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Worm Phenotype (WP): early embryonic lethal

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Variant [WBPhenotype:0000886] <2>
+ + + + + 5:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|68)
+ + + + 4:   development variant [WBPhenotype:0000518] <6>(508|585) (508|248|68)
+ + + 3:   organism development variant [WBPhenotype:0000531] <10>(505|583) (505|248|68)
+ + 2:   lethal [WBPhenotype:0000062] <5>(497|580) (497|247|68)
+ + 2:   embryonic development variant [WBPhenotype:0000749] <21>(437|529) (437|228|63)
+ 1:   embryonic lethal [WBPhenotype:0000050] <7>(433|528) (433|227|63)
0:   early embryonic lethal [WBPhenotype:0001100] <24>(40|39) (40|12|3)
- 1:   aster defective early emb [WBPhenotype:0001110] <3>(0|0) (0|0|0)
- 1:   cytokinesis defective early emb [WBPhenotype:0001078] <3>(5|8) (5|0|0)
- 1:   cell position defective early emb [WBPhenotype:0001118] <2>(1|0) (1|0|0)
- 1:   cytoplasmic appearance defective early emb [WBPhenotype:0000769] <2>(6|6) (6|2|0)
- 1:   egg integrity defective early emb [WBPhenotype:0001178] <2>(2|1) (2|0|0)
- 1:   embryonic morphology defective early emb [WBPhenotype:0001135] <2>(0|0) (0|0|0)
- 1:   other abnormality early emb [WBPhenotype:0001007] <2>(11|6) (11|2|1)
- 1:   polar body defective early emb [WBPhenotype:0001147] <2>(2|2) (2|1|0)
- 1:   pseudocleavage defective early emb [WBPhenotype:0001167] <2>(0|0) (0|0|0)
- 1:   spindle defective early emb [WBPhenotype:0000759] <2>(7|11) (7|4|0)
- 1:   cell cell contacts abnormal early emb [WBPhenotype:0001117] <1>(2|1) (2|0|0)
- 1:   cell cycle defective early emb [WBPhenotype:0001114] <1>(2|2) (2|0|0)
- 1:   embryonic developmental delay early emb [WBPhenotype:0001185] <1>(0|0) (0|0|0)
- 1:   meiosis defective early emb [WBPhenotype:0001041] <1>(3|4) (3|0|0)
- 1:   pronuclear nuclear appearance defective early emb [WBPhenotype:0001034] <1>(5|6) (5|3|0)
- 1:   Aba ABp division axis defective early emb [WBPhenotype:0001134](1|1) (1|1|0)
- 1:   asymmetric cell division defective early emb [WBPhenotype:0000748](0|0) (0|0|0)
- 1:   centrosome attachment defective early emb [WBPhenotype:0000771](0|0) (0|0|0)
- 1:   chromosome segregation variant karyomeres early emb [WBPhenotype:0001077](1|1) (1|1|0)
- 1:   cortical dynamics defective early emb [WBPhenotype:0001044](0|0) (0|0|0)
- 1:   egg size defective early emb [WBPhenotype:0000044](0|0) (0|0|0)
- 1:   integrity of membranous organelles defective early emb [WBPhenotype:0000767](0|0) (0|0|0)
- 1:   interphase entry defective early emb [WBPhenotype:0001043](0|0) (0|0|0)
- 1:   one cell arrest early emb [WBPhenotype:0000040](2|3) (2|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
P-loop containing nucleoside triphosphate hydrolases0Direct
Histone-fold0Direct
Skp1 dimerisation domain-like4.49e-16Direct
ARM repeat0.0000000000002001Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000000000001172Direct
GroEL-intermediate domain like0.000000000178Direct
GroEL equatorial domain-like0.000000000178Direct
GroEL apical domain-like0.000000001646Direct
Nucleic acid-binding proteins0.00000001027Direct
Zn-binding ribosomal proteins0.00000003406Direct
Class II aaRS and biotin synthetases0.00000007861Direct
Translation proteins SH3-like domain0.0000008782Direct
Tubulin C-terminal domain-like0.000002303Direct
S15/NS1 RNA-binding domain0.000006177Direct
TPR-like0.000009708Direct
Prefoldin0.00001069Direct
Activating enzymes of the ubiquitin-like proteins0.00001069Direct
"Winged helix" DNA-binding domain0.00001135Direct
Tubulin nucleotide-binding domain-like0.0000165Direct
Cyclin-like0.00003604Direct
Sm-like ribonucleoproteins0.00004781Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.00008111Direct
ADC-like0.00008111Direct
Cdc48 domain 2-like0.00008111Direct
Class II aaRS ABD-related0.0002566Direct
CAD & PB1 domains0.0003604Direct
L30e-like0.0005252Direct
Translation proteins0.0006765Direct
Smc hinge domain0.0009702Direct
Translational machinery components0.0009702Direct
WD40 repeat-like0.001904Inherited
Calponin-homology domain, CH-domain0.001954Inherited
Nucleotidylyl transferase0.004626Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01322Inherited
Invertebrate chitin-binding proteins0.01814Inherited
POZ domain0.02975Inherited
GTPase activation domain, GAP0.03441Inherited
