SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal cytokine level

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + + 3:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + 3:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ + 2:   abnormal protein level [MP:0008469] <15>(23|31) (25|13|3)
+ + 2:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ 1:   abnormal intercellular signaling peptide or protein level [MP:0008835] <3>(12|19) (12|9|3)
+ 1:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (31|24|12)
0:   abnormal cytokine level [MP:0008713] <5>(11|18) (11|7|2)
- 1:   abnormal circulating cytokine level [MP:0010210] <4>(10|17) (10|6|2)
- 1:   abnormal chemokine level [MP:0008721] <1>(0|0) (0|0|0)
- 1:   abnormal interferon level [MP:0008750] <1>(7|6) (7|4|2)
- 1:   abnormal interleukin level [MP:0008751] <1>(8|11) (8|6|2)
- 1:   abnormal tumor necrosis factor level [MP:0008752] <1>(1|1) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
STAT0.00000005341Direct
Transcription factor STAT-4 N-domain0.00000005341Direct
Triple coiled coil domain of C-type lectins0.0001823Direct
Fibronectin type III0.001305Inherited
4-helical cytokines0.007665Inherited
CCCH zinc finger0.01784Inherited
DEATH domain0.02053Inherited
p53-like transcription factors0.03471Inherited
Toll/Interleukin receptor TIR domain0.2004Inherited
Caspase-like0.2093Inherited
SH2 domain0.7Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
STAT DNA-binding domain0.00000003829Direct
STAT0.00000003829Direct
Transcription factor STAT-4 N-domain0.00000003829Direct
Interleukin-1 (IL-1)0.000009244Direct
Triple coiled coil domain of C-type lectins0.0001224Direct
Long-chain cytokines0.0005506Direct
Fibronectin type III0.001199Inherited
CCCH zinc finger0.01459Inherited
Pyrin domain, PYD0.02073Inherited
DEATH domain, DD0.0343Inherited
Caspase catalytic domain0.07884Inherited
28-residue LRR0.07921Inherited
Interferons/interleukin-10 (IL-10)0.1115Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1115Inherited
Interferon regulatory factor0.1285Inherited
Toll/Interleukin receptor TIR domain0.2526Inherited
Caspase recruitment domain, CARD0.5139Inherited
SH2 domain0.714Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
STAT0.00000002062Direct
Transcription factor STAT-4 N-domain0.00000002062Direct
Triple coiled coil domain of C-type lectins0.00009168Direct
Fibronectin type III0.0007243Direct
4-helical cytokines0.004708Inherited
CCCH zinc finger0.01162Inherited
DEATH domain0.0135Inherited
p53-like transcription factors0.02386Inherited
Toll/Interleukin receptor TIR domain0.1636Inherited
Caspase-like0.1718Inherited
SH2 domain0.6591Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000002062Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.00000002062Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000002062Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.00009168Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.004273Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0705Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.09911Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000002062Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000002062Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)