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Mammalian Phenotype (MP): abnormal sterol level

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + + 3:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ + 2:   abnormal lipid homeostasis [MP:0002118] <9>(25|29) (29|17|10)
+ 1:   abnormal lipid level [MP:0001547] <16>(24|28) (26|16|10)
0:   abnormal sterol level [MP:0012224] <5>(11|13) (14|10|8)
- 1:   abnormal cholesterol level [MP:0003947] <5>(11|12) (13|10|8)
- 1:   abnormal phytosterol level [MP:0010076] <3>(0|1) (1|0|0)
- 1:   decreased sterol level [MP:0012225] <3>(2|2) (3|1|1)
- 1:   increased sterol level [MP:0012226] <3>(5|7) (6|5|6)
- 1:   abnormal vitamin D level [MP:0011228] <2>(0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Apolipoprotein A-I0.00003661Direct
YWTD domain0.0002374Direct
Multidrug efflux transporter AcrB transmembrane domain0.0009159Direct
Serum albumin-like0.001318Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1406Inherited
Riboflavin synthase domain-like0.1406Inherited
Flavoproteins0.1406Inherited
Bet v1-like0.1605Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.1605Inherited
alpha/beta-Hydrolases0.2017Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Apolipoprotein A-I0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.00002114Direct
NADPH-cytochrome p450 reductase-like0.00002114Direct
YWTD domain0.0001497Direct
Phoshoinositide 3-kinase (PI3K) helical domain0.0002697Direct
Serum albumin-like0.0008434Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0008442Direct
Pancreatic lipase, N-terminal domain0.1166Inherited
ABC transporter ATPase domain-like0.3319Inherited
Sir2 family of transcriptional regulators0.3744Inherited
Fatty acid binding protein-like0.434Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Apolipoprotein A-I0.00001692Direct
YWTD domain0.0001205Direct
Multidrug efflux transporter AcrB transmembrane domain0.0004976Direct
Serum albumin-like0.0007324Direct
Riboflavin synthase domain-like0.1104Inherited
Flavoproteins0.1104Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1104Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.1279Inherited
Bet v1-like0.1279Inherited
alpha/beta-Hydrolases0.1648Inherited
Lipocalins0.3204Inherited
DHS-like NAD/FAD-binding domain0.3626Inherited
P-loop containing nucleoside triphosphate hydrolases0.5069Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.00001692Direct
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.00003163Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.00006463Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.000227Direct
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.000227Direct
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.000227Direct
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.0007324Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.0009327Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.2548Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.00001777Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.00008004Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.00008004Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.00008004Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.000227Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.001734Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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