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Worm Phenotype (WP): organism metabolism processing variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Variant [WBPhenotype:0000886] <4>
+ + + 3:   physiology variant [WBPhenotype:0000519] <7>(489|563) (489|241|65)
+ + 2:   organism physiology variant [WBPhenotype:0000576] <10>(357|420) (358|193|57)
+ 1:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(347|410) (350|191|56)
0:   organism metabolism processing variant [WBPhenotype:0000027] <25>(171|182) (176|81|24)
- 1:   gene expression variant [WBPhenotype:0000717] <10>(122|134) (129|62|19)
- 1:   lipid metabolism variant [WBPhenotype:0000725] <8>(21|28) (22|8|4)
- 1:   metabolic pathway variant [WBPhenotype:0000463] <8>(35|28) (35|16|8)
- 1:   enzyme activity variant [WBPhenotype:0000727] <5>(6|6) (6|1|0)
- 1:   neurotransmitter metabolism variant [WBPhenotype:0000221] <4>(0|0) (0|0|0)
- 1:   protein interaction variant [WBPhenotype:0001369] <3>(48|48) (48|21|9)
- 1:   ATP levels variant [WBPhenotype:0001574] <2>(2|2) (2|1|0)
- 1:   biogenic amine physiology variant [WBPhenotype:0001518] <2>(0|0) (0|0|0)
- 1:   heme levels variant [WBPhenotype:0002480] <2>(0|0) (0|0|0)
- 1:   energy expenditure variant [WBPhenotype:0001835] <1>(0|0) (0|0|0)
- 1:   glutathione levels variant [WBPhenotype:0001899] <1>(1|1) (1|0|0)
- 1:   neuropeptide metabolism variant [WBPhenotype:0001757] <1>(0|0) (0|0|0)
- 1:   post translational processing variant [WBPhenotype:0000122] <1>(0|0) (0|0|0)
- 1:   GABA levels variant [WBPhenotype:0000552](0|0) (0|0|0)
- 1:   acetylcholine levels variant [WBPhenotype:0000507](0|0) (0|0|0)
- 1:   carbohydrate metabolism variant [WBPhenotype:0002072](0|0) (0|0|0)
- 1:   dietary sugar response variant [WBPhenotype:0002273](0|0) (0|0|0)
- 1:   galactose metabolism variant [WBPhenotype:0002206](0|0) (0|0|0)
- 1:   glucose intolerant [WBPhenotype:0002400](0|0) (0|0|0)
- 1:   glycation variant [WBPhenotype:0002008](0|0) (0|0|0)
- 1:   glycogen levels variant [WBPhenotype:0001892](0|0) (0|0|0)
- 1:   hormone metabolism variant [WBPhenotype:0001843](0|0) (0|0|0)
- 1:   hypersensitive to galactose [WBPhenotype:0002205](0|0) (0|0|0)
- 1:   nonsense mRNA accumulation [WBPhenotype:0000508](2|1) (2|0|0)
- 1:   pheromone production variant [WBPhenotype:0002381](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
MIR domain0Direct
HSP90 C-terminal domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
TK C-terminal domain-like0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Tubulin nucleotide-binding domain-like0Direct
S-adenosylmethionine synthetase0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Tubulin C-terminal domain-like0Direct
Nop domain0Direct
SMAD MH1 domain0Direct
LDH C-terminal domain-like0Direct
Helical domain of Sec23/240Direct
JAB1/MPN domain0Direct
14-3-3 protein0Direct
LEM domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
L-aspartase-like0Direct
Cullin homology domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Cytochrome c0Direct
Heme-dependent catalase-like0Direct
FF domain0Direct
F1F0 ATP synthase subunit C0Direct
Clathrin adaptor appendage domain0Direct
ISP domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
GroEL equatorial domain-like0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Class II aaRS ABD-related0Direct
Oxysterol-binding protein-like0Direct
Ribosomal protein L10-like0Direct
Zn-finger domain of Sec23/240Direct
GroEL-intermediate domain like0Direct
Cu,Zn superoxide dismutase-like0Direct
GroEL apical domain-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Ribosomal protein L10Direct
RING/U-box0.0000000000004742Direct
ARM repeat0.000000000001464Direct
Histone-fold0.0000000009255Direct
Cysteine proteinases0.000000005812Direct
UBC-like0.00000002299Direct
