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Mammalian Phenotype (MP): abnormal interferon-gamma secretion

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <29>
+ + + + + 5:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + + 3:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (31|24|12)
+ + 2:   abnormal cytokine secretion [MP:0003009] <4>(17|33) (23|19|8)
+ 1:   abnormal interferon secretion [MP:0008555] <3>(9|17) (11|11|3)
0:   abnormal interferon-gamma secretion [MP:0008559] <2>(6|15) (7|11|3)
- 1:   decreased interferon-gamma secretion [MP:0008567](0|2) (1|2|1)
- 1:   increased interferon-gamma secretion [MP:0008566](2|3) (2|3|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SH2 domain0.0000000001055Direct
TNF receptor-like0.000006668Direct
STAT0.00003291Direct
Transcription factor STAT-4 N-domain0.00003291Direct
TNF-like0.00007632Direct
MHC antigen-recognition domain0.0005974Direct


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
SH2 domain0.00000000009131Direct
TNF receptor-like0.00001102Direct
Caspase recruitment domain, CARD0.00001102Direct
STAT DNA-binding domain0.00001967Direct
STAT0.00001967Direct
Pyrin domain, PYD0.00001967Direct
Transcription factor STAT-4 N-domain0.00001967Direct
V set domains (antibody variable domain-like)0.00003806Direct
TNF-like0.00005073Direct
Interleukin-1 (IL-1)0.0001088Direct
MHC antigen-recognition domain0.0003967Direct
C1 set domains (antibody constant domain-like)0.00052Direct
Short-chain cytokines0.0005842Direct
PLC-like (P variant)0.001588Inherited
Toll/Interleukin receptor TIR domain0.9189Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SH2 domain0.00000000003854Direct
TNF receptor-like0.000002865Direct
STAT0.00001513Direct
Transcription factor STAT-4 N-domain0.00001513Direct
TNF-like0.00003646Direct
MHC antigen-recognition domain0.0003172Direct
Toll/Interleukin receptor TIR domain0.9817Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.000002287Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00001513Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.00001513Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00001513Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.00004767Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0001194Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0002263Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.000227Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0003285Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0004378Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00001513Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00001513Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)