SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal hematopoietic cell morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ 1:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
0:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
- 1:   abnormal myeloid cell morphology [MP:0013658] <8>(19|41) (26|23|8)
- 1:   abnormal hematopoietic cell number [MP:0011180] <7>(34|57) (43|29|13)
- 1:   abnormal blood cell morphology [MP:0013657] <4>(31|49) (37|35|14)
- 1:   abnormal hematopoietic stem cell morphology [MP:0004808] <4>(2|3) (2|3|0)
- 1:   abnormal leukocyte morphology [MP:0008246] <4>(36|62) (47|29|15)
- 1:   abnormal bone marrow hematopoietic cell morphology [MP:0013660] <2>(1|3) (2|3|0)
- 1:   abnormal common lymphocyte progenitor cell morphology [MP:0008249] <2>(0|1) (0|0|0)
- 1:   abnormal common myeloid progenitor cell morphology [MP:0006410] <2>(1|1) (1|2|0)
- 1:   abnormal hematopoietic precursor cell morphology [MP:0013707] <1>(0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
TNF receptor-like0.0000007486Direct
Interleukin 8-like chemokines0.0001906Direct
ARID-like0.0008043Direct
Integrin domains0.0008514Direct
Integrin beta tail domain0.002226Inherited
L30e-like0.008822Inherited
DNA polymerase beta, N-terminal domain-like0.01513Inherited
Notch domain0.01513Inherited
Flavoproteins0.02019Inherited
BRCT domain0.02726Inherited
AraD/HMP-PK domain-like0.03734Inherited
Triple coiled coil domain of C-type lectins0.03734Inherited
Terpenoid cyclases/Protein prenyltransferases0.04126Inherited
Toll/Interleukin receptor TIR domain0.0616Inherited
Integrin alpha N-terminal domain0.0616Inherited
A DNA-binding domain in eukaryotic transcription factors0.07377Inherited
Ran binding protein zinc finger-like0.07377Inherited
E2F-DP heterodimerization region0.08778Inherited
WWE domain0.08778Inherited
SH3-domain0.1281Inherited
TIMP-like0.1424Inherited
4-helical cytokines0.1464Inherited
SH2 domain0.2047Inherited
Cyclin-like0.215Inherited
Cysteine-rich domain0.2261Inherited
SMAD/FHA domain0.2472Inherited
DBL homology domain (DH-domain)0.271Inherited
SET domain0.2743Inherited
Nucleotidyltransferase0.3379Inherited
MHC antigen-recognition domain0.3483Inherited
Nucleic acid-binding proteins0.3483Inherited
BAR/IMD domain-like0.5379Inherited
Protein kinase-like (PK-like)0.5501Inherited
Ankyrin repeat0.5641Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.5769Inherited
Calponin-homology domain, CH-domain0.607Inherited
p53-like transcription factors0.6538Inherited
Bcl-2 inhibitors of programmed cell death0.666Inherited
DEATH domain0.7377Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.7686Inherited
Riboflavin synthase domain-like0.7686Inherited
Nuclear receptor ligand-binding domain0.8178Inherited
DNA/RNA polymerases0.999Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
STAT DNA-binding domain0Direct
BAFF receptor-like0Direct
STAT0Direct
beta-glycanases0Direct
Proteasome subunits0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Transcription factor STAT-4 N-domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
DNA polymerase beta-like0Direct
TNF receptor-like0.000002155Direct
Short-chain cytokines0.000002228Direct
Interleukin 8-like chemokines0.000133Direct
ARID domain0.0005397Direct
Integrin domains0.0006063Direct
Integrin beta tail domain0.001506Inherited
Interferons/interleukin-10 (IL-10)0.002561Inherited
Integrin beta EGF-like domains0.006343Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.006343Inherited
Pleckstrin-homology domain (PH domain)0.009352Inherited
Notch domain0.01102Inherited
DNA polymerase beta, N-terminal domain-like0.01102Inherited
Interleukin-1 (IL-1)0.01102Inherited
Myb/SANT domain0.01205Inherited
Pointed domain0.01512Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.01512Inherited
C2 set domains0.01626Inherited
Triple coiled coil domain of C-type lectins0.02827Inherited
Tissue inhibitor of metalloproteinases, TIMP0.02827Inherited
AraD-like aldolase/epimerase0.02827Inherited
Cytochrome p450 reductase N-terminal domain-like0.02827Inherited
Noncollagenous (NC1) domain of collagen IV0.03459Inherited
E2F dimerization segment0.03459Inherited
WWE domain0.03459Inherited
Erythroid transcription factor GATA-10.03468Inherited
A DNA-binding domain in eukaryotic transcription factors0.06123Inherited
Ran binding protein zinc finger-like0.06123Inherited
Interferon regulatory factor0.06386Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.07679Inherited
Tetraspanin0.07679Inherited
NADPH-cytochrome p450 reductase-like0.07679Inherited
Nuclear receptor coactivator interlocking domain0.07679Inherited
Toll/Interleukin receptor TIR domain0.08142Inherited
CCCH zinc finger0.08607Inherited
V set domains (antibody variable domain-like)0.08639Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.1018Inherited
SH3-domain0.1148Inherited
Eps15 homology domain (EH domain)0.1403Inherited
Cyclin0.1483Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.1647Inherited
Cell cycle transcription factor e2f-dp0.1765Inherited
SH2 domain0.1896Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.214Inherited
PLC-like (P variant)0.2355Inherited
C1 set domains (antibody constant domain-like)0.2545Inherited
DBL homology domain (DH-domain)0.2562Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.297Inherited
MHC antigen-recognition domain0.3211Inherited
DEATH domain, DD0.3211Inherited
ets domain0.3736Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.5127Inherited
FHA domain0.5288Inherited
Ankyrin repeat0.5474Inherited
Long-chain cytokines0.5477Inherited
