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Mammalian Phenotype (MP): abnormal embryo morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   embryo phenotype [MP:0005380] <7>(40|54) (46|28|19)
0:   abnormal embryo morphology [MP:0014134] <4>(23|31) (26|14|12)
- 1:   abnormal embryonic tissue morphology [MP:0002085] <35>(17|21) (19|10|9)
- 1:   abnormal embryo size [MP:0001697] <2>(3|11) (4|3|2)
- 1:   abnormal preimplantation embryo morphology [MP:0014137] <2>(3|2) (4|1|1)
- 1:   abnormal embryonic-extraembryonic boundary morphology [MP:0003890] <1>(2|2) (2|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SMAD MH1 domain0.00001097Direct
SMAD/FHA domain0.003843Inherited
Cullin repeat-like0.004884Inherited
Snake toxin-like0.008029Inherited
HCP-like0.01132Inherited
Cullin homology domain0.01132Inherited
Homeodomain-like0.02538Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.03511Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.04283Inherited
Integrin beta tail domain0.05801Inherited
Nucleic acid-binding proteins0.07772Inherited
Bromodomain0.07772Inherited
Nuclear receptor ligand-binding domain0.07772Inherited
HMG-box0.1839Inherited
TIMP-like0.3603Inherited
SAM/Pointed domain0.3727Inherited
WD40 repeat-like0.3782Inherited
Ankyrin repeat0.381Inherited
Histone-fold0.3927Inherited
Frizzled cysteine-rich domain0.4377Inherited
Cyclin-like0.4906Inherited
Cystine-knot cytokines0.6117Inherited
PDZ domain-like0.6639Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA ligase0Direct
Retinoblastoma tumor suppressor domains0Direct
SMAD MH1 domain0.000006926Direct
SMAD domain0.000006926Direct
Extracellular domain of cell surface receptors0.0001544Direct
DIX domain0.0001884Direct
Paired domain0.0006202Direct
Rel/Dorsal transcription factors, DNA-binding domain0.001491Inherited
Formate/glycerate dehydrogenases, substrate-binding domain0.004138Inherited
Tetrahydrofolate dehydrogenase/cyclohydrolase0.004138Inherited
C5 cytosine-specific DNA methylase, DCM0.004138Inherited
Cullin repeat0.004138Inherited
Cullin homology domain0.008428Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.008428Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.008428Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.01606Inherited
Formate/glycerate dehydrogenases, NAD-domain0.02722Inherited
Homeodomain0.03996Inherited
Integrin beta tail domain0.04672Inherited
DEP domain0.05752Inherited
Bromodomain0.0663Inherited
Forkhead DNA-binding domain0.0663Inherited
Nuclear receptor ligand-binding domain0.0663Inherited
Nuclear receptor0.0663Inherited
T-box0.1326Inherited
HMG-box0.1677Inherited
Ankyrin repeat0.3729Inherited
Frizzled cysteine-rich domain0.4176Inherited
Transforming growth factor (TGF)-beta0.4375Inherited
SAM (sterile alpha motif) domain0.5893Inherited
PDZ domain0.5952Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SMAD MH1 domain0.000004839Direct
SMAD/FHA domain0.002258Inherited
Cullin repeat-like0.002923Inherited
Snake toxin-like0.004943Inherited
Cullin homology domain0.007139Inherited
HCP-like0.007139Inherited
Homeodomain-like0.01698Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.02416Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.02989Inherited
Integrin beta tail domain0.04157Inherited
FYVE/PHD zinc finger0.05102Inherited
Nuclear receptor ligand-binding domain0.05721Inherited
Nucleic acid-binding proteins0.05721Inherited
Bromodomain0.05721Inherited
BRCT domain0.0993Inherited
HMG-box0.1488Inherited
TIMP-like0.3146Inherited
SAM/Pointed domain0.3267Inherited
WD40 repeat-like0.332Inherited
Ankyrin repeat0.3348Inherited
Histone-fold0.3462Inherited
Frizzled cysteine-rich domain0.3902Inherited
Cyclin-like0.4429Inherited
Cystine-knot cytokines0.5664Inherited
PDZ domain-like0.6214Inherited
FnI-like domain0.9253Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.001191Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.002923Inherited
    48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0.003548Inherited
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.003548Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.007139Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.01139Inherited
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.02416Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.04157Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0993Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2034Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.2724Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.703Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0001496Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.002923Inherited
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.003548Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.007139Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.04157Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1804Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.2424Inherited
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.4944Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.7768Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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