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Mammalian Phenotype (MP): abnormal mononuclear cell morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + 4:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + 3:   abnormal immune system morphology [MP:0000685] <3>(51|76) (60|35|18)
+ + + 3:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
+ + 2:   abnormal hematopoietic cell morphology [MP:0013656] <9>(49|77) (60|43|18)
+ + 2:   abnormal immune system cell morphology [MP:0000716] <5>(38|63) (48|29|16)
+ 1:   abnormal leukocyte morphology [MP:0008246] <4>(37|62) (47|29|15)
0:   abnormal mononuclear cell morphology [MP:0008247] <2>(34|57) (41|28|14)
- 1:   abnormal lymphocyte morphology [MP:0002619] <5>(28|46) (33|26|14)
- 1:   abnormal mononuclear phagocyte morphology [MP:0008248] <3>(6|14) (8|5|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
TNF receptor-like0.0000000009162Direct
p53-like transcription factors0.00002864Direct
MHC antigen-recognition domain0.0006216Direct
DNA polymerase beta, N-terminal domain-like0.003397Inherited
Flavoproteins0.003675Inherited
BRCT domain0.004511Inherited
Triple coiled coil domain of C-type lectins0.01191Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01266Inherited
Bcl-2 inhibitors of programmed cell death0.01792Inherited
E2F-DP heterodimerization region0.02511Inherited
SH2 domain0.02731Inherited
WWE domain0.102Inherited
SMAD/FHA domain0.1542Inherited
SH3-domain0.1671Inherited
DNA/RNA polymerases0.1678Inherited
Nuclear receptor ligand-binding domain0.1914Inherited
Cysteine-rich domain0.2282Inherited
Nucleotidyltransferase0.2464Inherited
Riboflavin synthase domain-like0.2881Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2881Inherited
DEATH domain0.3459Inherited
Calponin-homology domain, CH-domain0.4631Inherited
Integrin alpha N-terminal domain0.4634Inherited
Ran binding protein zinc finger-like0.5056Inherited
Immunoglobulin0.5645Inherited
Integrin domains0.6463Inherited
DBL homology domain (DH-domain)0.6463Inherited
Toll/Interleukin receptor TIR domain0.7197Inherited
SET domain0.9599Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Proteasome subunits0Direct
STAT DNA-binding domain0Direct
RUNT domain0Direct
DNA polymerase beta-like0Direct
BAFF receptor-like0Direct
Transcription factor STAT-4 N-domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
STAT0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
TNF receptor-like0.000000008195Direct
C1 set domains (antibody constant domain-like)0.0000002303Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000529Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0004088Direct
MHC antigen-recognition domain0.0004192Direct
DEATH domain, DD0.0006132Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001214Inherited
DNA polymerase beta, N-terminal domain-like0.002275Inherited
Pointed domain0.002502Inherited
E2F dimerization segment0.008289Inherited
beta-glycanases0.008465Inherited
Triple coiled coil domain of C-type lectins0.008465Inherited
Cytochrome p450 reductase N-terminal domain-like0.008465Inherited
Bcl-2 inhibitors of programmed cell death0.01338Inherited
Interferon regulatory factor0.01338Inherited
C2 set domains0.01338Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.0189Inherited
SH2 domain0.02066Inherited
NADPH-cytochrome p450 reductase-like0.02527Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02527Inherited
Nuclear receptor coactivator interlocking domain0.02527Inherited
Tetraspanin0.02527Inherited
Pleckstrin-homology domain (PH domain)0.02721Inherited
Myb/SANT domain0.03416Inherited
Long-chain cytokines0.03629Inherited
WWE domain0.05088Inherited
DNA polymerase I0.05088Inherited
Cell cycle transcription factor e2f-dp0.05551Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.08371Inherited
MATH domain0.1116Inherited
SH3-domain0.1429Inherited
Nuclear receptor ligand-binding domain0.1635Inherited
Nuclear receptor0.1635Inherited
PLC-like (P variant)0.2908Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2908Inherited
Caspase recruitment domain, CARD0.3039Inherited
ets domain0.3205Inherited
FHA domain0.3326Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.3877Inherited
V set domains (antibody variable domain-like)0.4231Inherited
Calponin-homology domain, CH-domain0.4438Inherited
Ran binding protein zinc finger-like0.4701Inherited
DBL homology domain (DH-domain)0.615Inherited
Integrin domains0.615Inherited
CCCH zinc finger0.6269Inherited
Toll/Interleukin receptor TIR domain0.7298Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.0000000003393Direct
p53-like transcription factors0.00001314Direct
MHC antigen-recognition domain0.0003306Direct
DNA polymerase beta, N-terminal domain-like0.001982Inherited
Flavoproteins0.002157Inherited
BRCT domain0.002675Inherited
TNF-like0.003012Inherited
Triple coiled coil domain of C-type lectins0.007536Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.008045Inherited
Bcl-2 inhibitors of programmed cell death0.01168Inherited
E2F-DP heterodimerization region0.01679Inherited
SH2 domain0.01839Inherited
Nuclear receptor coactivator interlocking domain0.02301Inherited
beta-beta-alpha zinc fingers0.05642Inherited
WWE domain0.07719Inherited
SMAD/FHA domain0.1225Inherited
SH3-domain0.1336Inherited
DNA/RNA polymerases0.1343Inherited
Nuclear receptor ligand-binding domain0.1555Inherited
Protein kinase-like (PK-like)0.1771Inherited
Cysteine-rich domain0.1894Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1906Inherited
Nucleotidyltransferase0.2065Inherited
Riboflavin synthase domain-like0.2456Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2456Inherited
DEATH domain0.3006Inherited
Calponin-homology domain, CH-domain0.4154Inherited
Integrin alpha N-terminal domain0.4157Inherited
Ran binding protein zinc finger-like0.458Inherited
Immunoglobulin0.5179Inherited
DBL homology domain (DH-domain)0.6027Inherited
Integrin domains0.6027Inherited
CCCH zinc finger0.6161Inherited
Acyl-CoA N-acyltransferases (Nat)0.6372Inherited
Toll/Interleukin receptor TIR domain0.68Inherited
SET domain0.9398Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.00000005293Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000007451Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00002983Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00004137Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0005013Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0005013Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0006084Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.001813Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.007536Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.007536Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.01679Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.01679Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.05043Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1137Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1195Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1406Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.209Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.458Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.458Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.6027Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.68Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000006408Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001002Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.007536Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01679Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.458Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.68Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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