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Worm Phenotype (WP): gene expression variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <2>
+ + + + 4:   physiology variant [WBPhenotype:0000519] <15>(509|582) (509|247|68)
+ + + 3:   organism physiology variant [WBPhenotype:0000576] <11>(366|425) (369|192|56)
+ + 2:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(358|416) (360|189|55)
+ 1:   organism metabolism processing variant [WBPhenotype:0000027] <25>(176|187) (179|86|26)
0:   gene expression variant [WBPhenotype:0000717] <10>(124|136) (127|63|20)
- 1:   RNA expression variant [WBPhenotype:0000113] <10>(19|16) (20|5|0)
- 1:   protein expression variant [WBPhenotype:0000112] <6>(39|44) (39|19|6)
- 1:   dosage compensation variant [WBPhenotype:0000718] <3>(1|0) (1|0|0)
- 1:   transgene expression variant [WBPhenotype:0000306] <3>(84|98) (86|43|14)
- 1:   gene expression level high [WBPhenotype:0000135] <1>(2|2) (2|0|0)
- 1:   gene expression level reduced [WBPhenotype:0000134] <1>(6|3) (6|0|0)
- 1:   drug induced gene expression variant [WBPhenotype:0001838](5|6) (5|2|0)
- 1:   environmental stimuli induced gene expression variant [WBPhenotype:0001861](0|0) (0|0|0)
- 1:   pathogen induced gene expression variant [WBPhenotype:0001857](1|1) (1|0|0)
- 1:   pattern of gene expression variant [WBPhenotype:0000111](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
TK C-terminal domain-like0Direct
Ribosomal protein L10Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Heme-dependent catalase-like0Direct
MIR domain0Direct
Zn-finger domain of Sec23/240Direct
GroEL equatorial domain-like0Direct
ISP domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
HSP90 C-terminal domain0Direct
F1F0 ATP synthase subunit C0Direct
S-adenosylmethionine synthetase0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
SMAD MH1 domain0Direct
GroEL-intermediate domain like0Direct
14-3-3 protein0Direct
Nop domain0Direct
Tubulin nucleotide-binding domain-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cytochrome c0Direct
Helical domain of Sec23/240Direct
Clathrin adaptor appendage domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Ribosomal protein L10-like0Direct
Tubulin C-terminal domain-like0Direct
Class II aaRS ABD-related0Direct
JAB1/MPN domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
GroEL apical domain-like0Direct
FF domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Cullin homology domain0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Chromo domain-like0.0000000002096Direct
FYVE/PHD zinc finger0.000000008619Direct
SET domain0.00000007327Direct
Class II aaRS and biotin synthetases0.000002669Direct
Acid proteases0.000002669Direct
RING/U-box0.000003255Direct
SNARE-like0.000007226Direct
Translation proteins0.00001334Direct
Bromodomain0.00003712Direct
Translation proteins SH3-like domain0.00006248Direct
Cullin repeat-like0.00007653Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00007653Direct
Arginase/deacetylase0.00007653Direct
Hect, E3 ligase catalytic domain0.00007653Direct
CCCH zinc finger0.00008038Direct
PAP/OAS1 substrate-binding domain0.0001023Direct
B-box zinc-binding domain0.0001612Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0001731Direct
Cyclophilin-like0.000396Direct
ARM repeat0.0006915Direct
ACP-like0.0007385Direct
ENTH/VHS domain0.000879Direct
Sm-like ribonucleoproteins0.0009794Direct
"Winged helix" DNA-binding domain0.001034Inherited
RNA-binding domain, RBD0.001336Inherited
L30e-like0.001431Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.001431Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.001901Inherited
Tudor/PWWP/MBT0.00225Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.002259Inherited
P-loop containing nucleoside triphosphate hydrolases0.002716Inherited
Activating enzymes of the ubiquitin-like proteins0.003914Inherited
Riboflavin synthase domain-like0.003914Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.003914Inherited
PAZ domain0.004349Inherited
FKBP-like0.00481Inherited
Leucine zipper domain0.006605Inherited
4Fe-4S ferredoxins0.006788Inherited
Frizzled cysteine-rich domain0.006788Inherited
Zn-binding ribosomal proteins0.01038Inherited
dsRNA-binding domain-like0.01055Inherited
DHS-like NAD/FAD-binding domain0.01178Inherited
Single hybrid motif0.01193Inherited
Histone-fold0.01376Inherited
Saposin0.01717Inherited
Integrin domains0.02011Inherited
ADC-like0.02011Inherited
Cdc48 domain 2-like0.02011Inherited
p53-like transcription factors0.0218Inherited
Cyclin-like0.0218Inherited
HIT/MYND zinc finger-like0.0219Inherited
