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Mammalian Phenotype (MP): abnormal natural killer cell mediated cytotoxicity

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   mammalian phenotype [MP:0000001] <29>
+ + + + + + 6:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + + 5:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
+ + + + 4:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
+ + + + 4:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
+ + + + 4:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
+ + + + 4:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
+ + + 3:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + + 3:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
+ + 2:   abnormal innate immunity [MP:0002419] <5>(17|15) (18|9|5)
+ + 2:   abnormal lymphocyte physiology [MP:0003945] <4>(21|31) (23|22|13)
+ 1:   abnormal NK cell physiology [MP:0010766] <2>(7|5) (7|5|3)
0:   abnormal natural killer cell mediated cytotoxicity [MP:0011719] <3>(7|5) (7|3|2)
- 1:   abnormal NK cell degranulation [MP:0008790] <2>(0|0) (0|0|0)
- 1:   impaired natural killer cell mediated cytotoxicity [MP:0005070](6|4) (6|3|2)
- 1:   increased natural killer cell mediated cytotoxicity [MP:0003080](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
4-helical cytokines0.0002795Direct
MHC antigen-recognition domain0.0003108Direct
p53-like transcription factors0.2424Inherited
STAT0.3236Inherited
Transcription factor STAT-4 N-domain0.3236Inherited
SH2 domain0.3572Inherited
Toll/Interleukin receptor TIR domain0.7555Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
MHC antigen-recognition domain0.0002048Direct
STAT DNA-binding domain0.2857Inherited
STAT0.2857Inherited
Transcription factor STAT-4 N-domain0.2857Inherited
SH2 domain0.3206Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
4-helical cytokines0.0001434Direct
MHC antigen-recognition domain0.0001603Direct
p53-like transcription factors0.2028Inherited
STAT0.2793Inherited
Transcription factor STAT-4 N-domain0.2793Inherited
SH2 domain0.3117Inherited
Toll/Interleukin receptor TIR domain0.7176Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2793Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.2793Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2793Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2793Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2793Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)