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Mammalian Phenotype (MP): abnormal leukopoiesis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ + + + 4:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
+ + + 3:   abnormal blood cell morphology/development [MP:0002429] <3>(26|35) (28|24|9)
+ + + 3:   abnormal blood cell morphology [MP:0013657] <4>(31|49) (37|35|14)
+ + + 3:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + 2:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + 2:   abnormal hemopoiesis [MP:0013693] <2>(25|34) (27|24|9)
+ 1:   abnormal definitive hematopoiesis [MP:0002123] <4>(24|34) (26|24|9)
+ 1:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)
0:   abnormal leukopoiesis [MP:0005460] <3>(17|28) (21|18|8)
- 1:   abnormal myelopoiesis [MP:0001601] <8>(0|0) (0|0|0)
- 1:   abnormal lymphopoiesis [MP:0002401] <3>(17|25) (21|15|6)
- 1:   abnormal mononuclear cell differentiation [MP:0002445] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
SH2 domain0.00000000004959Direct
p53-like transcription factors0.000001001Direct
DNA polymerase beta, N-terminal domain-like0.0001486Direct
Bcl-2 inhibitors of programmed cell death0.0006375Direct
E2F-DP heterodimerization region0.001561Inherited
BRCT domain0.005145Inherited
SMAD/FHA domain0.01429Inherited
DNA/RNA polymerases0.0183Inherited
Nucleotidyltransferase0.032Inherited
Cysteine-rich domain0.03643Inherited
SH3-domain0.08752Inherited
TNF receptor-like0.08755Inherited
SET domain0.1298Inherited
DBL homology domain (DH-domain)0.5319Inherited
Calponin-homology domain, CH-domain0.775Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA polymerase beta-like, second domain0Direct
DNA polymerase beta-like0Direct
SH2 domain0.00000000003855Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000001046Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0000006541Direct
PLC-like (P variant)0.0000872Direct
DNA polymerase beta, N-terminal domain-like0.00009284Direct
E2F dimerization segment0.0004014Direct
Bcl-2 inhibitors of programmed cell death0.000424Direct
ets domain0.001758Inherited
Cell cycle transcription factor e2f-dp0.004023Inherited
DNA polymerase I0.005691Inherited
STAT DNA-binding domain0.007438Inherited
STAT0.007438Inherited
Transcription factor STAT-4 N-domain0.007438Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.01047Inherited
Pointed domain0.03216Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.03528Inherited
Pleckstrin-homology domain (PH domain)0.03956Inherited
DEATH domain, DD0.04356Inherited
Myb/SANT domain0.05004Inherited
MATH domain0.0658Inherited
SH3-domain0.07576Inherited
FHA domain0.09506Inherited
TNF receptor-like0.1103Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1641Inherited
DBL homology domain (DH-domain)0.505Inherited
Calponin-homology domain, CH-domain0.7531Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
SH2 domain0.00000000001805Direct
p53-like transcription factors0.0000004071Direct
DNA polymerase beta, N-terminal domain-like0.00007409Direct
Bcl-2 inhibitors of programmed cell death0.0003401Direct
E2F-DP heterodimerization region0.000875Direct
BRCT domain0.003084Inherited
STAT0.006566Inherited
Transcription factor STAT-4 N-domain0.006566Inherited
SMAD/FHA domain0.009162Inherited
DNA/RNA polymerases0.01192Inherited
Nucleotidyltransferase0.02187Inherited
Cysteine-rich domain0.02508Inherited
beta-beta-alpha zinc fingers0.05545Inherited
SH3-domain0.06519Inherited
TNF receptor-like0.06521Inherited
SET domain0.101Inherited
Acyl-CoA N-acyltransferases (Nat)0.2831Inherited
DBL homology domain (DH-domain)0.4848Inherited
Calponin-homology domain, CH-domain0.7383Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00000006542Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.000005407Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.000008188Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0004766Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.000602Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.000875Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.00286Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.006566Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.006566Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.006566Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.01399Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.01454Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.0228Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.4848Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.000602Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.006566Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.006566Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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