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Mammalian Phenotype (MP): abnormal circulating interleukin level

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   mammalian phenotype [MP:0000001] <29>
+ + + + + 5:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + + + + 5:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + + + 4:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ + + 3:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (31|24|12)
+ + + 3:   abnormal intercellular signaling peptide or protein level [MP:0008835] <3>(12|19) (12|9|3)
+ + + 3:   abnormal protein level [MP:0008469] <15>(23|31) (25|13|3)
+ + + 3:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
+ + 2:   abnormal circulating protein level [MP:0005416] <24>(18|25) (20|10|3)
+ + 2:   abnormal cytokine level [MP:0008713] <5>(11|18) (11|7|2)
+ 1:   abnormal interleukin level [MP:0008751] <1>(8|11) (8|6|2)
+ 1:   abnormal circulating cytokine level [MP:0010210] <4>(10|17) (10|6|2)
0:   abnormal circulating interleukin level [MP:0008588] <19>(7|11) (7|6|2)
- 1:   abnormal circulating interleukin-1 level [MP:0008589] <4>(0|1) (0|0|0)
- 1:   abnormal circulating interleukin-12 level [MP:0008616] <3>(1|1) (1|0|0)
- 1:   abnormal circulating interleukin-23 level [MP:0008619] <3>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-10 level [MP:0008590] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-12b level [MP:0008646] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-13 level [MP:0008607] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-15 level [MP:0008610] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-16 level [MP:0008631] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-17 level [MP:0008613] <2>(2|1) (2|1|0)
- 1:   abnormal circulating interleukin-18 level [MP:0008634] <2>(2|3) (2|1|0)
- 1:   abnormal circulating interleukin-2 level [MP:0008598] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-21 level [MP:0009059] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-3 level [MP:0008622] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-4 level [MP:0008601] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-5 level [MP:0008625] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-6 level [MP:0008595] <2>(1|2) (1|0|0)
- 1:   abnormal circulating interleukin-7 level [MP:0008604] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-8 level [MP:0011713] <2>(0|0) (0|0|0)
- 1:   abnormal circulating interleukin-9 level [MP:0008628] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0.000000001418Direct
Transcription factor STAT-4 N-domain0.000000001418Direct
Caspase-like0.004081Inherited
DEATH domain0.00605Inherited
SH2 domain0.1702Inherited
4-helical cytokines0.628Inherited
Toll/Interleukin receptor TIR domain0.6795Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT DNA-binding domain0.000000001041Direct
STAT0.000000001041Direct
Transcription factor STAT-4 N-domain0.000000001041Direct
Interleukin-1 (IL-1)0.0000008254Direct
DEATH domain, DD0.000002932Direct
Pyrin domain, PYD0.00001282Direct
28-residue LRR0.00009446Direct
Caspase recruitment domain, CARD0.001027Inherited
Caspase catalytic domain0.002304Inherited
SH2 domain0.1349Inherited
Toll/Interleukin receptor TIR domain0.7065Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
STAT0.0000000005277Direct
Transcription factor STAT-4 N-domain0.0000000005277Direct
Caspase-like0.002408Inherited
DEATH domain0.003659Inherited
SH2 domain0.1363Inherited
4-helical cytokines0.5834Inherited
Toll/Interleukin receptor TIR domain0.6376Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0000000005277Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0000000005277Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0000000005277Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0001462Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0005205Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.09133Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0000000005277Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0000000005277Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)