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Mammalian Phenotype (MP): abnormal cognition

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   behavior/neurological phenotype [MP:0005386] <1>(38|61) (42|40|24)
+ 1:   abnormal behavior [MP:0004924] <19>(37|56) (41|37|22)
0:   abnormal cognition [MP:0014114] <2>(13|16) (15|9|3)
- 1:   abnormal learning/memory/conditioning [MP:0002063] <16>(13|16) (15|9|3)
- 1:   cognitive inflexibility [MP:0014115](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Periplasmic binding protein-like I0.0004016Direct
Flavoproteins0.005631Inherited
Periplasmic binding protein-like II0.005717Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.01741Inherited
PYP-like sensor domain (PAS domain)0.02144Inherited
Family A G protein-coupled receptor-like0.02174Inherited
SNF-like0.02991Inherited
Protein kinase-like (PK-like)0.05127Inherited
Nuclear receptor ligand-binding domain0.05728Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.08046Inherited
Nicotinic receptor ligand binding domain-like0.08046Inherited
Voltage-gated potassium channels0.2843Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Synapsin C-terminal domain0Direct
Synapsin domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
L-arabinose binding protein-like0.0006109Direct
Phosphate binding protein-like0.004582Inherited
Rhodopsin-like0.006251Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.01321Inherited
Cytochrome p450 reductase N-terminal domain-like0.01321Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.02418Inherited
SNF-like0.02418Inherited
YWTD domain0.04112Inherited
Nuclear receptor ligand-binding domain0.05224Inherited
Nuclear receptor0.05224Inherited
Protein kinases, catalytic subunit0.0584Inherited
Nicotinic receptor ligand binding domain-like0.07322Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.07322Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Periplasmic binding protein-like I0.0002097Direct
Flavoproteins0.003392Inherited
Periplasmic binding protein-like II0.003443Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.01134Inherited
PYP-like sensor domain (PAS domain)0.01415Inherited
Family A G protein-coupled receptor-like0.01435Inherited
SNF-like0.02035Inherited
YWTD domain0.03483Inherited
Protein kinase-like (PK-like)0.03624Inherited
Nuclear receptor ligand-binding domain0.04101Inherited
Nicotinic receptor ligand binding domain-like0.0594Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.0594Inherited
Voltage-gated potassium channels0.2419Inherited
GTPase activation domain, GAP0.2838Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    52799,52799
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.001272Inherited
    50729,49562
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.001375Inherited
    50044,48065
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.003392Inherited
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.003392Inherited
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0.01134Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01506Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.02214Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0594Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,48065,50729
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.003392Inherited
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.03358Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.05403Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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