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Mammalian Phenotype (MP): abnormal intercellular signaling peptide or protein level

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + 2:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ 1:   abnormal protein level [MP:0008469] <15>(23|31) (25|13|3)
0:   abnormal intercellular signaling peptide or protein level [MP:0008835] <3>(12|19) (12|9|3)
- 1:   abnormal cytokine level [MP:0008713] <5>(11|18) (11|7|2)
- 1:   abnormal transforming growth factor beta level [MP:0008836] <2>(0|0) (0|0|0)
- 1:   abnormal bradykinin level [MP:0009812](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0.00000006403Direct
Transcription factor STAT-4 N-domain0.00000006403Direct
p53-like transcription factors0.000001375Direct
DEATH domain0.000005866Direct
SH2 domain0.00004704Direct
Triple coiled coil domain of C-type lectins0.0002003Direct
4-helical cytokines0.0002831Direct
Fibronectin type III0.0004972Direct
Toll/Interleukin receptor TIR domain0.0007059Direct
Immunoglobulin0.0008553Direct
CCCH zinc finger0.01927Inherited
Caspase-like0.1122Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT DNA-binding domain0.00000004708Direct
STAT0.00000004708Direct
Transcription factor STAT-4 N-domain0.00000004708Direct
Pyrin domain, PYD0.000004254Direct
Interleukin-1 (IL-1)0.00001062Direct
Interferon regulatory factor0.00003656Direct
SH2 domain0.00004108Direct
Triple coiled coil domain of C-type lectins0.0001363Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.0001424Direct
TNF receptor-like0.000162Direct
Fibronectin type III0.0004806Direct
Interferons/interleukin-10 (IL-10)0.0005972Direct
Long-chain cytokines0.0006328Direct
Toll/Interleukin receptor TIR domain0.001079Inherited
Caspase recruitment domain, CARD0.008124Inherited
DEATH domain, DD0.009647Inherited
28-residue LRR0.01522Inherited
CCCH zinc finger0.01589Inherited
Caspase catalytic domain0.09705Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
STAT0.00000002496Direct
Transcription factor STAT-4 N-domain0.00000002496Direct
p53-like transcription factors0.0000005632Direct
DEATH domain0.000002527Direct
SH2 domain0.00002207Direct
Triple coiled coil domain of C-type lectins0.0001013Direct
4-helical cytokines0.0001452Direct
Fibronectin type III0.0002624Direct
Toll/Interleukin receptor TIR domain0.0003777Direct
Immunoglobulin0.0004633Direct
CCCH zinc finger0.01261Inherited
Caspase-like0.08594Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000002496Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.00000002496Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000002496Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.0001013Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0001752Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0002262Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0004972Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.08594Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000002496Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000002496Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)