Pyrin domain, PYD0.5921Inherited
Calponin-homology domain, CH-domain0.5949Inherited
Bcl-2 inhibitors of programmed cell death0.6389Inherited
Caspase recruitment domain, CARD0.6895Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.7734Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.7734Inherited
Nuclear receptor ligand-binding domain0.8044Inherited
Nuclear receptor0.8044Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.8056Inherited
MATH domain0.9277Inherited
DNA polymerase I0.9531Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.0000003029Direct
Interleukin 8-like chemokines0.00009593Direct
ARID-like0.0004338Direct
Integrin domains0.0004611Direct
Integrin beta tail domain0.001271Inherited
Immunoglobulin0.002196Inherited
L30e-like0.005456Inherited
DNA polymerase beta, N-terminal domain-like0.009711Inherited
Notch domain0.009711Inherited
Flavoproteins0.01326Inherited
BRCT domain0.01835Inherited
AraD/HMP-PK domain-like0.02579Inherited
Triple coiled coil domain of C-type lectins0.02579Inherited
Terpenoid cyclases/Protein prenyltransferases0.02871Inherited
TNF-like0.04116Inherited
C-type lectin-like0.04305Inherited
Toll/Interleukin receptor TIR domain0.04447Inherited
Integrin alpha N-terminal domain0.04447Inherited
(Trans)glycosidases0.0457Inherited
NAD kinase/diacylglycerol kinase-like0.04983Inherited
A DNA-binding domain in eukaryotic transcription factors0.05417Inherited
Ran binding protein zinc finger-like0.05417Inherited
WWE domain0.06544Inherited
E2F-DP heterodimerization region0.06544Inherited
PH domain-like0.06734Inherited
Nuclear receptor coactivator interlocking domain0.0707Inherited
CCCH zinc finger0.07755Inherited
SH3-domain0.09953Inherited
TIMP-like0.112Inherited
4-helical cytokines0.1155Inherited
SH2 domain0.1674Inherited
Cyclin-like0.1771Inherited
Cysteine-rich domain0.1875Inherited
SMAD/FHA domain0.2072Inherited
DBL homology domain (DH-domain)0.2294Inherited
SET domain0.2326Inherited
Nucleotidyltransferase0.2928Inherited
Nucleic acid-binding proteins0.303Inherited
MHC antigen-recognition domain0.303Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.3548Inherited
beta-beta-alpha zinc fingers0.3557Inherited
BAR/IMD domain-like0.4908Inherited
Protein kinase-like (PK-like)0.5033Inherited
Ankyrin repeat0.5175Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.5305Inherited
Calponin-homology domain, CH-domain0.5617Inherited
p53-like transcription factors0.6105Inherited
Bcl-2 inhibitors of programmed cell death0.6234Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.6442Inherited
Acyl-CoA N-acyltransferases (Nat)0.6872Inherited
DEATH domain0.699Inherited
Riboflavin synthase domain-like0.7312Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.7312Inherited
Nuclear receptor ligand-binding domain0.7842Inherited
DNA/RNA polymerases0.9858Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    49562,51045
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 51045 - WW domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0000003785Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000008703Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000004942Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.001271Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.001271Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.003143Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.003579Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.003579Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.005456Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.01326Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.01669Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.01669Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.02579Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.02579Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.02579Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.03107Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.05417Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.06544Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.07678Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.09254Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1249Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.1311Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.164Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1784Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.2767Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3284Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.5485Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.5754Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.6234Inherited
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.6234Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.681Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.7586Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.7909Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.8365Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00001133Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.001271Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.01266Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01326Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.01669Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.02579Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.03107Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1105Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2027Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)