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Mammalian Phenotype (MP): abnormal endocrine gland morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   endocrine/exocrine gland phenotype [MP:0005379] <2>(51|81) (55|36|12)
+ 1:   abnormal gland morphology [MP:0002163] <8>(44|71) (50|31|11)
0:   abnormal endocrine gland morphology [MP:0013560] <7>(16|29) (21|19|4)
- 1:   abnormal thymus morphology [MP:0000703] <14>(10|16) (12|10|2)
- 1:   abnormal adrenal gland morphology [MP:0000639] <11>(1|1) (2|1|0)
- 1:   abnormal thyroid gland morphology [MP:0000681] <10>(1|3) (1|0|0)
- 1:   abnormal parathyroid gland morphology [MP:0000678] <8>(0|0) (0|1|0)
- 1:   abnormal neuroendocrine gland morphology [MP:0000631] <3>(3|3) (4|1|0)
- 1:   abnormal ultimobranchial body morphology [MP:0003955] <2>(1|1) (1|0|0)
- 1:   abnormal endocrine pancreas morphology [MP:0009165] <1>(4|8) (5|7|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SH2 domain0.000002887Direct
STAT0.000007174Direct
Transcription factor STAT-4 N-domain0.000007174Direct
Bcl-2 inhibitors of programmed cell death0.0001378Direct
Cysteine-rich domain0.004688Inherited
p53-like transcription factors0.008114Inherited
TNF receptor-like0.01856Inherited
Nuclear receptor ligand-binding domain0.01904Inherited
Homeodomain-like0.02933Inherited
CCCH zinc finger0.03456Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.07704Inherited
TNF-like0.1137Inherited
E set domains0.1341Inherited
beta-beta-alpha zinc fingers0.3631Inherited
Insulin-like0.475Inherited
HLH, helix-loop-helix DNA-binding domain0.527Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
SH2 domain0.000002392Direct
STAT DNA-binding domain0.000005082Direct
STAT0.000005082Direct
Transcription factor STAT-4 N-domain0.000005082Direct
Bcl-2 inhibitors of programmed cell death0.0001025Direct
Transducin (alpha subunit), insertion domain0.000825Direct
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.002326Inherited
DEATH domain, DD0.002495Inherited
Forkhead DNA-binding domain0.00761Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.008114Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.008114Inherited
Linker histone H1/H50.009073Inherited
Nuclear receptor0.01298Inherited
TNF receptor-like0.01426Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.01426Inherited
Paired domain0.01426Inherited
Nuclear receptor ligand-binding domain0.01615Inherited
CCCH zinc finger0.02931Inherited
Phosphotyrosine-binding domain (PTB)0.03103Inherited
Homeodomain0.06678Inherited
TNF-like0.1099Inherited
Papain-like0.1265Inherited
E2F dimerization segment0.1863Inherited
Cytochrome P4500.4024Inherited
Insulin-like0.4512Inherited
HLH, helix-loop-helix DNA-binding domain0.5241Inherited
Pointed domain0.5788Inherited
ets domain0.6665Inherited
Rhodopsin-like0.9734Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SH2 domain0.000001215Direct
STAT0.000003098Direct
Transcription factor STAT-4 N-domain0.000003098Direct
Bcl-2 inhibitors of programmed cell death0.00006837Direct
Transducin (alpha subunit), insertion domain0.0005599Direct
Cysteine-rich domain0.002794Inherited
p53-like transcription factors0.004998Inherited
TNF receptor-like0.0121Inherited
Nuclear receptor ligand-binding domain0.01243Inherited
Homeodomain-like0.01991Inherited
Protein kinase-like (PK-like)0.01991Inherited
CCCH zinc finger0.02374Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.05668Inherited
"Winged helix" DNA-binding domain0.06185Inherited
TNF-like0.08718Inherited
E set domains0.1048Inherited
beta-beta-alpha zinc fingers0.3174Inherited
Cytochrome P4500.3535Inherited
Insulin-like0.4273Inherited
HLH, helix-loop-helix DNA-binding domain0.4797Inherited
Family A G protein-coupled receptor-like0.8948Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.000003098Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.000003098Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.000003098Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00001952Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003227Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0007522Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0008854Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.001084Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.008966Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.008966Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00933Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.009526Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0121Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1105Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.2716Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.362Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4586Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.000003098Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.000003098Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0121Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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