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Mammalian Phenotype (MP): abnormal circulating hormone level

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + 2:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ 1:   abnormal hormone level [MP:0003953] <15>(27|29) (30|17|8)
+ 1:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
0:   abnormal circulating hormone level [MP:0005418] <26>(24|23) (25|13|4)
- 1:   abnormal circulating glucocorticoid level [MP:0003366] <4>(1|1) (1|0|0)
- 1:   abnormal circulating adrenaline level [MP:0005660] <3>(0|0) (0|0|0)
- 1:   abnormal circulating estrogen level [MP:0003369] <3>(2|1) (2|1|0)
- 1:   abnormal circulating mineralocorticoid level [MP:0003372] <3>(1|1) (1|0|0)
- 1:   abnormal circulating noradrenaline level [MP:0005663] <3>(2|2) (2|1|0)
- 1:   abnormal circulating androgen level [MP:0009819] <2>(2|2) (2|1|0)
- 1:   abnormal circulating antidiuretic hormone level [MP:0005609] <2>(0|0) (0|0|0)
- 1:   abnormal circulating atrial natriuretic factor level [MP:0005521] <2>(0|0) (0|0|0)
- 1:   abnormal circulating erythropoietin level [MP:0011284] <2>(0|0) (0|0|0)
- 1:   abnormal circulating gastrin level [MP:0004730] <2>(0|0) (0|0|0)
- 1:   abnormal circulating ghrelin level [MP:0011611] <2>(0|0) (0|0|0)
- 1:   abnormal circulating glucagon level [MP:0002695] <2>(0|0) (0|0|0)
- 1:   abnormal circulating gonadotropin level [MP:0003361] <2>(4|6) (4|1|0)
- 1:   abnormal circulating insulin level [MP:0001560] <2>(4|6) (5|8|3)
- 1:   abnormal circulating insulin-like growth factor I level [MP:0004700] <2>(5|6) (5|5|2)
- 1:   abnormal circulating leptin level [MP:0005667] <2>(8|7) (8|6|3)
- 1:   abnormal circulating parathyroid hormone level [MP:0002903] <2>(1|1) (1|1|0)
- 1:   abnormal circulating pituitary hormone level [MP:0005116] <2>(6|5) (6|1|0)
- 1:   abnormal circulating progesterone level [MP:0005184] <2>(1|2) (1|0|0)
- 1:   abnormal circulating thyroxine level [MP:0005475] <2>(1|0) (1|0|0)
- 1:   abnormal circulating triiodothyronine level [MP:0005476] <2>(0|0) (0|0|0)
- 1:   decreased circulating levels of thyroid hormone [MP:0003351] <2>(0|0) (0|0|0)
- 1:   increased circulating levels of thyroid hormone [MP:0003350] <2>(1|0) (1|0|0)
- 1:   abnormal circulating osteocalcin level [MP:0011922](0|0) (0|0|0)
- 1:   abnormal circulating pancreatic peptide level [MP:0008459](0|0) (0|0|0)
- 1:   increased circulating corticotropin-releasing hormone level [MP:0001754](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Family A G protein-coupled receptor-like0.000000008615Direct
Nuclear receptor ligand-binding domain0.000006871Direct
KA1-like0.00003316Direct
Hormone receptor domain0.0003687Direct
PYP-like sensor domain (PAS domain)0.001747Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.003065Inherited
Riboflavin synthase domain-like0.003065Inherited
Heme-dependent peroxidases0.004791Inherited
GroEL equatorial domain-like0.005118Inherited
SMAD MH1 domain0.007669Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.01039Inherited
ClpP/crotonase0.04392Inherited
Nuclear receptor coactivator interlocking domain0.04392Inherited
Thyroglobulin type-1 domain0.05623Inherited
HLH, helix-loop-helix DNA-binding domain0.06715Inherited
Cytochrome P4500.0838Inherited
Cystine-knot cytokines0.0849Inherited
CAD & PB1 domains0.1039Inherited
Transducin (alpha subunit), insertion domain0.1642Inherited
STAT0.1865Inherited
Transcription factor STAT-4 N-domain0.1865Inherited
Thioredoxin-like0.2788Inherited
p53-like transcription factors0.2796Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Rhodopsin-like0.0000002789Direct
Nuclear receptor ligand-binding domain0.000004474Direct
Nuclear receptor0.00001071Direct
Hormone receptor domain0.0002362Direct
Kinase associated domain 1, KA10.001061Inherited
Myeloperoxidase-like0.003533Inherited
SMAD MH1 domain0.005361Inherited
SMAD domain0.005361Inherited
Phosphotyrosine-binding domain (PTB)0.00871Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.01002Inherited
Forkhead DNA-binding domain0.01298Inherited
Nuclear receptor coactivator interlocking domain0.03329Inherited
Thyroglobulin type-1 domain0.04715Inherited
HLH, helix-loop-helix DNA-binding domain0.06553Inherited
Cytochrome P4500.06941Inherited
Transforming growth factor (TGF)-beta0.0922Inherited
Transducin (alpha subunit), insertion domain0.1402Inherited
STAT DNA-binding domain0.1604Inherited
STAT0.1604Inherited
Transcription factor STAT-4 N-domain0.1604Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.2408Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Family A G protein-coupled receptor-like0.00000000326Direct
Nuclear receptor ligand-binding domain0.00000296Direct
KA1-like0.00001526Direct
Hormone receptor domain0.0001922Direct
PYP-like sensor domain (PAS domain)0.0009874Direct
Riboflavin synthase domain-like0.00178Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.00178Inherited
Heme-dependent peroxidases0.00286Inherited
GroEL equatorial domain-like0.003067Inherited
SMAD MH1 domain0.00471Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.006506Inherited
ClpP/crotonase0.03068Inherited
Nuclear receptor coactivator interlocking domain0.03068Inherited
t-snare proteins0.03844Inherited
Thyroglobulin type-1 domain0.04017Inherited
HLH, helix-loop-helix DNA-binding domain0.04887Inherited
Cytochrome P4500.06213Inherited
Cystine-knot cytokines0.06304Inherited
CAD & PB1 domains0.07875Inherited
Transducin (alpha subunit), insertion domain0.1311Inherited
STAT0.151Inherited
Transcription factor STAT-4 N-domain0.151Inherited
Thioredoxin-like0.2369Inherited
p53-like transcription factors0.2375Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001561Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.0001922Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0005831Direct
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.004286Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.006896Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.02013Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.03068Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1311Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.151Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.151Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.151Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.2289Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.3114Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0002488Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.151Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.151Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.2289Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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