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Mammalian Phenotype (MP): increased cell death

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   cellular phenotype [MP:0005384] <6>(95|116) (103|56|31)
+ + 2:   abnormal cell physiology [MP:0005621] <24>(77|96) (84|46|25)
+ 1:   abnormal cell death [MP:0000313] <5>(29|41) (33|15|5)
0:   increased cell death [MP:0012556] <1>(16|23) (18|7|3)
- 1:   increased apoptosis [MP:0006042] <34>(16|23) (18|7|3)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SRF-like0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Ran binding protein zinc finger-like0.0001151Direct
STAT0.0001375Direct
Transcription factor STAT-4 N-domain0.0001375Direct
Cullin repeat-like0.0008495Direct
Flavoproteins0.002122Inherited
Arginase/deacetylase0.08558Inherited
BRCT domain0.09107Inherited
SH2 domain0.1543Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.182Inherited
Riboflavin synthase domain-like0.182Inherited
Rhodanese/Cell cycle control phosphatase0.2862Inherited
Leucine zipper domain0.7256Inherited
Fibronectin type III0.8114Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Cullin repeat0Direct
Retinoblastoma tumor suppressor domains0Direct
SRF-like0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Ran binding protein zinc finger-like0.0000831Direct
STAT DNA-binding domain0.000092Direct
STAT0.000092Direct
Transcription factor STAT-4 N-domain0.000092Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0001367Direct
SCF ubiquitin ligase complex WHB domain0.0001367Direct
NADPH-cytochrome p450 reductase-like0.0001367Direct
Histone deacetylase, HDAC0.04342Inherited
SH2 domain0.1379Inherited
Extracellular domain of cell surface receptors0.259Inherited
ets domain0.259Inherited
I set domains0.294Inherited
WW domain0.3453Inherited
Cell cycle control phosphatase, catalytic domain0.3453Inherited
Leucine zipper domain0.7094Inherited
Fibronectin type III0.8252Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
SRF-like0Direct
Ran binding protein zinc finger-like0.00005635Direct
STAT0.00006821Direct
Transcription factor STAT-4 N-domain0.00006821Direct
Cullin repeat-like0.0004597Direct
Flavoproteins0.00121Inherited
Arginase/deacetylase0.06356Inherited
BRCT domain0.0681Inherited
SH2 domain0.1225Inherited
Riboflavin synthase domain-like0.147Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.147Inherited
Rhodanese/Cell cycle control phosphatase0.2439Inherited
WW domain0.3281Inherited
Leucine zipper domain0.6862Inherited
Fibronectin type III0.7772Inherited
Immunoglobulin0.8375Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00006821Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.00006821Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00006821Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0001062Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6994Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00006821Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00006821Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)