PH domain-like0.02246Inherited
PX domain0.02446Inherited
Homeodomain-like0.02699Inherited
SH3-domain0.02919Inherited
UBC-like0.03344Inherited
Actin-like ATPase domain0.04373Inherited
Chaperone J-domain0.04373Inherited
HLH, helix-loop-helix DNA-binding domain0.04997Inherited
PDZ domain-like0.05581Inherited
Cysteine-rich domain0.06522Inherited
CAD & PB1 domains0.06665Inherited
Tubby C-terminal domain-like0.06665Inherited
S15/NS1 RNA-binding domain0.06665Inherited
ARID-like0.06665Inherited
Protein kinase-like (PK-like)0.06736Inherited
Quinoprotein alcohol dehydrogenase-like0.07447Inherited
HSP20-like chaperones0.08484Inherited
Nucleic acid-binding proteins0.08904Inherited
SAM/Pointed domain0.1286Inherited
Cysteine proteinases0.1367Inherited
KA1-like0.1378Inherited
GTPase activation domain, GAP0.1719Inherited
Transducin (alpha subunit), insertion domain0.2389Inherited
HMG-box0.2389Inherited
SH2 domain0.2429Inherited
Nucleotidyltransferase0.2709Inherited
Second domain of FERM0.3702Inherited
Nucleotidylyl transferase0.3974Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.4138Inherited
Intermediate filament protein, coiled coil region0.4397Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4774Inherited
Spectrin repeat0.4959Inherited
PYP-like sensor domain (PAS domain)0.4959Inherited
Lamin A/C globular tail domain0.4959Inherited
Ribonuclease H-like0.6475Inherited
Clavaminate synthase-like0.669Inherited
Nuclear receptor ligand-binding domain0.8878Inherited
ClpP/crotonase1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Sir2 family of transcriptional regulators0Direct
POU-specific domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
ValRS/IleRS/LeuRS editing domain0Direct
Brix domain0Direct
Proteasome subunits0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
HSP90 C-terminal domain0Direct
Clathrin coat assembly domain0Direct
SMAD MH1 domain0Direct
Hsp90 middle domain0Direct
RecA protein-like (ATPase-domain)0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Histone deacetylase, HDAC0Direct
beta-sandwich domain of Sec23/240Direct
Clathrin adaptor core protein0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Integrin domains0Direct
PDI-like0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
p120GAP domain-like0Direct
MIF4G domain-like0Direct
L30e/L7ae ribosomal proteins0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
CAT-like0Direct
Tubulin, GTPase domain0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
Erythroid transcription factor GATA-10Direct
Zn-finger domain of Sec23/240Direct
Ribosomal protein L10Direct
F1F0 ATP synthase subunit C0Direct
a tRNA synthase domain0Direct
Nop domain0Direct
Tubulin, C-terminal domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
14-3-3 protein0Direct
Helical domain of Sec23/240Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Trunk domain of Sec23/240Direct
HSP200Direct
RNA-polymerase beta0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
S-adenosylmethionine synthetase0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
MIR domain0Direct
Cullin homology domain0Direct
Chromo domain0Direct
FF domain0Direct
Anticodon-binding domain of Class II aaRS0Direct
Acyl-carrier protein (ACP)0Direct
Adenain-like0Direct
Cullin repeat0Direct
Heme-dependent catalases0Direct
Cu,Zn superoxide dismutase-like0Direct
ets domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Mammalian PLC0Direct
Actin/HSP700.000000003062Direct
UBC-related0.00000005643Direct
Forkhead DNA-binding domain0.0000002309Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.0000009716Direct
PHD domain0.0000009733Direct
Pepsin-like0.000002498Direct
Dual specificity phosphatase-like0.000002498Direct
Histone lysine methyltransferases0.00003464Direct
Papain-like0.00003832Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.00005168Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0001328Direct
Bromodomain0.0001963Direct
Hect, E3 ligase catalytic domain0.0002443Direct
Armadillo repeat0.0002564Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0006506Direct
SMAD domain0.0006506Direct
Translational machinery components0.0006506Direct
CCCH zinc finger0.00071Direct
B-box zinc-binding domain0.0008611Direct
Cyclophilin (peptidylprolyl isomerase)0.001809Inherited
TBP-associated factors, TAFs0.002402Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.003682Inherited
PDZ domain0.004507Inherited
Canonical RBD0.004557Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.006649Inherited
Extended PAW domain0.007564Inherited
