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Mammalian Phenotype (MP): decreased retinal ganglion cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + + + 9:   vision/eye phenotype [MP:0005391] <2>(43|53) (50|27|17)
+ + + + + + + + 8:   abnormal eye morphology [MP:0002092] <23>(39|49) (46|25|15)
+ + + + + + + 7:   mammalian phenotype [MP:0000001] <29>
+ + + + + + + 7:   abnormal posterior eye segment morphology [MP:0005195] <4>(21|24) (23|14|8)
+ + + + + + 6:   abnormal ocular fundus morphology [MP:0002864] <2>(19|23) (21|14|8)
+ + + + + 5:   nervous system phenotype [MP:0003631] <2>(98|128) (113|79|50)
+ + + + + 5:   abnormal retina morphology [MP:0001325] <23>(19|23) (21|14|8)
+ + + + 4:   abnormal retinal layer morphology [MP:0003727] <3>(11|16) (12|8|6)
+ + + + 4:   abnormal nervous system morphology [MP:0003632] <17>(76|104) (91|64|47)
+ + + + 4:   abnormal somatic nervous system morphology [MP:0002752] <7>(34|47) (37|25|14)
+ + + 3:   abnormal neuron morphology [MP:0002882] <29>(36|59) (40|26|19)
+ + + 3:   abnormal somatic sensory system morphology [MP:0000959] <4>(26|38) (29|19|12)
+ + + 3:   abnormal retinal neuronal layer morphology [MP:0006069] <7>(11|15) (11|8|5)
+ + + 3:   abnormal neuron number [MP:0008946] <3>(8|16) (9|9|8)
+ + 2:   abnormal sensory neuron morphology [MP:0000965] <16>(16|28) (19|14|9)
+ + 2:   decreased neuron number [MP:0008948] <8>(6|11) (6|5|4)
+ + 2:   abnormal retinal ganglion layer morphology [MP:0005241] <5>(2|5) (3|2|1)
+ 1:   abnormal retinal ganglion cell morphology [MP:0008056] <3>(2|5) (3|2|0)
+ 1:   decreased sensory neuron number [MP:0000966] <6>(5|8) (5|3|2)
0:   decreased retinal ganglion cell number [MP:0006309] <1>(2|3) (2|1|0)
- 1:   absent retinal ganglion cell [MP:0008068](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
E2F-DP heterodimerization region0.000001206Direct
Cyclin-like0.0002357Direct


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
E2F dimerization segment0.0000004517Direct
Cell cycle transcription factor e2f-dp0.000003206Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
E2F-DP heterodimerization region0.0000004931Direct
Cyclin-like0.0001195Direct

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0000004931Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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