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Mammalian Phenotype (MP): abnormal interleukin-1 beta secretion

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   mammalian phenotype [MP:0000001] <29>
+ + + + + + 6:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + + 5:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + + + 4:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (32|24|12)
+ + + 3:   abnormal cytokine secretion [MP:0003009] <4>(17|33) (23|19|8)
+ + 2:   abnormal interleukin secretion [MP:0008568] <19>(13|26) (17|15|7)
+ 1:   abnormal interleukin-1 secretion [MP:0008650] <4>(4|6) (4|2|0)
0:   abnormal interleukin-1 beta secretion [MP:0008656] <2>(4|6) (4|2|0)
- 1:   decreased interleukin-1 beta secretion [MP:0008658](0|1) (0|0|0)
- 1:   increased interleukin-1 beta secretion [MP:0008657](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DEATH domain0.000000000006304Direct
RNI-like0.000001698Direct
Toll/Interleukin receptor TIR domain0.000004313Direct
Caspase-like0.0001401Direct


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Caspase recruitment domain, CARD0.000000005777Direct
Interleukin-1 (IL-1)0.000001675Direct
Toll/Interleukin receptor TIR domain0.000002427Direct
Pyrin domain, PYD0.00000974Direct
28-residue LRR0.00001188Direct
Caspase catalytic domain0.00006902Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DEATH domain0.000000000002284Direct
RNI-like0.0000006993Direct
Toll/Interleukin receptor TIR domain0.00000184Direct
Caspase-like0.0000696Direct

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.000002989Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00001238Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)