SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): increased classified tumor incidence

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ + + 3:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
+ + 2:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
+ 1:   increased tumor incidence [MP:0002020] <3>(25|27) (30|10|3)
+ 1:   abnormal classified tumor incidence [MP:0020188] <3>(20|19) (26|7|1)
0:   increased classified tumor incidence [MP:0010273] <19>(20|19) (26|7|1)
- 1:   increased adenoma incidence [MP:0010383] <14>(3|2) (4|1|0)
- 1:   increased fibroma incidence [MP:0003580] <8>(0|0) (0|0|0)
- 1:   increased hemangioma incidence [MP:0002947] <6>(0|0) (0|0|0)
- 1:   increased hamartoma incidence [MP:0010306] <5>(2|1) (2|0|0)
- 1:   increased malignant tumor incidence [MP:0002018] <5>(7|11) (10|6|0)
- 1:   increased leukemia incidence [MP:0002026] <4>(3|4) (3|3|1)
- 1:   increased lymphoma incidence [MP:0012431] <3>(7|9) (7|3|0)
- 1:   increased papilloma incidence [MP:0002014] <3>(1|2) (3|0|0)
- 1:   increased teratoma incidence [MP:0002627] <3>(0|0) (0|0|0)
- 1:   increased myxoma incidence [MP:0003391] <2>(0|0) (0|0|0)
- 1:   increased leiomyoma incidence [MP:0003569] <1>(0|0) (0|0|0)
- 1:   increased lipoma incidence [MP:0010343] <1>(0|0) (0|0|0)
- 1:   increased odontoma incidence [MP:0010353] <1>(0|0) (0|0|0)
- 1:   increased rhabdomyoma incidence [MP:0010391] <1>(0|0) (0|0|0)
- 1:   increased fibroadenoma incidence [MP:0010364](0|0) (0|0|0)
- 1:   increased mesothelioma incidence [MP:0010309](0|0) (0|0|0)
- 1:   increased myeloma incidence [MP:0009440](0|0) (0|0|0)
- 1:   increased myoepithelioma incidence [MP:0012043](0|0) (0|0|0)
- 1:   increased plasmacytoma incidence [MP:0010286](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000002315Direct
Nucleic acid-binding proteins0.00009578Direct
SMAD/FHA domain0.00016Direct
SPOC domain-like0.0004648Direct
DNA-glycosylase0.0004648Direct
DNA repair protein MutS, domain III0.001601Inherited
SAND domain-like0.001601Inherited
Notch domain0.001601Inherited
BRCT domain0.006308Inherited
Putative DNA-binding domain0.006606Inherited
CCCH zinc finger0.03727Inherited
SET domain0.03942Inherited
p53-like transcription factors0.3205Inherited
Cyclin-like0.3205Inherited
DNA/RNA polymerases0.3707Inherited
Intermediate filament protein, coiled coil region0.4335Inherited
Ubiquitin-like0.4582Inherited
ARM repeat0.5305Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6501Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
SMAD MH1 domain0.00000166Direct
SMAD domain0.00000166Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.00000166Direct
DNA polymerase I0.0001462Direct
Notch domain0.001159Inherited
DNA repair protein MutS, domain III0.001159Inherited
Forkhead DNA-binding domain0.001353Inherited
p120GAP domain-like0.002674Inherited
Single strand DNA-binding domain, SSB0.005083Inherited
Histone lysine methyltransferases0.01391Inherited
CCCH zinc finger0.03114Inherited
FHA domain0.04788Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3276Inherited
Intermediate filament protein, coiled coil region0.4291Inherited
DnaQ-like 3'-5' exonuclease0.5305Inherited
Phosphotyrosine-binding domain (PTB)0.5305Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.0000009631Direct
Nucleic acid-binding proteins0.0000461Direct
SMAD/FHA domain0.00007997Direct
DNA-glycosylase0.0002441Direct
SPOC domain-like0.0002441Direct
Chromo domain-like0.0007649Direct
DNA repair protein MutS, domain III0.0008991Direct
SAND domain-like0.0008991Direct
Notch domain0.0008991Direct
BRCT domain0.003833Inherited
Putative DNA-binding domain0.004024Inherited
CCCH zinc finger0.02574Inherited
SET domain0.0273Inherited
Cysteine-rich domain0.2764Inherited
p53-like transcription factors0.2764Inherited
Cyclin-like0.2764Inherited
DNA/RNA polymerases0.3248Inherited
Snake toxin-like0.3248Inherited
Ribonuclease H-like0.3816Inherited
Intermediate filament protein, coiled coil region0.3864Inherited
Ubiquitin-like0.4104Inherited
ARM repeat0.4834Inherited
4-helical cytokines0.4927Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6066Inherited
Leucine zipper domain0.6735Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0002441Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0008991Direct
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.006529Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.006694Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.006694Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.05177Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.03257Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)