P-loop containing nucleoside triphosphate hydrolases0.00000002354Direct
"Winged helix" DNA-binding domain0.00000003664Direct
HSP20-like chaperones0.00000007255Direct
WD40 repeat-like0.00000007943Direct
Homeodomain-like0.0000002753Direct
RNA-binding domain, RBD0.00000161Direct
Acyl-CoA dehydrogenase NM domain-like0.000002739Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000002739Direct
Chaperone J-domain0.000002885Direct
Class II aaRS and biotin synthetases0.00001703Direct
PH domain-like0.00002466Direct
Acid proteases0.00003121Direct
SNARE-like0.00003185Direct
Cysteine-rich domain0.0000648Direct
Actin-like ATPase domain0.000122Direct
Translation proteins SH3-like domain0.000215Direct
Hect, E3 ligase catalytic domain0.0002187Direct
Nucleotidylyl transferase0.0002208Direct
HLH, helix-loop-helix DNA-binding domain0.0002223Direct
Translation proteins0.0002742Direct
beta-beta-alpha zinc fingers0.0002806Direct
Thiolase-like0.0002839Direct
PAP/OAS1 substrate-binding domain0.0003303Direct
Ubiquitin-like0.0004428Direct
Nucleotidyltransferase0.0005447Direct
B-box zinc-binding domain0.0006666Direct
Cullin repeat-like0.0006872Direct
Arginase/deacetylase0.0006872Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0006872Direct
ClpP/crotonase0.001111Inherited
HMG-box0.001111Inherited
Cyclophilin-like0.001448Inherited
CCCH zinc finger0.001528Inherited
Galactose-binding domain-like0.001584Inherited
PYP-like sensor domain (PAS domain)0.001653Inherited
Sm-like ribonucleoproteins0.003378Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.005774Inherited
Nucleic acid-binding proteins0.006536Inherited
CoA-dependent acyltransferases0.00676Inherited
Calpain large subunit, middle domain (domain III)0.008168Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.008168Inherited
Riboflavin synthase domain-like0.008168Inherited
L30e-like0.008564Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.008564Inherited
ENTH/VHS domain0.008615Inherited
Lipovitellin-phosvitin complex, superhelical domain0.009312Inherited
Sec1/munc18-like (SM) proteins0.009312Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.009312Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.009312Inherited
FKBP-like0.0107Inherited
Ribosomal protein S5 domain 2-like0.01141Inherited
Frizzled cysteine-rich domain0.01183Inherited
4Fe-4S ferredoxins0.01183Inherited
Intermediate filament protein, coiled coil region0.0128Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0128Inherited
SMAD/FHA domain0.01456Inherited
Lipocalins0.01535Inherited
PAZ domain0.01613Inherited
GST C-terminal domain-like0.01744Inherited
Activating enzymes of the ubiquitin-like proteins0.0181Inherited
Seven-hairpin glycosidases0.01921Inherited
Leucine zipper domain0.02033Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.02328Inherited
DHS-like NAD/FAD-binding domain0.02329Inherited
ADC-like0.03108Inherited
MIT domain0.03108Inherited
UBA-like0.03199Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.03437Inherited
Zn-binding ribosomal proteins0.03755Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.03794Inherited
Transducin (alpha subunit), insertion domain0.04054Inherited
Saposin0.04769Inherited
SH3-domain0.04815Inherited
Integrin domains0.05026Inherited
WWE domain0.05026Inherited
Cdc48 domain 2-like0.05026Inherited
Lamin A/C globular tail domain0.05542Inherited
Single hybrid motif0.05542Inherited
Spectrin repeat0.05542Inherited
PX domain0.05542Inherited
p53-like transcription factors0.06125Inherited
SET domain0.07984Inherited
S15/NS1 RNA-binding domain0.09818Inherited
FYVE/PHD zinc finger0.1001Inherited
Acetyl-CoA synthetase-like0.124Inherited
Cyclin-like0.124Inherited
Thioredoxin-like0.1443Inherited
HSP40/DnaJ peptide-binding domain0.1489Inherited
Tubby C-terminal domain-like0.1489Inherited
CAD & PB1 domains0.1489Inherited
ARID-like0.1489Inherited
