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Worm Phenotype (WP): cell homeostasis metabolism variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Variant [WBPhenotype:0000886] <2>
+ + 2:   physiology variant [WBPhenotype:0000519] <15>(509|582) (509|247|68)
+ 1:   cell physiology variant [WBPhenotype:0000536] <35>(156|154) (158|67|19)
0:   cell homeostasis metabolism variant [WBPhenotype:0000585] <12>(72|65) (73|28|12)
- 1:   cell stress response variant [WBPhenotype:0000142] <14>(36|30) (36|10|3)
- 1:   protein metabolism variant [WBPhenotype:0001644] <9>(30|26) (31|15|8)
- 1:   DNA metabolism variant [WBPhenotype:0000732] <7>(1|0) (1|0|0)
- 1:   chromosome segregation variant [WBPhenotype:0000773] <6>(10|9) (10|2|0)
- 1:   RNA metabolism variant [WBPhenotype:0001827] <5>(4|2) (4|2|0)
- 1:   organelle metabolism variant [WBPhenotype:0001283] <3>(1|2) (1|0|0)
- 1:   autophagy variant [WBPhenotype:0000736] <2>(0|1) (0|0|0)
- 1:   cell acidification variant [WBPhenotype:0001393] <2>(0|0) (0|0|0)
- 1:   chromosome instability [WBPhenotype:0000000] <2>(1|1) (1|0|0)
- 1:   telomere homeostasis variant [WBPhenotype:0001673] <1>(0|0) (0|0|0)
- 1:   endo lysosomal degradation pathway defective [WBPhenotype:0002236](0|0) (0|0|0)
- 1:   integrity of membranous organelles defective early emb [WBPhenotype:0000767](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
RBP11-like subunits of RNA polymerase0Direct
Heme-dependent catalase-like0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
HSP90 C-terminal domain0Direct
LEM domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
The spindle assembly checkpoint protein mad20Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Restriction endonuclease-like0Direct
Histone-fold0Direct
Arginase/deacetylase0.00000005053Direct
PIN domain-like0.00001787Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.00001889Direct
DHS-like NAD/FAD-binding domain0.0000685Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0000685Direct
Di-copper centre-containing domain0.000662Direct
Integrin domains0.0009133Direct
ADC-like0.0009133Direct
Cdc48 domain 2-like0.0009133Direct
Cu,Zn superoxide dismutase-like0.0009133Direct
PLC-like phosphodiesterases0.001722Inherited
Sec63 N-terminal domain-like0.003752Inherited
RING/U-box0.01628Inherited
SET domain0.02788Inherited
Nucleic acid-binding proteins0.02853Inherited
Protein kinase-like (PK-like)0.03017Inherited
Calpain large subunit, middle domain (domain III)0.03698Inherited
Smc hinge domain0.03698Inherited
Cyclin-like0.04333Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.06406Inherited
F1F0 ATP synthase subunit C0.06771Inherited
Zn-binding ribosomal proteins0.06771Inherited
Hect, E3 ligase catalytic domain0.06771Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.1232Inherited
L30e-like0.1255Inherited
P-loop containing nucleoside triphosphate hydrolases0.1663Inherited
Cysteine-rich domain0.1758Inherited
Lipocalins0.2109Inherited
Nucleotidylyl transferase0.2428Inherited
GroEL equatorial domain-like0.255Inherited
GroEL-intermediate domain like0.255Inherited
Immunoglobulin0.2592Inherited
Transducin (alpha subunit), insertion domain0.2628Inherited
RNA-binding domain, RBD0.3192Inherited
Saposin0.3597Inherited
Clavaminate synthase-like0.3597Inherited
Translation proteins0.3754Inherited
GroEL apical domain-like0.4027Inherited
Voltage-gated potassium channels0.4338Inherited
"Winged helix" DNA-binding domain0.4397Inherited
E set domains0.4678Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.5024Inherited
Spectrin repeat0.5274Inherited
Quinoprotein alcohol dehydrogenase-like0.5274Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.5843Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.6036Inherited
Cysteine proteinases0.6063Inherited
EF-hand0.6196Inherited
DNA/RNA polymerases0.6718Inherited
Chromo domain-like0.6718Inherited
PLP-dependent transferases0.6737Inherited
FYVE/PHD zinc finger0.6887Inherited
Metallo-dependent phosphatases0.7177Inherited
Sm-like ribonucleoproteins0.7905Inherited
BRCT domain0.8016Inherited
PH domain-like0.8765Inherited
Thioredoxin-like0.9345Inherited
SH3-domain0.9617Inherited
Homeodomain-like1Inherited
POZ domain1Inherited
MFS general substrate transporter1Inherited
Skp1 dimerisation domain-like1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
XPF/Rad1/Mus81 nuclease0Direct
Sir2 family of transcriptional regulators0Direct
5' to 3' exonuclease catalytic domain0Direct
Nucleosome core histones0Direct
HSP90 C-terminal domain0Direct
Hsp90 middle domain0Direct
LEM domain0Direct
Histone deacetylase, HDAC0Direct
Integrin domains0Direct
Smc hinge domain0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
RNA-polymerase beta0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Arginine methyltransferase0Direct
Heme-dependent catalases0Direct
Mammalian PLC0Direct
PLC-like (P variant)0.0000002282Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.000147Direct
Cyclin0.001216Inherited
Ubiquitin carboxyl-terminal hydrolase UCH-L0.001301Inherited
Cdc48 N-terminal domain-like0.001301Inherited
Hemocyanin middle domain0.001301Inherited
Cdc48 domain 2-like0.001301Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.004461Inherited
RING finger domain, C3HC40.00541Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.008004Inherited
Fatty acid binding protein-like0.01125Inherited
I set domains0.02207Inherited
Calpain large subunit, middle domain (domain III)0.03047Inherited
Calpain large subunit, catalytic domain (domain II)0.03047Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.03047Inherited
PHD domain0.0381Inherited
F1F0 ATP synthase subunit C0.05724Inherited
Hect, E3 ligase catalytic domain0.05724Inherited
