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Mammalian Phenotype (MP): abnormal blood cell morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + 2:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
+ 1:   abnormal hematopoietic cell morphology [MP:0013656] <9>(49|77) (60|43|18)
0:   abnormal blood cell morphology [MP:0013657] <4>(31|49) (37|35|14)
- 1:   abnormal erythrocyte morphology [MP:0002447] <30>(6|12) (7|10|4)
- 1:   abnormal granulocyte morphology [MP:0002441] <6>(4|8) (6|6|2)
- 1:   abnormal platelet morphology [MP:0004720] <6>(1|3) (2|1|0)
- 1:   abnormal hemopoiesis [MP:0013693] <2>(25|34) (27|24|9)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
p53-like transcription factors0.00008684Direct
DNA polymerase beta, N-terminal domain-like0.004456Inherited
AraD/HMP-PK domain-like0.01462Inherited
Bcl-2 inhibitors of programmed cell death0.02366Inherited
E2F-DP heterodimerization region0.03158Inherited
SH2 domain0.03466Inherited
Cyclin-like0.04732Inherited
SMAD/FHA domain0.07491Inherited
4-helical cytokines0.133Inherited
Nucleotidyltransferase0.1441Inherited
A DNA-binding domain in eukaryotic transcription factors0.1907Inherited
DNA/RNA polymerases0.1983Inherited
BRCT domain0.249Inherited
BAR/IMD domain-like0.2519Inherited
Integrin beta tail domain0.2893Inherited
Cysteine-rich domain0.2986Inherited
SET domain0.3222Inherited
TIMP-like0.4035Inherited
TNF receptor-like0.4275Inherited
Notch domain0.4423Inherited
DEATH domain0.5299Inherited
Terpenoid cyclases/Protein prenyltransferases0.6274Inherited
Ankyrin repeat0.6281Inherited
DBL homology domain (DH-domain)0.6746Inherited
Calponin-homology domain, CH-domain0.7022Inherited
Protein kinase-like (PK-like)0.7303Inherited
SH3-domain0.7998Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT DNA-binding domain0Direct
RUNT domain0Direct
DNA polymerase beta-like0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
DNA polymerase beta-like, second domain0Direct
Short-chain cytokines0.00000004386Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00009579Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0007314Direct
DNA polymerase beta, N-terminal domain-like0.003127Inherited
Erythroid transcription factor GATA-10.009245Inherited
AraD-like aldolase/epimerase0.01075Inherited
Tissue inhibitor of metalloproteinases, TIMP0.01075Inherited
Noncollagenous (NC1) domain of collagen IV0.01104Inherited
E2F dimerization segment0.01104Inherited
PLC-like (P variant)0.01578Inherited
Bcl-2 inhibitors of programmed cell death0.01845Inherited
SH2 domain0.03054Inherited
Cyclin0.0344Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.05022Inherited
DNA polymerase I0.06243Inherited
Eps15 homology domain (EH domain)0.06243Inherited
Cell cycle transcription factor e2f-dp0.07075Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1017Inherited
Myb/SANT domain0.1056Inherited
A DNA-binding domain in eukaryotic transcription factors0.1666Inherited
Pleckstrin-homology domain (PH domain)0.2218Inherited
ets domain0.2252Inherited
Integrin beta tail domain0.2613Inherited
Integrin beta EGF-like domains0.2613Inherited
Pointed domain0.3281Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.3281Inherited
TNF receptor-like0.3463Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.3768Inherited
FHA domain0.395Inherited
Notch domain0.4112Inherited
Interleukin-1 (IL-1)0.4112Inherited
MATH domain0.4112Inherited
V set domains (antibody variable domain-like)0.4876Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.5102Inherited
DEATH domain, DD0.5656Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.5803Inherited
Pyrin domain, PYD0.6015Inherited
Ankyrin repeat0.6191Inherited
DBL homology domain (DH-domain)0.6576Inherited
Calponin-homology domain, CH-domain0.6836Inherited
Interleukin 17F, IL-17F0.6907Inherited
SH3-domain0.7998Inherited
Integrin domains0.8197Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
p53-like transcription factors0.00004168Direct
DNA polymerase beta, N-terminal domain-like0.002639Inherited
AraD/HMP-PK domain-like0.009377Inherited
Bcl-2 inhibitors of programmed cell death0.01573Inherited
E2F-DP heterodimerization region0.02158Inherited
SH2 domain0.02382Inherited
Cyclin-like0.03333Inherited
SMAD/FHA domain0.05508Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.06357Inherited
beta-beta-alpha zinc fingers0.08629Inherited
4-helical cytokines0.1038Inherited
Nucleotidyltransferase0.1136Inherited
A DNA-binding domain in eukaryotic transcription factors0.1548Inherited
DNA/RNA polymerases0.1617Inherited
PH domain-like0.1768Inherited
BRCT domain0.2088Inherited
BAR/IMD domain-like0.2115Inherited
Integrin beta tail domain0.2466Inherited
Cysteine-rich domain0.2554Inherited
SET domain0.278Inherited
TIMP-like0.3567Inherited
TNF receptor-like0.3807Inherited
Notch domain0.3948Inherited
DEATH domain0.4828Inherited
Acyl-CoA N-acyltransferases (Nat)0.5226Inherited
Terpenoid cyclases/Protein prenyltransferases0.5828Inherited
Ankyrin repeat0.5835Inherited
DBL homology domain (DH-domain)0.6326Inherited
Calponin-homology domain, CH-domain0.6614Inherited
Protein kinase-like (PK-like)0.6913Inherited
SH3-domain0.7649Inherited
Integrin domains0.8Inherited
C-type lectin-like0.9769Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00007163Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0007131Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0007131Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0009039Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.009166Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.009377Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.009377Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01406Inherited
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.01573Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.02158Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.05613Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.06303Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1343Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1402Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1956Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.1956Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2466Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.2466Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.2466Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2554Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.3124Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.3124Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3136Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.492Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5136Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.6326Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9995Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.009377Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03943Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.2466Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.3124Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.4839Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6209Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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