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Mammalian Phenotype (MP): preweaning lethality

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   mortality/aging [MP:0010768] <4>(83|115) (89|67|50)
+ 1:   abnormal survival [MP:0010769] <10>(60|91) (67|55|39)
0:   preweaning lethality [MP:0010770] <4>(48|79) (55|45|38)
- 1:   lethality during fetal growth through weaning [MP:0010832] <5>(19|37) (23|28|22)
- 1:   prenatal lethality [MP:0002080] <5>(27|49) (30|23|16)
- 1:   preweaning lethality, complete penetrance [MP:0011100](2|2) (2|0|0)
- 1:   preweaning lethality, incomplete penetrance [MP:0011110](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Mib/herc2 domain-like0Direct
Roadblock/LC7 domain0Direct
Nucleoporin domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Tricorn protease domain 20Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
SWIB/MDM2 domain0Direct
SRF-like0Direct
Uracil-DNA glycosylase-like0Direct
2Fe-2S ferredoxin-like0Direct
Protein prenylyltransferase0Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
DNA clamp0Direct
E2F-DP heterodimerization region0Direct
Lamin A/C globular tail domain0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
p53 tetramerization domain0Direct
SMAD MH1 domain0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
Mob1/phocein0Direct
Ribonuclease PH domain 2-like0Direct
Zinc beta-ribbon0Direct
A heparin-binding domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
GroEL-intermediate domain like0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Nucleic acid-binding proteins0.000002894Direct
Homeodomain-like0.0007596Direct
SCOP hierarchy in SUPERFAMILY0.01305Inherited
GAT-like domain0.0374Inherited
TB module/8-cys domain0.06346Inherited
GroEL apical domain-like0.06688Inherited
Growth factor receptor domain0.09875Inherited
HCP-like0.1031Inherited
Terpenoid synthases0.1176Inherited
"Winged helix" DNA-binding domain0.1225Inherited
ARM repeat0.1527Inherited
BRCT domain0.255Inherited
Flavoproteins0.2753Inherited
L27 domain0.2864Inherited
p53-like transcription factors0.3204Inherited
HLH, helix-loop-helix DNA-binding domain0.3529Inherited
dsRNA-binding domain-like0.3536Inherited
Protein kinase-like (PK-like)0.419Inherited
EGF/Laminin0.5637Inherited
ADC-like0.7382Inherited
Cullin homology domain0.8866Inherited
Subtilisin-like0.8866Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
A heparin-binding domain0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
p53 DNA-binding domain-like0Direct
Neurotrophin0Direct
Mib/herc2 domain0Direct
U-box0Direct
SMAD MH1 domain0Direct
SWIB/MDM2 domain0Direct
Retinoblastoma tumor suppressor domains0Direct
SMAD4-binding domain of oncoprotein Ski0Direct
RUNT domain0Direct
Pointed domain0Direct
DNA ligase0Direct
Chromo barrel domain0Direct
L domain0Direct
gamma-adaptin C-terminal appendage domain-like0Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
SMAD domain0Direct
SRF-like0Direct
Cell cycle transcription factor e2f-dp0Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
E2F dimerization segment0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
L-aspartase/fumarase0Direct
Adenosine/AMP deaminase0Direct
ATP-dependent DNA ligase catalytic domain0Direct
p53 tetramerization domain0Direct
Paired domain0Direct
Mob1/phocein0Direct
SIAH, seven in absentia homolog0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
Ribonuclease PH domain 1-like0Direct
Fumble-like0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Lamin A/C globular tail domain0Direct
Ribonuclease PH domain 2-like0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Roadblock/LC7 domain0Direct
Histone lysine methyltransferases0.00001674Direct
T-box0.000248Direct
Homeodomain0.0007645Direct
ZZ domain0.008344Inherited
Erythroid transcription factor GATA-10.008344Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.008344Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.01604Inherited
Growth factor receptor domain0.01679Inherited
RecA protein-like (ATPase-domain)0.02657Inherited
Inhibitor of apoptosis (IAP) repeat0.02912Inherited
Tandem AAA-ATPase domain0.02927Inherited
TB module/8-cys domain0.05181Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.05392Inherited
NADPH-cytochrome p450 reductase-like0.05392Inherited
Extracellular domain of cell surface receptors0.06983Inherited
GAT domain0.09854Inherited
HMA, heavy metal-associated domain0.09854Inherited
C5 cytosine-specific DNA methylase, DCM0.09854Inherited
Laminin G-like module0.1344Inherited
DNA polymerase I0.1416Inherited
Proprotein convertase P-domain0.1416Inherited
Prohormone convertase 1 pro-domain0.1416Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.1676Inherited
ets domain0.1774Inherited
Forkhead DNA-binding domain0.2062Inherited
Adenain-like0.227Inherited
L27 domain0.2635Inherited
Linker histone H1/H50.2635Inherited
HLH, helix-loop-helix DNA-binding domain0.2977Inherited
N-acetyl transferase, NAT0.4055Inherited
Protein kinases, catalytic subunit0.4876Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.5576Inherited
Subtilases0.5839Inherited
Blood coagulation inhibitor (disintegrin)0.5893Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.59Inherited
SCF ubiquitin ligase complex WHB domain0.64Inherited
Extended AAA-ATPase domain0.8273Inherited
Cullin homology domain0.8611Inherited
Armadillo repeat0.9112Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
GroEL-intermediate domain like0Direct
Tricorn protease domain 20Direct
2Fe-2S ferredoxin-like0Direct
