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Mammalian Phenotype (MP): abnormal circulating leptin level

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + + 3:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ + 2:   abnormal hormone level [MP:0003953] <15>(27|29) (30|17|8)
+ + 2:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
+ 1:   abnormal circulating hormone level [MP:0005418] <26>(24|23) (25|13|4)
0:   abnormal circulating leptin level [MP:0005667] <2>(8|7) (8|6|3)
- 1:   decreased circulating leptin level [MP:0005668](0|0) (0|0|0)
- 1:   increased circulating leptin level [MP:0005669](6|6) (6|6|3)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
GroEL equatorial domain-like0.00006701Direct
Nuclear receptor coactivator interlocking domain0.00006701Direct
STAT0.000329Direct
Transcription factor STAT-4 N-domain0.000329Direct
CAD & PB1 domains0.0005439Direct
PYP-like sensor domain (PAS domain)0.1031Inherited
Nuclear receptor ligand-binding domain0.626Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Nuclear receptor coactivator interlocking domain0.00004043Direct
STAT DNA-binding domain0.0002106Direct
STAT0.0002106Direct
Transcription factor STAT-4 N-domain0.0002106Direct
Nuclear receptor0.5413Inherited
Nuclear receptor ligand-binding domain0.5889Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
GroEL equatorial domain-like0.00003184Direct
Nuclear receptor coactivator interlocking domain0.00003184Direct
STAT0.0001704Direct
Transcription factor STAT-4 N-domain0.0001704Direct
CAD & PB1 domains0.0002886Direct
PYP-like sensor domain (PAS domain)0.07804Inherited
Nuclear receptor ligand-binding domain0.5813Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001704Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0001704Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001704Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.05457Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1265Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.1809Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001704Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001704Direct
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.05457Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)