Cold shock DNA-binding domain-like0.008625Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0117Inherited
Pumilio repeat0.0117Inherited
FKBP immunophilin/proline isomerase0.0117Inherited
Frizzled cysteine-rich domain0.01185Inherited
Transforming growth factor (TGF)-beta0.01185Inherited
EF-hand modules in multidomain proteins0.01185Inherited
Ubiquitin activating enzymes (UBA)0.01185Inherited
Elongation factors0.01581Inherited
Homeodomain0.01679Inherited
PAZ domain0.02269Inherited
RING finger domain, C3HC40.02371Inherited
Leucine zipper domain0.02543Inherited
Biotinyl/lipoyl-carrier proteins and domains0.02775Inherited
Cdc48 N-terminal domain-like0.03083Inherited
Cdc48 domain 2-like0.03083Inherited
Biotin dependent carboxylase carboxyltransferase domain0.03083Inherited
Anticodon-binding domain0.03083Inherited
Nucleosome core histones0.03524Inherited
Chaperone J-domain0.0407Inherited
HLH, helix-loop-helix DNA-binding domain0.04654Inherited
Cyclin0.04798Inherited
PX domain0.05418Inherited
SH3-domain0.06165Inherited
DEP domain0.09911Inherited
G proteins0.1088Inherited
Pleckstrin-homology domain (PH domain)0.1451Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1532Inherited
First domain of FERM0.1979Inherited
Extended AAA-ATPase domain0.219Inherited
Transducin (alpha subunit), insertion domain0.2263Inherited
PLC-like (P variant)0.3312Inherited
N-acetyl transferase, NAT0.3441Inherited
Double-stranded RNA-binding domain (dsRBD)0.3802Inherited
Third domain of FERM0.3802Inherited
Intermediate filament protein, coiled coil region0.4245Inherited
Second domain of FERM0.464Inherited
Synaptotagmin-like (S variant)0.464Inherited
LIM domain0.4782Inherited
Protein kinases, catalytic subunit0.5232Inherited
Spectrin repeat0.5398Inherited
Lamin A/C globular tail domain0.5398Inherited
Ubiquitin-related0.5682Inherited
SH2 domain0.584Inherited
Nuclear receptor ligand-binding domain1Inherited
Nuclear receptor1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nop domain0Direct
SMAD MH1 domain0Direct
FF domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Helical domain of Sec23/240Direct
Subdomain of clathrin and coatomer appendage domain0Direct
GroEL apical domain-like0Direct
MIR domain0Direct
TK C-terminal domain-like0Direct
Ribosomal protein L10Direct
Cu,Zn superoxide dismutase-like0Direct
Zn-finger domain of Sec23/240Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
JAB1/MPN domain0Direct
Clathrin adaptor appendage domain0Direct
HSP90 C-terminal domain0Direct
Cullin homology domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Tubulin C-terminal domain-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
F1F0 ATP synthase subunit C0Direct
S-adenosylmethionine synthetase0Direct
Ribosomal protein L10-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
GroEL equatorial domain-like0Direct
Class II aaRS ABD-related0Direct
GroEL-intermediate domain like0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
ISP domain0Direct
Tubulin nucleotide-binding domain-like0Direct
14-3-3 protein0Direct
Cytochrome c0Direct
Heme-dependent catalase-like0Direct
Chromo domain-like0.0000000001666Direct
FYVE/PHD zinc finger0.000000006894Direct
SET domain0.0000000589Direct
Class II aaRS and biotin synthetases0.000002172Direct
Acid proteases0.000002172Direct
RING/U-box0.000002652Direct
SNARE-like0.000005893Direct
Translation proteins0.0000109Direct
Bromodomain0.0000304Direct
Translation proteins SH3-like domain0.00005121Direct
Cullin repeat-like0.00006277Direct
Hect, E3 ligase catalytic domain0.00006277Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00006277Direct
Arginase/deacetylase0.00006277Direct
CCCH zinc finger0.00006597Direct
PAP/OAS1 substrate-binding domain0.00008401Direct
B-box zinc-binding domain0.0001327Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0001425Direct
Cyclophilin-like0.000328Direct
ARM repeat0.0005751Direct
ACP-like0.0006149Direct
ENTH/VHS domain0.0007327Direct
Sm-like ribonucleoproteins0.0008169Direct
"Winged helix" DNA-binding domain0.0008631Direct
RNA-binding domain, RBD0.001118Inherited
L30e-like0.001198Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.001198Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.001596Inherited
Tudor/PWWP/MBT0.001894Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.001902Inherited
Sec1/munc18-like (SM) proteins0.001902Inherited
P-loop containing nucleoside triphosphate hydrolases0.002294Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.003319Inherited
Activating enzymes of the ubiquitin-like proteins0.003319Inherited
Riboflavin synthase domain-like0.003319Inherited
PAZ domain0.00369Inherited