UBC-like0.1735Inherited
BAR/IMD domain-like0.2059Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3002Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
a tRNA synthase domain0Direct
Nucleosome core histones0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Proteasome subunits0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Anticodon-binding domain of Class II aaRS0Direct
Skp1 dimerisation domain-like0.000000000000002504Direct
Extended AAA-ATPase domain0.000000000005676Direct
Group II chaperonin (CCT, TRIC), apical domain0.0000000008215Direct
Armadillo repeat0.000000003986Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.0000001079Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.000001153Direct
Cyclin0.000001296Direct
BTB/POZ domain0.000004611Direct
Prefoldin0.000007228Direct
Tubulin, C-terminal domain0.000009387Direct
Ubiquitin activating enzymes (UBA)0.0000126Direct
Motor proteins0.00002334Direct
Tubulin, GTPase domain0.00005511Direct
Cdc48 domain 2-like0.0001358Direct
Cdc48 N-terminal domain-like0.0001358Direct
Pumilio repeat0.0001591Direct
G proteins0.0001661Direct
Translational machinery components0.0005072Direct
L30e/L7ae ribosomal proteins0.0005995Direct
Smc hinge domain0.0005995Direct
DEP domain0.0005995Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0009652Direct
Cold shock DNA-binding domain-like0.001083Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.001121Inherited
Actin/HSP700.00148Inherited
WD40-repeat0.004242Inherited
Calponin-homology domain, CH-domain0.005464Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01498Inherited
BCR-homology GTPase activation domain (BH-domain)0.06083Inherited
PDZ domain0.09179Inherited
UBC-related0.2958Inherited
Protein serine/threonine phosphatase0.3053Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3438Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
P-loop containing nucleoside triphosphate hydrolases0Direct
Histone-fold0Direct
Skp1 dimerisation domain-like3.517e-16Direct
ARM repeat0.0000000000001573Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0000000000009235Direct
GroEL equatorial domain-like0.000000000141Direct
GroEL-intermediate domain like0.000000000141Direct
GroEL apical domain-like0.000000001308Direct
Nucleic acid-binding proteins0.000000008194Direct
Zn-binding ribosomal proteins0.00000002723Direct
Class II aaRS and biotin synthetases0.00000006296Direct
Translation proteins SH3-like domain0.0000007092Direct
Tubulin C-terminal domain-like0.000001866Direct
S15/NS1 RNA-binding domain0.000005021Direct
TPR-like0.000007897Direct
Prefoldin0.0000087Direct
Activating enzymes of the ubiquitin-like proteins0.0000087Direct
"Winged helix" DNA-binding domain0.00000924Direct
Tubulin nucleotide-binding domain-like0.00001344Direct
Cyclin-like0.00002943Direct
Sm-like ribonucleoproteins0.0000391Direct
Cdc48 domain 2-like0.00006638Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.00006638Direct
ADC-like0.00006638Direct
Class II aaRS ABD-related0.0002111Direct
CAD & PB1 domains0.0002971Direct
L30e-like0.0004346Direct
Translation proteins0.0005611Direct
Translational machinery components0.0008075Direct
Smc hinge domain0.0008075Direct
WD40 repeat-like0.001596Inherited
Calponin-homology domain, CH-domain0.001638Inherited
Nucleotidylyl transferase0.003927Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01142Inherited
Invertebrate chitin-binding proteins0.01576Inherited
POZ domain0.02611Inherited
GTPase activation domain, GAP0.03028Inherited
UBC-like0.1592Inherited
BAR/IMD domain-like0.1898Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2811Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.000000000000001055Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.000000000141Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000000141Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.000003679Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.00001344Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00001344Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.00006638Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.0002968Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08228Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000000141Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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