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Mammalian Phenotype (MP): increased apoptosis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   cellular phenotype [MP:0005384] <6>(95|116) (103|56|31)
+ + + 3:   abnormal cell physiology [MP:0005621] <24>(77|96) (84|46|25)
+ + 2:   abnormal cell death [MP:0000313] <5>(29|41) (33|15|5)
+ 1:   increased cell death [MP:0012556] <1>(16|23) (18|7|3)
+ 1:   abnormal apoptosis [MP:0001648] <30>(27|38) (30|13|5)
0:   increased apoptosis [MP:0006042] <34>(16|23) (18|7|3)
- 1:   increased embryonic tissue cell apoptosis [MP:0013504] <6>(0|1) (0|0|0)
- 1:   increased kidney apoptosis [MP:0011368] <4>(4|4) (4|0|0)
- 1:   increased T cell apoptosis [MP:0006413] <3>(0|0) (0|0|0)
- 1:   increased brain apoptosis [MP:0014178] <3>(0|0) (0|0|0)
- 1:   increased lung apoptosis [MP:0030002] <1>(0|0) (0|0|0)
- 1:   increased neuron apoptosis [MP:0003203] <1>(0|1) (0|0|0)
- 1:   increased B cell apoptosis [MP:0008782](1|2) (1|0|0)
- 1:   increased activation-induced B cell apoptosis [MP:0010674](0|0) (0|0|0)
- 1:   increased activation-induced cell death of T cells [MP:0010676](0|0) (0|0|0)
- 1:   increased allantois apoptosis [MP:0003891](0|0) (0|0|0)
- 1:   increased anoikis [MP:0011810](0|0) (0|0|0)
- 1:   increased cardiomyocyte apoptosis [MP:0003222](0|1) (1|0|0)
- 1:   increased chondrocyte apoptosis [MP:0014103](0|0) (0|0|0)
- 1:   increased enterocyte apoptosis [MP:0008885](1|1) (1|0|0)
- 1:   increased fetal cardiomyocyte apoptosis [MP:0011392](0|0) (0|0|0)
- 1:   increased fibroblast apoptosis [MP:0013501](1|1) (1|0|0)
- 1:   increased granulosa cell apoptosis [MP:0013508](1|2) (2|1|0)
- 1:   increased hair follicle apoptosis [MP:0011195](0|0) (0|0|0)
- 1:   increased hepatocyte apoptosis [MP:0003887](1|1) (1|0|0)
- 1:   increased keratinocyte apoptosis [MP:0009580](0|0) (0|0|0)
- 1:   increased lacrimal gland apoptosis [MP:0013452](0|0) (0|0|0)
- 1:   increased lens epithelium apoptosis [MP:0008794](0|0) (0|0|0)
- 1:   increased lens fiber apoptosis [MP:0008796](0|0) (0|0|0)
- 1:   increased lung endothelial cell apoptosis [MP:0011141](0|0) (0|0|0)
- 1:   increased macrophage apoptosis [MP:0011080](0|0) (0|0|0)
- 1:   increased male germ cell apoptosis [MP:0014052](0|0) (0|0|0)
- 1:   increased otic epithelial cell apoptosis [MP:0008063](0|0) (0|0|0)
- 1:   increased ovary apotosis [MP:0013507](0|0) (0|0|0)
- 1:   increased pancreas apoptosis [MP:0013220](0|0) (0|0|0)
- 1:   increased pancreatic beta cell apoptosis [MP:0014117](0|0) (0|0|0)
- 1:   increased placenta apoptosis [MP:0009658](0|0) (0|0|0)
- 1:   increased small intestinal crypt cell apoptosis [MP:0008800](0|0) (0|0|0)
- 1:   increased splenocyte apoptosis [MP:0009322](0|0) (0|0|0)
- 1:   increased submandibular gland apoptosis [MP:0013540](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SRF-like0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Ran binding protein zinc finger-like0.0001109Direct
STAT0.0001338Direct
Transcription factor STAT-4 N-domain0.0001338Direct
BRCT domain0.0004538Direct
Cullin repeat-like0.000831Direct
Flavoproteins0.002075Inherited
Arginase/deacetylase0.08451Inherited
SH2 domain0.1473Inherited
Rhodanese/Cell cycle control phosphatase0.1889Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.25Inherited
Riboflavin synthase domain-like0.25Inherited
Leucine zipper domain0.6937Inherited
Fibronectin type III0.8053Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Cullin repeat0Direct
Retinoblastoma tumor suppressor domains0Direct
SRF-like0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Ran binding protein zinc finger-like0.00008128Direct
STAT DNA-binding domain0.00009074Direct
STAT0.00009074Direct
Transcription factor STAT-4 N-domain0.00009074Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.000135Direct
SCF ubiquitin ligase complex WHB domain0.000135Direct
NADPH-cytochrome p450 reductase-like0.000135Direct
Histone deacetylase, HDAC0.04309Inherited
SH2 domain0.1316Inherited
Cell cycle control phosphatase, catalytic domain0.2222Inherited
WW domain0.2647Inherited
I set domains0.2909Inherited
Extracellular domain of cell surface receptors0.3644Inherited
ets domain0.3644Inherited
Leucine zipper domain0.6765Inherited
Fibronectin type III0.8219Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
SRF-like0Direct
Ran binding protein zinc finger-like0.00005402Direct
STAT0.0000663Direct
Transcription factor STAT-4 N-domain0.0000663Direct
BRCT domain0.0002382Direct
Cullin repeat-like0.0004492Direct
Flavoproteins0.001182Inherited
Arginase/deacetylase0.06272Inherited
SH2 domain0.1162Inherited
Rhodanese/Cell cycle control phosphatase0.1532Inherited
Riboflavin synthase domain-like0.2098Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2098Inherited
WW domain0.236Inherited
Leucine zipper domain0.6525Inherited
Fibronectin type III0.7708Inherited
Immunoglobulin0.8301Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0000663Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0000663Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0000663Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0001035Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6922Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0000663Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0000663Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)