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Mammalian Phenotype (MP): abnormal hematopoietic cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + 2:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ 1:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
0:   abnormal hematopoietic cell number [MP:0011180] <7>(34|57) (43|29|13)
- 1:   abnormal leukocyte cell number [MP:0000217] <8>(29|49) (37|25|12)
- 1:   abnormal granulocyte number [MP:0020201] <6>(3|7) (5|6|2)
- 1:   abnormal myeloid cell number [MP:0013661] <6>(4|7) (4|2|0)
- 1:   decreased hematopoietic cell number [MP:0011182] <5>(21|34) (27|21|11)
- 1:   increased hematopoietic cell number [MP:0011181] <4>(12|26) (19|11|7)
- 1:   abnormal macrophage cell number [MP:0020202] <2>(5|7) (5|1|0)
- 1:   abnormal platelet cell number [MP:0011898] <2>(1|2) (1|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
L30e-like0.002521Inherited
DNA polymerase beta, N-terminal domain-like0.006129Inherited
Flavoproteins0.007249Inherited
Toll/Interleukin receptor TIR domain0.01356Inherited
AraD/HMP-PK domain-like0.0186Inherited
Triple coiled coil domain of C-type lectins0.0186Inherited
DEATH domain0.02001Inherited
Ran binding protein zinc finger-like0.0225Inherited
p53-like transcription factors0.03036Inherited
Bcl-2 inhibitors of programmed cell death0.03268Inherited
SH2 domain0.03436Inherited
E2F-DP heterodimerization region0.04155Inherited
WWE domain0.04155Inherited
TNF receptor-like0.07051Inherited
4-helical cytokines0.1669Inherited
Integrin alpha N-terminal domain0.1848Inherited
Integrin domains0.2497Inherited
TIMP-like0.2522Inherited
MHC antigen-recognition domain0.3185Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3447Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3785Inherited
Riboflavin synthase domain-like0.3785Inherited
Calponin-homology domain, CH-domain0.3969Inherited
DBL homology domain (DH-domain)0.4706Inherited
Cysteine-rich domain0.519Inherited
A DNA-binding domain in eukaryotic transcription factors0.6222Inherited
Nuclear receptor ligand-binding domain0.631Inherited
Terpenoid cyclases/Protein prenyltransferases0.7511Inherited
Cyclin-like0.7617Inherited
SMAD/FHA domain0.7719Inherited
Nucleic acid-binding proteins0.9121Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
BAFF receptor-like0Direct
Proteasome subunits0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
DNA polymerase beta-like0Direct
Short-chain cytokines0.0000001151Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0001722Direct
Pyrin domain, PYD0.0003706Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00131Inherited
ets domain0.003346Inherited
Notch domain0.004261Inherited
DNA polymerase beta, N-terminal domain-like0.004261Inherited
Interleukin-1 (IL-1)0.004261Inherited
Pointed domain0.005141Inherited
Erythroid transcription factor GATA-10.01285Inherited
Triple coiled coil domain of C-type lectins0.01358Inherited
Tissue inhibitor of metalloproteinases, TIMP0.01358Inherited
AraD-like aldolase/epimerase0.01358Inherited
Cytochrome p450 reductase N-terminal domain-like0.01358Inherited
E2F dimerization segment0.01461Inherited
WWE domain0.01461Inherited
Ran binding protein zinc finger-like0.01742Inherited
Toll/Interleukin receptor TIR domain0.02023Inherited
Bcl-2 inhibitors of programmed cell death0.02506Inherited
Interferon regulatory factor0.02506Inherited
SH2 domain0.02527Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.03933Inherited
NADPH-cytochrome p450 reductase-like0.03933Inherited
Nuclear receptor coactivator interlocking domain0.03933Inherited
V set domains (antibody variable domain-like)0.07282Inherited
Cell cycle transcription factor e2f-dp0.08923Inherited
TNF receptor-like0.09221Inherited
DEATH domain, DD0.09221Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1225Inherited
MATH domain0.1694Inherited
C1 set domains (antibody constant domain-like)0.1885Inherited
Integrin domains0.2162Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2179Inherited
MHC antigen-recognition domain0.2817Inherited
CCCH zinc finger0.3637Inherited
Calponin-homology domain, CH-domain0.3794Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.4314Inherited
DBL homology domain (DH-domain)0.4321Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4771Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.487Inherited
Noncollagenous (NC1) domain of collagen IV0.5116Inherited
Pleckstrin-homology domain (PH domain)0.5286Inherited
SH3-domain0.5432Inherited
Cyclin0.5853Inherited
A DNA-binding domain in eukaryotic transcription factors0.5853Inherited
Nuclear receptor ligand-binding domain0.5966Inherited
Nuclear receptor0.5966Inherited
PLC-like (P variant)0.7524Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.9292Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
L30e-like0.00145Inherited
DNA polymerase beta, N-terminal domain-like0.003715Inherited
Notch domain0.003715Inherited
Flavoproteins0.004447Inherited
Toll/Interleukin receptor TIR domain0.008651Inherited
AraD/HMP-PK domain-like0.01212Inherited
Triple coiled coil domain of C-type lectins0.01212Inherited
DEATH domain0.01312Inherited
Ran binding protein zinc finger-like0.0149Inherited
NAD kinase/diacylglycerol kinase-like0.01682Inherited
p53-like transcription factors0.02067Inherited
Bcl-2 inhibitors of programmed cell death0.02235Inherited
SH2 domain0.02359Inherited
WWE domain0.02894Inherited
E2F-DP heterodimerization region0.02894Inherited
Nuclear receptor coactivator interlocking domain0.03591Inherited
TNF receptor-like0.05157Inherited
4-helical cytokines0.1334Inherited
C-type lectin-like0.1423Inherited
Integrin alpha N-terminal domain0.1496Inherited
Integrin domains0.2094Inherited
Protein kinase-like (PK-like)0.2107Inherited
TIMP-like0.2118Inherited
MHC antigen-recognition domain0.2744Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2993Inherited
Riboflavin synthase domain-like0.3325Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3325Inherited
Calponin-homology domain, CH-domain0.3503Inherited
CCCH zinc finger0.3554Inherited
DBL homology domain (DH-domain)0.4228Inherited
Cysteine-rich domain0.4716Inherited
SH3-domain0.5315Inherited
A DNA-binding domain in eukaryotic transcription factors0.5772Inherited
Nuclear receptor ligand-binding domain0.5866Inherited
beta-beta-alpha zinc fingers0.5903Inherited
Terpenoid cyclases/Protein prenyltransferases0.713Inherited
Cyclin-like0.724Inherited
SMAD/FHA domain0.7348Inherited
Acyl-CoA N-acyltransferases (Nat)0.7628Inherited
Nucleic acid-binding proteins0.8865Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    49562,51045
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 51045 - WW domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0001384Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.001087Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00145Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.004142Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.01212Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.02894Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.08879Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.119Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1314Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1496Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1632Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.178Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.178Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.2094Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.2993Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3128Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.4228Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.4233Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.4233Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.4233Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.4233Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.4389Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.5772Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.002809Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.07377Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.111Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.178Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.4233Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.4233Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.5034Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5034Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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