dsRNA-binding domain-like0.1572Inherited
FAD/NAD(P)-binding domain0.1584Inherited
KA1-like0.1937Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2021Inherited
Fibronectin type III0.2095Inherited
Quinoprotein alcohol dehydrogenase-like0.2124Inherited
cAMP-binding domain-like0.2347Inherited
Calcium ATPase, transmembrane domain M0.2646Inherited
DNA/RNA polymerases0.2803Inherited
GTPase activation domain, GAP0.3215Inherited
EF-hand0.3704Inherited
Eukaryotic type KH-domain (KH-domain type I)0.3741Inherited
Protein kinase-like (PK-like)0.3761Inherited
SH2 domain0.4295Inherited
Skp1 dimerisation domain-like0.6064Inherited
Second domain of FERM0.6855Inherited
Nuclear receptor ligand-binding domain0.6967Inherited
Periplasmic binding protein-like II0.731Inherited
Snake toxin-like0.8403Inherited
Chromo domain-like0.8741Inherited
Ribonuclease H-like0.8822Inherited
Immunoglobulin0.9266Inherited
Clavaminate synthase-like0.9395Inherited
Cytochrome P4501Inherited
Voltage-gated potassium channels1Inherited
POZ domain1Inherited
RNI-like1Inherited
alpha/beta-Hydrolases1Inherited
Periplasmic binding protein-like I1Inherited
PapD-like1Inherited
F-box domain1Inherited
Nucleotide cyclase1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Helical domain of Sec23/240Direct
L30e/L7ae ribosomal proteins0Direct
MIR domain0Direct
LEM domain0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Cullin homology domain0Direct
Adenain-like0Direct
Zn-finger domain of Sec23/240Direct
PDI-like0Direct
FF domain0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Trunk domain of Sec23/240Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
Clathrin coat assembly domain0Direct
HSP200Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
ets domain0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
Histone deacetylase, HDAC0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Ribosomal protein L10Direct
RNA-polymerase beta0Direct
Mammalian PLC0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Tubulin, GTPase domain0Direct
Cullin repeat0Direct
Proteasome subunits0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
CAT-like0Direct
SMAD MH1 domain0Direct
14-3-3 protein0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Acyl-carrier protein (ACP)0Direct
Erythroid transcription factor GATA-10Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
RecA protein-like (ATPase-domain)0Direct
POU-specific domain0Direct
S-adenosylmethionine synthetase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
Heme-dependent catalases0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Integrin domains0Direct
Nop domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
a tRNA synthase domain0Direct
HSP90 C-terminal domain0Direct
LDH N-terminal domain-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
MIF4G domain-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Tubulin, C-terminal domain0Direct
Anticodon-binding domain of Class II aaRS0Direct
beta-sandwich domain of Sec23/240Direct
Brix domain0Direct
p120GAP domain-like0Direct
HCDH C-domain-like0Direct
Clathrin adaptor core protein0Direct
Oxysterol-binding protein0Direct
Hsp90 middle domain0Direct
Sir2 family of transcriptional regulators0Direct
F1F0 ATP synthase subunit C0Direct
DEATH domain, DD0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Homeodomain0.0000003798Direct
Actin/HSP700.0000006548Direct
UBC-related0.0000008509Direct
Nucleosome core histones0.000006504Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.000007132Direct
Pepsin-like0.00001618Direct
G proteins0.00003499Direct
Pleckstrin-homology domain (PH domain)0.00005883Direct
Chaperone J-domain0.00006647Direct
Dual specificity phosphatase-like0.00009544Direct
Fatty acid binding protein-like0.0002134Direct
RING finger domain, C3HC40.0003237Direct
