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Mammalian Phenotype (MP): abnormal circulating cytokine level

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + + 3:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + + 3:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ + 2:   abnormal protein level [MP:0008469] <15>(23|31) (25|13|3)
+ + 2:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
+ + 2:   abnormal intercellular signaling peptide or protein level [MP:0008835] <3>(12|19) (12|9|3)
+ + 2:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (32|24|12)
+ 1:   abnormal circulating protein level [MP:0005416] <24>(18|25) (20|10|3)
+ 1:   abnormal cytokine level [MP:0008713] <5>(11|18) (11|7|2)
0:   abnormal circulating cytokine level [MP:0010210] <4>(10|17) (10|6|2)
- 1:   abnormal circulating interleukin level [MP:0008588] <19>(7|11) (7|6|2)
- 1:   abnormal circulating interferon level [MP:0008548] <3>(7|6) (7|4|2)
- 1:   abnormal circulating tumor necrosis factor level [MP:0008552] <2>(1|1) (1|0|0)
- 1:   abnormal circulating chemokine level [MP:0010209](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0.000000008548Direct
Transcription factor STAT-4 N-domain0.000000008548Direct
Fibronectin type III0.000002524Direct
4-helical cytokines0.00002164Direct
DEATH domain0.0001315Direct
SH2 domain0.0002386Direct
Toll/Interleukin receptor TIR domain0.0007583Direct
CCCH zinc finger0.008611Inherited
p53-like transcription factors0.01213Inherited
Caspase-like0.05531Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT DNA-binding domain0.000000006457Direct
Transcription factor STAT-4 N-domain0.000000006457Direct
STAT0.000000006457Direct
Fibronectin type III0.000002589Direct
Interleukin-1 (IL-1)0.000002798Direct
Interferon regulatory factor0.000007849Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.00004079Direct
Long-chain cytokines0.0001573Direct
Interferons/interleukin-10 (IL-10)0.0001828Direct
SH2 domain0.0002128Direct
Toll/Interleukin receptor TIR domain0.001368Inherited
Caspase recruitment domain, CARD0.002816Inherited
CCCH zinc finger0.006936Inherited
DEATH domain, DD0.008941Inherited
Pyrin domain, PYD0.0202Inherited
28-residue LRR0.02966Inherited
Caspase catalytic domain0.04558Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
STAT0.000000003234Direct
Transcription factor STAT-4 N-domain0.000000003234Direct
Fibronectin type III0.000001056Direct
4-helical cytokines0.000009763Direct
DEATH domain0.00006517Direct
SH2 domain0.0001211Direct
Toll/Interleukin receptor TIR domain0.0004076Direct
CCCH zinc finger0.005325Inherited
p53-like transcription factors0.007677Inherited
Caspase-like0.03943Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.000000003234Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.000000003234Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.000000003234Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.000005209Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03943Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.03943Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.000000003234Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.000000003234Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)