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Mammalian Phenotype (MP): abnormal interleukin secretion

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + 3:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + 2:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (31|24|12)
+ 1:   abnormal cytokine secretion [MP:0003009] <4>(17|33) (23|19|8)
0:   abnormal interleukin secretion [MP:0008568] <19>(13|26) (17|15|7)
- 1:   abnormal interleukin-1 secretion [MP:0008650] <4>(4|6) (4|2|0)
- 1:   abnormal interleukin-12 secretion [MP:0008662] <3>(1|2) (1|0|0)
- 1:   abnormal interleukin-23 secretion [MP:0008689] <3>(0|0) (0|0|0)
- 1:   abnormal interleukin-10 secretion [MP:0008659] <2>(3|3) (3|3|1)
- 1:   abnormal interleukin-12b secretion [MP:0008668] <2>(3|1) (3|0|0)
- 1:   abnormal interleukin-13 secretion [MP:0008671] <2>(0|0) (0|0|0)
- 1:   abnormal interleukin-15 secretion [MP:0008674] <2>(0|0) (0|0|0)
- 1:   abnormal interleukin-16 secretion [MP:0008677] <2>(0|0) (0|0|0)
- 1:   abnormal interleukin-17 secretion [MP:0008680] <2>(0|1) (1|0|0)
- 1:   abnormal interleukin-18 secretion [MP:0008683] <2>(1|1) (1|0|0)
- 1:   abnormal interleukin-2 secretion [MP:0008686] <2>(3|7) (5|5|1)
- 1:   abnormal interleukin-21 secretion [MP:0009056] <2>(0|0) (0|0|0)
- 1:   abnormal interleukin-3 secretion [MP:0008695] <2>(0|0) (0|0|0)
- 1:   abnormal interleukin-4 secretion [MP:0008698] <2>(0|0) (0|0|2)
- 1:   abnormal interleukin-5 secretion [MP:0008701] <2>(0|1) (0|1|1)
- 1:   abnormal interleukin-6 secretion [MP:0008704] <2>(2|2) (3|1|0)
- 1:   abnormal interleukin-7 secretion [MP:0008707] <2>(0|0) (0|0|0)
- 1:   abnormal interleukin-8 secretion [MP:0011716] <2>(0|0) (0|0|0)
- 1:   abnormal interleukin-9 secretion [MP:0008710] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
STAT0.0000001324Direct
Transcription factor STAT-4 N-domain0.0000001324Direct
Transducin (alpha subunit), insertion domain0.001896Inherited
Caspase-like0.004537Inherited
DEATH domain0.02543Inherited
TNF-like0.1802Inherited
4-helical cytokines0.1834Inherited
RNI-like0.1834Inherited
Toll/Interleukin receptor TIR domain0.1962Inherited
DBL homology domain (DH-domain)0.2649Inherited
L domain-like0.3088Inherited
SH3-domain0.3933Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Interleukin 17F, IL-17F0Direct
DEATH domain, DD0.00000006121Direct
STAT DNA-binding domain0.00000008297Direct
STAT0.00000008297Direct
Transcription factor STAT-4 N-domain0.00000008297Direct
TNF receptor-like0.0000001007Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000001925Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0000004148Direct
Pyrin domain, PYD0.000006723Direct
28-residue LRR0.00002602Direct
Notch domain0.0006746Direct
Transducin (alpha subunit), insertion domain0.00137Inherited
Short-chain cytokines0.00469Inherited
Caspase catalytic domain0.0153Inherited
TNF-like0.1457Inherited
Toll/Interleukin receptor TIR domain0.185Inherited
DBL homology domain (DH-domain)0.2247Inherited
Interferons/interleukin-10 (IL-10)0.2785Inherited
SH3-domain0.3443Inherited
Caspase recruitment domain, CARD0.3447Inherited
EF-hand modules in multidomain proteins0.3464Inherited
Pleckstrin-homology domain (PH domain)0.4283Inherited
Interleukin-1 (IL-1)0.4287Inherited
RING finger domain, C3HC40.6247Inherited
PLC-like (P variant)0.7678Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
STAT0.00000005226Direct
Transcription factor STAT-4 N-domain0.00000005226Direct
Notch domain0.0005569Direct
Transducin (alpha subunit), insertion domain0.001075Inherited
Caspase-like0.002693Inherited
DEATH domain0.01701Inherited
Cystine-knot cytokines0.1292Inherited
TNF-like0.1454Inherited
4-helical cytokines0.1483Inherited
RNI-like0.1483Inherited
Toll/Interleukin receptor TIR domain0.1598Inherited
DBL homology domain (DH-domain)0.2236Inherited
L domain-like0.265Inherited
SH3-domain0.3469Inherited
RING/U-box0.4939Inherited
PH domain-like0.9005Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000005226Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.00000005226Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000005226Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000001181Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000001054Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00001632Direct
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.00016Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.001326Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.005232Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.2774Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.3435Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.4026Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.4263Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.9509Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000005226Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000005226Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0005569Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.022Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4263Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.7085Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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