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Mammalian Phenotype (MP): increased organ/body region tumor incidence

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ + + 3:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
+ + 2:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
+ 1:   increased tumor incidence [MP:0002020] <3>(25|27) (30|10|3)
+ 1:   abnormal organ/body region tumor incidence [MP:0013152] <2>(21|24) (24|8|3)
0:   increased organ/body region tumor incidence [MP:0010274] <14>(21|24) (24|8|3)
- 1:   increased gland tumor incidence [MP:0010288] <15>(6|9) (7|2|0)
- 1:   increased nervous system tumor incidence [MP:0010281] <13>(1|0) (1|0|0)
- 1:   increased hemolymphoid system tumor incidence [MP:0010296] <7>(10|10) (10|4|1)
- 1:   increased urinary system tumor incidence [MP:0010289] <5>(2|1) (2|0|0)
- 1:   increased muscle tumor incidence [MP:0010290] <4>(0|0) (0|0|0)
- 1:   increased reproductive system tumor incidence [MP:0010287] <4>(3|4) (3|0|0)
- 1:   increased alimentary system tumor incidence [MP:0010292] <3>(3|5) (3|2|0)
- 1:   increased cardiovascular system tumor incidence [MP:0010291] <3>(0|0) (0|0|0)
- 1:   increased integument system tumor incidence [MP:0010293] <3>(4|7) (7|5|2)
- 1:   increased skeletal tumor incidence [MP:0010280] <3>(0|0) (0|0|0)
- 1:   increased eye tumor incidence [MP:0010295] <2>(1|1) (1|0|0)
- 1:   increased hepatobiliary system tumor incidence [MP:0010297] <2>(1|3) (1|1|0)
- 1:   increased respiratory system tumor incidence [MP:0010298] <1>(2|3) (2|2|0)
- 1:   increased reticular tumor incidence [MP:0020199] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000003438Direct
Nucleic acid-binding proteins0.0001639Direct
SMAD/FHA domain0.0002744Direct
RING/U-box0.0004858Direct
SPOC domain-like0.0005745Direct
DNA-glycosylase0.0005745Direct
Cyclin-like0.0009346Direct
DNA repair protein MutS, domain III0.001948Inherited
SAND domain-like0.001948Inherited
Notch domain0.001948Inherited
Putative DNA-binding domain0.007921Inherited
BRCT domain0.008388Inherited
CCCH zinc finger0.0435Inherited
SET domain0.05099Inherited
ARM repeat0.1031Inherited
Protein kinase-like (PK-like)0.1223Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.277Inherited
p53-like transcription factors0.4289Inherited
Intermediate filament protein, coiled coil region0.4736Inherited
4-helical cytokines0.6753Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
SMAD MH1 domain0.00000249Direct
SMAD domain0.00000249Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.00000249Direct
DNA polymerase I0.0001924Direct
Pointed domain0.0005226Direct
L domain0.0005226Direct
Notch domain0.001429Inherited
DNA repair protein MutS, domain III0.001429Inherited
p120GAP domain-like0.003416Inherited
Single strand DNA-binding domain, SSB0.006186Inherited
Short-chain cytokines0.01062Inherited
Histone lysine methyltransferases0.01782Inherited
CCCH zinc finger0.03692Inherited
FHA domain0.05769Inherited
Protein kinases, catalytic subunit0.08385Inherited
Phosphotyrosine-binding domain (PTB)0.2718Inherited
ABC transporter ATPase domain-like0.2792Inherited
Intermediate filament protein, coiled coil region0.4716Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.491Inherited
DnaQ-like 3'-5' exonuclease0.6249Inherited
Forkhead DNA-binding domain0.6835Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.00000146Direct
Nucleic acid-binding proteins0.00008206Direct
SMAD/FHA domain0.0001405Direct
RING/U-box0.000256Direct
DNA-glycosylase0.0003044Direct
SPOC domain-like0.0003044Direct
Cyclin-like0.0005078Direct
DNA repair protein MutS, domain III0.001107Inherited
SAND domain-like0.001107Inherited
Notch domain0.001107Inherited
Putative DNA-binding domain0.004869Inherited
BRCT domain0.005178Inherited
CCCH zinc finger0.03036Inherited
SET domain0.03604Inherited
ARM repeat0.07807Inherited
Protein kinase-like (PK-like)0.0945Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2351Inherited
p53-like transcription factors0.3819Inherited
Intermediate filament protein, coiled coil region0.4259Inherited
DNA/RNA polymerases0.4312Inherited
Cysteine-rich domain0.4312Inherited
Leucine zipper domain0.4312Inherited
4-helical cytokines0.6332Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0003044Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0003848Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0003848Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001107Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00808Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.008176Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.06236Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0003044Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0003848Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.03844Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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