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Mammalian Phenotype (MP): abnormal interleukin-2 secretion

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <29>
+ + + + + 5:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + + 3:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (32|24|12)
+ + 2:   abnormal cytokine secretion [MP:0003009] <4>(17|33) (23|19|8)
+ 1:   abnormal interleukin secretion [MP:0008568] <19>(13|26) (17|15|7)
0:   abnormal interleukin-2 secretion [MP:0008686] <2>(3|7) (5|5|1)
- 1:   decreased interleukin-2 secretion [MP:0008688](2|4) (3|4|1)
- 1:   increased interleukin-2 secretion [MP:0008687](1|3) (2|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SH3-domain0.0004401Direct
DBL homology domain (DH-domain)0.005885Inherited
Transducin (alpha subunit), insertion domain0.09381Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
SH3-domain0.0003327Direct
Pleckstrin-homology domain (PH domain)0.00187Inherited
DBL homology domain (DH-domain)0.004247Inherited
RING finger domain, C3HC40.0137Inherited
EF-hand modules in multidomain proteins0.0287Inherited
PLC-like (P variant)0.07288Inherited
Transducin (alpha subunit), insertion domain0.0778Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SH3-domain0.0002311Direct
DBL homology domain (DH-domain)0.003547Inherited
PH domain-like0.02077Inherited
Transducin (alpha subunit), insertion domain0.07033Inherited
RING/U-box0.07701Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.000002712Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.009629Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02565Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.06502Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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