FKBP-like0.004088Inherited
Leucine zipper domain0.005645Inherited
Frizzled cysteine-rich domain0.005802Inherited
4Fe-4S ferredoxins0.005802Inherited
Zn-binding ribosomal proteins0.008947Inherited
dsRNA-binding domain-like0.009091Inherited
DHS-like NAD/FAD-binding domain0.01017Inherited
Single hybrid motif0.0103Inherited
Histone-fold0.01191Inherited
Saposin0.0149Inherited
Cdc48 domain 2-like0.0175Inherited
ADC-like0.0175Inherited
Integrin domains0.0175Inherited
p53-like transcription factors0.01901Inherited
Cyclin-like0.01901Inherited
HIT/MYND zinc finger-like0.01909Inherited
PH domain-like0.0196Inherited
PX domain0.02139Inherited
Homeodomain-like0.02366Inherited
SH3-domain0.02563Inherited
UBC-like0.02943Inherited
Actin-like ATPase domain0.0387Inherited
Chaperone J-domain0.0387Inherited
HLH, helix-loop-helix DNA-binding domain0.04436Inherited
PDZ domain-like0.04965Inherited
Cysteine-rich domain0.05824Inherited
CAD & PB1 domains0.05954Inherited
Tubby C-terminal domain-like0.05954Inherited
ARID-like0.05954Inherited
S15/NS1 RNA-binding domain0.05954Inherited
Protein kinase-like (PK-like)0.06019Inherited
Quinoprotein alcohol dehydrogenase-like0.06674Inherited
HSP20-like chaperones0.07639Inherited
Nucleic acid-binding proteins0.08025Inherited
SAM/Pointed domain0.1169Inherited
Cysteine proteinases0.1245Inherited
KA1-like0.1255Inherited
GTPase activation domain, GAP0.1578Inherited
HMG-box0.2216Inherited
Transducin (alpha subunit), insertion domain0.2216Inherited
Eukaryotic type KH-domain (KH-domain type I)0.2216Inherited
SH2 domain0.2255Inherited
Nucleotidyltransferase0.2527Inherited
Second domain of FERM0.3497Inherited
Nucleotidylyl transferase0.3768Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.393Inherited
Intermediate filament protein, coiled coil region0.4187Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4562Inherited
Lamin A/C globular tail domain0.4746Inherited
Spectrin repeat0.4746Inherited
PYP-like sensor domain (PAS domain)0.4746Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.537Inherited
Ribonuclease H-like0.6261Inherited
Clavaminate synthase-like0.6476Inherited
Nuclear receptor ligand-binding domain0.8727Inherited
ClpP/crotonase0.9986Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    144232,82199
  • 144232 - HIT/MYND zinc finger-like
  • 82199 - SET domain
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0.00005121Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.00006277Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.00008401Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.0003452Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.0003452Direct
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.0006149Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.001198Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.001198Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.001874Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.001902Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.004379Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.005802Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.008212Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.008947Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.008947Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0175Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.0387Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.03883Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.05954Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1494Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2216Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.2682Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.3711Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.4873Inherited
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0.537Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.537Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.6022Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.7441Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.00006277Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.001198Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.01017Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.4071Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.4187Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4187Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.6022Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.9597Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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