|0)
- 1:   abnormal circulating fibronectin level [MP:0011912] <2>(0|0) (0|0|0)
- 1:   abnormal circulating prothrombin level [MP:0012221] <2>(0|0) (0|0|0)
- 1:   abnormal circulating serum albumin level [MP:0000199] <2>(0|0) (0|0|0)
- 1:   abnormal circulating thrombin level [MP:0013255] <2>(0|0) (0|0|0)
- 1:   abnormal circulating total protein level [MP:0011888] <2>(0|1) (0|0|0)
- 1:   abnormal glycosylated hemoglobin level [MP:0006351] <2>(0|0) (0|0|0)
- 1:   abnormal circulating apolipoprotein level [MP:0010332] <1>(0|0) (0|0|0)
- 1:   abnormal circulating C-reactive protein level [MP:0010212](0|0) (0|0|0)
- 1:   abnormal circulating retinol binding protein level [MP:0010216](0|0) (0|0|0)
- 1:   abnormal circulating serum amyloid protein level [MP:0010214](0|0) (0|0|0)
- 1:   decreased circulating ceruloplasmin level [MP:0012661](0|0) (0|0|0)
- 1:   decreased circulating haptoglobin level [MP:0012664](0|0) (0|0|0)
- 1:   hemoglobinemia [MP:0000332](0|0) (0|0|0)
- 1:   increased circulating ceruloplasmin level [MP:0012662](0|0) (0|0|0)
- 1:   increased circulating haptoglobin level [MP:0012666](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.000001199Direct
STAT0.000008022Direct
Transcription factor STAT-4 N-domain0.000008022Direct
Toll/Interleukin receptor TIR domain0.00002308Direct
C-type lectin-like0.00006631Direct
FAS1 domain0.002178Inherited
Fibronectin type III0.005455Inherited
4-helical cytokines0.008178Inherited
SH2 domain0.02225Inherited
Caspase-like0.03655Inherited
Flavoproteins0.07405Inherited
p53-like transcription factors0.09747Inherited
CCCH zinc finger0.1155Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1378Inherited
Riboflavin synthase domain-like0.1378Inherited
E set domains0.2725Inherited
CAD & PB1 domains0.329Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
STAT DNA-binding domain0.000005082Direct
STAT0.000005082Direct
Transcription factor STAT-4 N-domain0.000005082Direct
Toll/Interleukin receptor TIR domain0.00003577Direct
Interleukin-1 (IL-1)0.0002407Direct
DEATH domain, DD0.0002812Direct
FAS1 domain0.001489Inherited
Notch domain0.005037Inherited
Fibronectin type III0.005563Inherited
28-residue LRR0.006629Inherited
Interferon regulatory factor0.008521Inherited
Interferons/interleukin-10 (IL-10)0.009073Inherited
SH2 domain0.01753Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01969Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.01969Inherited
NADPH-cytochrome p450 reductase-like0.01969Inherited
Pyrin domain, PYD0.01969Inherited
Caspase catalytic domain0.02108Inherited
p120GAP domain-like0.06083Inherited
Long-chain cytokines0.06306Inherited
Caspase recruitment domain, CARD0.07821Inherited
CCCH zinc finger0.09975Inherited
Growth factor receptor domain0.2361Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.0000004904Direct
STAT0.000003487Direct
Transcription factor STAT-4 N-domain0.000003487Direct
Toll/Interleukin receptor TIR domain0.00001045Direct
C-type lectin-like0.00003145Direct
FAS1 domain0.001242Inherited
Fibronectin type III0.003278Inherited
Notch domain0.004264Inherited
4-helical cytokines0.005044Inherited
SH2 domain0.01472Inherited
Caspase-like0.02516Inherited
Glycosyl hydrolase domain0.05438Inherited
Flavoproteins0.05438Inherited
p53-like transcription factors0.07341Inherited
CCCH zinc finger0.08878Inherited
Riboflavin synthase domain-like0.1081Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1081Inherited
E set domains0.2308Inherited
CAD & PB1 domains0.2844Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.000003487Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.000003487Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.000003487Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0002251Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.000807Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0.001242Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04164Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.05438Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1418Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.000003487Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.000003487Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)