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Mammalian Phenotype (MP): abnormal interferon secretion

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + 3:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + 2:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (31|24|12)
+ 1:   abnormal cytokine secretion [MP:0003009] <4>(17|33) (23|19|8)
0:   abnormal interferon secretion [MP:0008555] <3>(9|17) (11|11|3)
- 1:   abnormal interferon-alpha secretion [MP:0008557] <2>(2|1) (3|0|0)
- 1:   abnormal interferon-beta secretion [MP:0008558] <2>(1|1) (2|0|0)
- 1:   abnormal interferon-gamma secretion [MP:0008559] <2>(6|15) (7|11|3)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
MHC antigen-recognition domain0.001022Inherited
TNF-like0.01365Inherited
SMAD/FHA domain0.03819Inherited
TNF receptor-like0.1431Inherited
DEATH domain0.1721Inherited
STAT0.2317Inherited
Transcription factor STAT-4 N-domain0.2317Inherited
SH2 domain0.2732Inherited
Toll/Interleukin receptor TIR domain0.9187Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Interferon regulatory factor0.0000001344Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.0000006342Direct
MHC antigen-recognition domain0.0006736Direct
Short-chain cytokines0.0009178Direct
TNF-like0.008253Inherited
C1 set domains (antibody constant domain-like)0.0437Inherited
Pyrin domain, PYD0.07498Inherited
Interleukin-1 (IL-1)0.1273Inherited
TNF receptor-like0.1574Inherited
STAT DNA-binding domain0.1876Inherited
STAT0.1876Inherited
Transcription factor STAT-4 N-domain0.1876Inherited
SH2 domain0.2114Inherited
Caspase recruitment domain, CARD0.2536Inherited
V set domains (antibody variable domain-like)0.3134Inherited
PLC-like (P variant)0.36Inherited
Toll/Interleukin receptor TIR domain0.9322Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
MHC antigen-recognition domain0.0005591Direct
TNF-like0.008721Inherited
SMAD/FHA domain0.0264Inherited
"Winged helix" DNA-binding domain0.08601Inherited
TNF receptor-like0.1126Inherited
DEATH domain0.1381Inherited
STAT0.1927Inherited
Transcription factor STAT-4 N-domain0.1927Inherited
SH2 domain0.2315Inherited
Toll/Interleukin receptor TIR domain0.8934Inherited
RNI-like0.9572Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.000004428Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0002167Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0003423Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0264Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1635Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.1927Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.1927Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.1927Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.3274Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3387Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.1927Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.1927Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)