Histone lysine methyltransferases0.06157Inherited
Pleckstrin-homology domain (PH domain)0.06305Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.06479Inherited
Protein kinases, catalytic subunit0.09412Inherited
Elongation factors0.09718Inherited
EF-hand modules in multidomain proteins0.1064Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.1064Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.1064Inherited
Tandem AAA-ATPase domain0.1329Inherited
Cold shock DNA-binding domain-like0.1532Inherited
Motor proteins0.1635Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.1863Inherited
Proteasome subunits0.3222Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.335Inherited
Spectrin repeat0.335Inherited
Erythroid transcription factor GATA-10.335Inherited
Transducin (alpha subunit), insertion domain0.3582Inherited
Glutathione peroxidase-like0.434Inherited
LIM domain0.4718Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.4718Inherited
Canonical RBD0.4893Inherited
Group II chaperonin (CCT, TRIC), apical domain0.4957Inherited
G proteins0.5124Inherited
Voltage-gated potassium channels0.6387Inherited
ABC transporter ATPase domain-like0.6503Inherited
Glutathione S-transferase (GST), N-terminal domain0.6866Inherited
BTB/POZ domain1Inherited
Skp1 dimerisation domain-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
5' to 3' exonuclease, C-terminal subdomain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Restriction endonuclease-like0Direct
Histone-fold0Direct
HSP90 C-terminal domain0Direct
RBP11-like subunits of RNA polymerase0Direct
The spindle assembly checkpoint protein mad20Direct
LEM domain0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Heme-dependent catalase-like0Direct
Arginase/deacetylase0.00000004058Direct
PIN domain-like0.0000146Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.00001544Direct
DHS-like NAD/FAD-binding domain0.00005616Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.00005616Direct
Di-copper centre-containing domain0.0005502Direct
Cdc48 domain 2-like0.0007613Direct
Cu,Zn superoxide dismutase-like0.0007613Direct
ADC-like0.0007613Direct
Integrin domains0.0007613Direct
PLC-like phosphodiesterases0.001444Inherited
Sec63 N-terminal domain-like0.003181Inherited
RING/U-box0.01412Inherited
SET domain0.02445Inherited
Nucleic acid-binding proteins0.02504Inherited
Protein kinase-like (PK-like)0.0265Inherited
Smc hinge domain0.03263Inherited
Calpain large subunit, middle domain (domain III)0.03263Inherited
Cyclin-like0.03833Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.05719Inherited
Zn-binding ribosomal proteins0.06051Inherited
F1F0 ATP synthase subunit C0.06051Inherited
Hect, E3 ligase catalytic domain0.06051Inherited
Fibronectin type III0.07726Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.1118Inherited
L30e-like0.1139Inherited
P-loop containing nucleoside triphosphate hydrolases0.1524Inherited
Cysteine-rich domain0.1614Inherited
Lipocalins0.1947Inherited
Nucleotidylyl transferase0.2254Inherited
GroEL equatorial domain-like0.2371Inherited
GroEL-intermediate domain like0.2371Inherited
Immunoglobulin0.2413Inherited
Transducin (alpha subunit), insertion domain0.2449Inherited
RNA-binding domain, RBD0.2997Inherited
Saposin0.3395Inherited
Clavaminate synthase-like0.3395Inherited
Translation proteins0.355Inherited
GroEL apical domain-like0.382Inherited
Voltage-gated potassium channels0.4129Inherited
"Winged helix" DNA-binding domain0.4187Inherited
E set domains0.4467Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.4807Inherited
Spectrin repeat0.5057Inherited
Quinoprotein alcohol dehydrogenase-like0.5057Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.5626Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.582Inherited
Cysteine proteinases0.5846Inherited
EF-hand0.5978Inherited
DNA/RNA polymerases0.6507Inherited
Chromo domain-like0.6507Inherited
PLP-dependent transferases0.6526Inherited
FYVE/PHD zinc finger0.6676Inherited
Metallo-dependent phosphatases0.6972Inherited
Sm-like ribonucleoproteins0.7718Inherited
BRCT domain0.783Inherited
PH domain-like0.8606Inherited
Thioredoxin-like0.9212Inherited
SH3-domain0.9493Inherited
MFS general substrate transporter1Inherited
POZ domain1Inherited
Homeodomain-like1Inherited
Skp1 dimerisation domain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.00005616Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0007613Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0007613Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.002606Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.03263Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.03542Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.03542Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.1029Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.1118Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1977Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.2371Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.2371Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2449Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3456Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.4507Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.4807Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.9187Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.00005616Direct
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.06051Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1584Inherited
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.2371Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.4807Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.6485Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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