Lamin A/C globular tail domain0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
DNA clamp0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Nucleoporin domain0Direct
Mib/herc2 domain-like0Direct
Roadblock/LC7 domain0Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
A heparin-binding domain0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Uracil-DNA glycosylase-like0Direct
Zinc beta-ribbon0Direct
Ribonuclease PH domain 2-like0Direct
p53 tetramerization domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
E2F-DP heterodimerization region0Direct
SWIB/MDM2 domain0Direct
SRF-like0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
Protein prenylyltransferase0Direct
Mob1/phocein0Direct
SMAD MH1 domain0Direct
Nucleic acid-binding proteins0.000001218Direct
Homeodomain-like0.0004083Direct
HMG-box0.0007298Direct
GAT-like domain0.02582Inherited
TB module/8-cys domain0.04598Inherited
GroEL apical domain-like0.04865Inherited
Growth factor receptor domain0.07446Inherited
HCP-like0.07805Inherited
Inhibitor of apoptosis (IAP) repeat0.07805Inherited
Orange domain-like0.07805Inherited
HMA, heavy metal-associated domain0.09053Inherited
Terpenoid synthases0.09053Inherited
"Winged helix" DNA-binding domain0.09468Inherited
ARM repeat0.1211Inherited
BRCT domain0.2143Inherited
Flavoproteins0.2335Inherited
Acyl-CoA N-acyltransferases (Nat)0.2345Inherited
L27 domain0.244Inherited
p53-like transcription factors0.2763Inherited
HLH, helix-loop-helix DNA-binding domain0.3075Inherited
dsRNA-binding domain-like0.3081Inherited
Protein kinase-like (PK-like)0.3721Inherited
EGF/Laminin0.5172Inherited
Blood coagulation inhibitor (disintegrin)0.5577Inherited
Riboflavin synthase domain-like0.6585Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.6585Inherited
ADC-like0.6995Inherited
Cullin homology domain0.8587Inherited
Subtilisin-like0.8587Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    64268,103657
  • 64268 - PX domain
  • 103657 - BAR/IMD domain-like
  • 0Direct
    82199,57903
  • 82199 - SET domain
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    46955,63763
  • 46955 - Putative DNA-binding domain
  • 63763 - SAND domain-like
  • 0Direct
    49562,51045
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 51045 - WW domain
  • 0Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    56491,89811
  • 56491 - A heparin-binding domain
  • 89811 - Amyloid beta a4 protein copper binding domain (domain 2)
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    63748,82199
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    57903,63748
  • 57903 - FYVE/PHD zinc finger
  • 63748 - Tudor/PWWP/MBT
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.007029Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.01347Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.01347Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.02582Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.02582Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.02582Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.02582Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.07805Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.09053Inherited
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.1304Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1335Inherited
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1536Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.2124Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.2335Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2335Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.3376Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.5322Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.5577Inherited
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.6391Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.6391Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.6995Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,63825
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    57903,63748,82199
  • 57903 - FYVE/PHD zinc finger
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 0Direct
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    49265,48726,49265
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    57424,57196,57196
  • 57424 - LDL receptor-like module
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0Direct
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    57196,57196,49899
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    63748,82199,57903
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    75399,75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    63748,63748,63748
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 0Direct
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0002193Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0009022Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.02582Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.02582Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.04865Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04865Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.07805Inherited
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.1304Inherited
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1536Inherited
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1536Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.2124Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.3697Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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