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Mammalian Phenotype (MP): abnormal T cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + + 8:   mammalian phenotype [MP:0000001] <29>
+ + + + + + 6:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + + + 6:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + + 5:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ + + + + 5:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + + + 4:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
+ + + + 4:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)
+ + + 3:   abnormal leukocyte morphology [MP:0008246] <4>(36|62) (47|29|15)
+ + + 3:   abnormal mononuclear cell morphology [MP:0008247] <2>(33|57) (41|28|14)
+ + + 3:   abnormal hematopoietic cell number [MP:0011180] <7>(34|57) (43|29|13)
+ + 2:   abnormal leukocyte cell number [MP:0000217] <8>(29|49) (37|25|12)
+ + 2:   abnormal lymphocyte morphology [MP:0002619] <5>(27|46) (33|26|14)
+ 1:   abnormal lymphocyte cell number [MP:0000717] <6>(18|38) (25|21|9)
+ 1:   abnormal T cell morphology [MP:0008037] <9>(14|25) (18|19|11)
0:   abnormal T cell number [MP:0006387] <11>(8|22) (16|15|7)
- 1:   decreased T cell number [MP:0005018] <12>(8|15) (13|11|5)
- 1:   increased T cell number [MP:0005015] <11>(0|2) (2|1|1)
- 1:   abnormal gamma-delta T cell number [MP:0008345] <6>(0|0) (0|0|0)
- 1:   abnormal NK T cell number [MP:0008038] <5>(0|0) (0|0|0)
- 1:   abnormal alpha-beta T cell number [MP:0012763] <5>(3|11) (4|8|2)
- 1:   abnormal memory T cell number [MP:0008048] <5>(0|0) (0|0|0)
- 1:   abnormal CD5-positive T cell number [MP:0013687] <3>(0|0) (0|0|0)
- 1:   abnormal regulatory T cell number [MP:0004972] <3>(0|0) (0|0|0)
- 1:   abnormal effector T cell number [MP:0013762] <2>(0|1) (0|0|0)
- 1:   abnormal intraepithelial T cell number [MP:0008895] <2>(0|0) (0|0|0)
- 1:   abnormal T cell subpopulation ratio [MP:0003944](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
MHC antigen-recognition domain0.00001996Direct
Integrin domains0.001723Inherited
E2F-DP heterodimerization region0.002959Inherited
Integrin alpha N-terminal domain0.003753Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.004495Inherited
SH2 domain0.636Inherited
DEATH domain0.9204Inherited
Cysteine-rich domain0.9238Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
Proteasome subunits0Direct
Interleukin 17F, IL-17F0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000004054Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.000002728Direct
MHC antigen-recognition domain0.00001249Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.00001564Direct
E2F dimerization segment0.0007649Direct
Bcl-2 inhibitors of programmed cell death0.0009042Direct
Interferon regulatory factor0.0009042Direct
Integrin domains0.001212Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.001991Inherited
Nuclear receptor coactivator interlocking domain0.004166Inherited
Cell cycle transcription factor e2f-dp0.007231Inherited
C1 set domains (antibody constant domain-like)0.02231Inherited
SH3-domain0.2124Inherited
V set domains (antibody variable domain-like)0.3477Inherited
SH2 domain0.5633Inherited
Pointed domain0.6182Inherited
TNF receptor-like0.7111Inherited
ets domain0.7116Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.8298Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
MHC antigen-recognition domain0.000008933Direct
Bcl-2 inhibitors of programmed cell death0.0007641Direct
Integrin domains0.0009719Direct
E2F-DP heterodimerization region0.001715Inherited
Integrin alpha N-terminal domain0.0022Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.002664Inherited
Nuclear receptor coactivator interlocking domain0.003659Inherited
beta-beta-alpha zinc fingers0.009573Inherited
p53-like transcription factors0.01506Inherited
SH3-domain0.2283Inherited
Protein kinase-like (PK-like)0.3149Inherited
Acyl-CoA N-acyltransferases (Nat)0.3789Inherited
SH2 domain0.5916Inherited
DEATH domain0.8953Inherited
Cysteine-rich domain0.8992Inherited
TNF receptor-like0.9459Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000002786Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0000008219Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00001603Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.001715Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.001715Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.001785Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.001785Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.006303Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.02356Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.03256Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.06508Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.207Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.524Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.6228Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.001715Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.001785Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.02356Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.3503Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3503Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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