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Mammalian Phenotype (MP): abnormal blood cell physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ 1:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
0:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
- 1:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
- 1:   abnormal erythrocyte physiology [MP:0003656] <4>(1|1) (1|1|0)
- 1:   abnormal platelet physiology [MP:0005464] <2>(5|8) (6|5|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DEATH domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.0000001436Direct
p53-like transcription factors0.000002173Direct
C-type lectin-like0.00001649Direct
Caspase-like0.0000524Direct
TNF-like0.0002744Direct
Interleukin 8-like chemokines0.0002859Direct
Integrin domains0.0004505Direct
Cysteine-rich domain0.001037Inherited
Inhibitor of apoptosis (IAP) repeat0.002751Inherited
Integrin alpha N-terminal domain0.009194Inherited
Integrin beta tail domain0.02028Inherited
DBL homology domain (DH-domain)0.02848Inherited
Transducin (alpha subunit), insertion domain0.04921Inherited
PH domain-like0.07142Inherited
Family A G protein-coupled receptor-like0.07745Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.08439Inherited
WWE domain0.08785Inherited
Flavoproteins0.08785Inherited
PLC-like phosphodiesterases0.09712Inherited
E set domains0.09997Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1112Inherited
L30e-like0.1258Inherited
SH3-domain0.1298Inherited
Complement control module/SCR domain0.1805Inherited
4-helical cytokines0.4782Inherited
EGF/Laminin0.4902Inherited
Toll/Interleukin receptor TIR domain0.4962Inherited
SH2 domain0.559Inherited
vWA-like0.6007Inherited
MHC antigen-recognition domain0.6007Inherited
SMAD/FHA domain0.6735Inherited
Bcl-2 inhibitors of programmed cell death0.7839Inherited
A DNA-binding domain in eukaryotic transcription factors0.7839Inherited
L domain-like0.7843Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Cysteine rich domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Proteasome subunits0Direct
STAT DNA-binding domain0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
V set domains (antibody variable domain-like)0.000000006026Direct
C1 set domains (antibody constant domain-like)0.0000001121Direct
TNF receptor-like0.0000001205Direct
C-type lectin domain0.000000285Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000001128Direct
Caspase recruitment domain, CARD0.00002434Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00003094Direct
DEATH domain, DD0.00008457Direct
Pyrin domain, PYD0.0001086Direct
Caspase catalytic domain0.0001354Direct
Pleckstrin-homology domain (PH domain)0.0001945Direct
Interleukin 8-like chemokines0.0002266Direct
TNF-like0.000228Direct
Integrin domains0.0003549Direct
Inhibitor of apoptosis (IAP) repeat0.0004615Direct
PLC-like (P variant)0.000535Direct
28-residue LRR0.001157Inherited
Interferon regulatory factor0.001632Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.001976Inherited
Cytochrome p450 reductase N-terminal domain-like0.007226Inherited
Integrin alpha N-terminal domain0.008117Inherited
Integrin beta tail domain0.01581Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.01581Inherited
NADPH-cytochrome p450 reductase-like0.02197Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02197Inherited
Interleukin 17F, IL-17F0.02197Inherited
DBL homology domain (DH-domain)0.02583Inherited
Integrin beta EGF-like domains0.02921Inherited
Transducin (alpha subunit), insertion domain0.04144Inherited
WWE domain0.04435Inherited
Mammalian PLC0.04542Inherited
Rhodopsin-like0.07572Inherited
Integrin A (or I) domain0.09673Inherited
SH3-domain0.1029Inherited
Complement control module/SCR domain0.1706Inherited
I set domains0.2615Inherited
EGF-type module0.4679Inherited
FHA domain0.4729Inherited
Toll/Interleukin receptor TIR domain0.4734Inherited
SH2 domain0.5155Inherited
MHC antigen-recognition domain0.5593Inherited
Short-chain cytokines0.6354Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.6911Inherited
A DNA-binding domain in eukaryotic transcription factors0.7518Inherited
Bcl-2 inhibitors of programmed cell death0.7518Inherited
G proteins0.8553Inherited
ets domain0.9483Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.00000005689Direct
p53-like transcription factors0.0000009021Direct
C-type lectin-like0.000007342Direct
Caspase-like0.00002462Direct
TNF-like0.0001405Direct
Interleukin 8-like chemokines0.0001467Direct
Integrin domains0.0002366Direct
Cysteine-rich domain0.0005678Direct
Inhibitor of apoptosis (IAP) repeat0.001586Inherited
Integrin alpha N-terminal domain0.005705Inherited
Integrin beta tail domain0.01332Inherited
DBL homology domain (DH-domain)0.01926Inherited
RNI-like0.03237Inherited
Transducin (alpha subunit), insertion domain0.03472Inherited
PH domain-like0.05232Inherited
Family A G protein-coupled receptor-like0.05701Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.06263Inherited
WWE domain0.0655Inherited
Flavoproteins0.0655Inherited
PLC-like phosphodiesterases0.07309Inherited
E set domains0.07543Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.08513Inherited
L30e-like0.09755Inherited
SH3-domain0.101Inherited
Complement control module/SCR domain0.1457Inherited
4-helical cytokines0.4305Inherited
EGF/Laminin0.4425Inherited
Toll/Interleukin receptor TIR domain0.4485Inherited
SH2 domain0.5124Inherited
vWA-like0.5551Inherited
MHC antigen-recognition domain0.5551Inherited
SMAD/FHA domain0.6314Inherited
Bcl-2 inhibitors of programmed cell death0.7481Inherited
A DNA-binding domain in eukaryotic transcription factors0.7481Inherited
L domain-like0.7485Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000000694Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000001206Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00001559Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0003643Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0003643Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0004245Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.001277Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.001586Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.00258Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.00258Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.004275Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.004275Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.006163Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.008965Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.008965Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.01332Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01332Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01909Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02456Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.02594Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.02594Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.02759Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.07769Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1384Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2936Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.51Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.7481Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.7809Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.8143Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.8506Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.001519Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.001519Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.001586Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.00258Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.004091Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.004275Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01332Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01909Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.03472Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.6051Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.8506Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.8506Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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