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Mammalian Phenotype (MP): abnormal protein level

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ 1:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
0:   abnormal protein level [MP:0008469] <15>(23|31) (25|13|3)
- 1:   abnormal circulating protein level [MP:0005416] <24>(18|25) (20|10|3)
- 1:   abnormal acute phase protein level [MP:0010211] <3>(1|1) (1|1|0)
- 1:   abnormal intercellular signaling peptide or protein level [MP:0008835] <3>(12|19) (12|9|3)
- 1:   abnormal UDP-N-acetylglucosamine-1-phosphotransferase level [MP:0020297] <2>(0|0) (0|0|0)
- 1:   abnormal alpha-fetoprotein level [MP:0012600] <2>(0|0) (0|0|0)
- 1:   abnormal collagen level [MP:0020252] <2>(0|0) (0|0|0)
- 1:   abnormal complement protein level [MP:0011566] <2>(0|0) (0|0|0)
- 1:   abnormal dystrophin level [MP:0020291] <2>(0|0) (0|0|0)
- 1:   abnormal guanylate cyclase activating protein-2 level [MP:0020294] <2>(0|0) (0|0|0)
- 1:   abnormal haptoglobin level [MP:0013215] <2>(0|0) (0|0|0)
- 1:   abnormal phospholipase A2 level [MP:0012044] <2>(0|0) (0|0|0)
- 1:   abnormal apolipoprotein level [MP:0010331] <1>(0|0) (0|0|0)
- 1:   abnormal renal protein reabsorption [MP:0011445] <1>(2|2) (2|0|0)
- 1:   proteinosis [MP:0010999] <1>(0|0) (0|0|0)
- 1:   abnormal cholinesterase level [MP:0012047](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.0000004182Direct
C-type lectin-like0.000009216Direct
STAT0.00001725Direct
Transcription factor STAT-4 N-domain0.00001725Direct
Toll/Interleukin receptor TIR domain0.00001942Direct
4-helical cytokines0.0001878Direct
Triple coiled coil domain of C-type lectins0.003164Inherited
Fibronectin type III0.004724Inherited
Clc chloride channel0.0149Inherited
SH2 domain0.02209Inherited
FAS1 domain0.03694Inherited
Flavoproteins0.04403Inherited
Caspase-like0.05225Inherited
CBS-domain pair0.07696Inherited
Kringle-like0.101Inherited
p53-like transcription factors0.1339Inherited
Immunoglobulin0.1438Inherited
CCCH zinc finger0.1485Inherited
Riboflavin synthase domain-like0.263Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.263Inherited
E set domains0.3038Inherited
CAD & PB1 domains0.3184Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
STAT DNA-binding domain0.0000108Direct
Transcription factor STAT-4 N-domain0.0000108Direct
STAT0.0000108Direct
Toll/Interleukin receptor TIR domain0.00005346Direct
Pyrin domain, PYD0.0003259Direct
Interleukin-1 (IL-1)0.0003989Direct
C-type lectin domain0.000503Direct
DEATH domain, DD0.0007531Direct
Triple coiled coil domain of C-type lectins0.002183Inherited
28-residue LRR0.002653Inherited
Interferon regulatory factor0.003915Inherited
Fibronectin type III0.004857Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.01053Inherited
NADPH-cytochrome p450 reductase-like0.01053Inherited
Clc chloride channel0.01053Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01053Inherited
Interferons/interleukin-10 (IL-10)0.01368Inherited
SH2 domain0.01722Inherited
FAS1 domain0.02725Inherited
Long-chain cytokines0.03301Inherited
Caspase catalytic domain0.03312Inherited
TNF receptor-like0.05298Inherited
CBS-domain pair0.06096Inherited
Kringle modules0.07219Inherited
Notch domain0.07435Inherited
p120GAP domain-like0.08156Inherited
Caspase recruitment domain, CARD0.1086Inherited
CCCH zinc finger0.1302Inherited
Growth factor receptor domain0.2983Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.0000001689Direct
C-type lectin-like0.000004028Direct
STAT0.00000768Direct
Transcription factor STAT-4 N-domain0.00000768Direct
Toll/Interleukin receptor TIR domain0.000008688Direct
4-helical cytokines0.00009447Direct
Triple coiled coil domain of C-type lectins0.001843Inherited
Fibronectin type III0.002817Inherited
Clc chloride channel0.009556Inherited
SH2 domain0.01461Inherited
FAS1 domain0.02547Inherited
Flavoproteins0.03078Inherited
Caspase-like0.03702Inherited
CBS-domain pair0.05665Inherited
Glycosyl hydrolase domain0.06452Inherited
Notch domain0.0699Inherited
Kringle-like0.07629Inherited
p53-like transcription factors0.1047Inherited
Immunoglobulin0.1133Inherited
CCCH zinc finger0.1173Inherited
Riboflavin synthase domain-like0.2217Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2217Inherited
E set domains0.2604Inherited
CAD & PB1 domains0.2742Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.00000768Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000768Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000768Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.00002538Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.001843Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.006679Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.006679Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.009556Inherited
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0.02547Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.05665Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.06452Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1097Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000768Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000768Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)