Papain-like0.0003301Direct
Tetratricopeptide repeat (TPR)0.0003383Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.000357Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0003867Direct
PLC-like (P variant)0.0004505Direct
Hect, E3 ligase catalytic domain0.0007137Direct
Ubiquitin-related0.000735Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0008092Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0008745Direct
WD40-repeat0.00118Inherited
Canonical RBD0.001183Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.001281Inherited
HLH, helix-loop-helix DNA-binding domain0.00285Inherited
Armadillo repeat0.002882Inherited
B-box zinc-binding domain0.003467Inherited
Thiolase-related0.004173Inherited
SMAD domain0.004173Inherited
Translational machinery components0.004173Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.004173Inherited
HMG-box0.005047Inherited
Cyclophilin (peptidylprolyl isomerase)0.006461Inherited
TBP-associated factors, TAFs0.00687Inherited
acyl-CoA oxidase N-terminal domains0.00865Inherited
acyl-CoA oxidase C-terminal domains0.00865Inherited
CCCH zinc finger0.00964Inherited
Histone lysine methyltransferases0.01387Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01792Inherited
Sec1/munc18-like (SM) proteins0.01792Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01792Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.01814Inherited
Crotonase-like0.01814Inherited
Calpain large subunit, middle domain (domain III)0.01845Inherited
Gastric lipase0.01845Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.02014Inherited
Extended PAW domain0.0212Inherited
EF-hand modules in multidomain proteins0.02122Inherited
Frizzled cysteine-rich domain0.02122Inherited
Transforming growth factor (TGF)-beta0.02122Inherited
LIM domain0.0263Inherited
FKBP immunophilin/proline isomerase0.0263Inherited
Intermediate filament protein, coiled coil region0.03206Inherited
Extended AAA-ATPase domain0.0327Inherited
Ubiquitin activating enzymes (UBA)0.03692Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.03788Inherited
Cdc48 N-terminal domain-like0.04866Inherited
MIT domain0.04866Inherited
Bacterial lipase0.04866Inherited
PDZ domain0.0525Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.05536Inherited
Pumilio repeat0.05536Inherited
Choline/Carnitine O-acyltransferase0.05812Inherited
Elongation factors0.06301Inherited
PAZ domain0.0711Inherited
Leucine zipper domain0.07219Inherited
Anticodon-binding domain0.07538Inherited
Cdc48 domain 2-like0.07538Inherited
WWE domain0.07538Inherited
Biotin dependent carboxylase carboxyltransferase domain0.07538Inherited
Cold shock DNA-binding domain-like0.07872Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.08406Inherited
Lamin A/C globular tail domain0.09338Inherited
Glutathione S-transferase (GST), N-terminal domain0.09669Inherited
Biotinyl/lipoyl-carrier proteins and domains0.1133Inherited
PX domain0.1133Inherited
Transducin (alpha subunit), insertion domain0.1208Inherited
PHD domain0.1557Inherited
Spectrin repeat0.1769Inherited
GABA-aminotransferase-like0.1769Inherited
DEP domain0.2138Inherited
Cyclin0.2226Inherited
SH3-domain0.2407Inherited
Glutathione S-transferase (GST), C-terminal domain0.2455Inherited
I set domains0.301Inherited
Acetyl-CoA synthetase-like0.3064Inherited
First domain of FERM0.3776Inherited
Calmodulin-like0.5376Inherited
Calpain large subunit, catalytic domain (domain II)0.6106Inherited
Synaptotagmin-like (S variant)0.6266Inherited
Third domain of FERM0.6476Inherited
N-acetyl transferase, NAT0.7077Inherited
Phosphate binding protein-like0.7286Inherited
Double-stranded RNA-binding domain (dsRBD)0.7845Inherited
Second domain of FERM0.7881Inherited
SH2 domain0.8017Inherited
Skp1 dimerisation domain-like0.8901Inherited
Nuclear receptor ligand-binding domain1Inherited
BTB/POZ domain1Inherited
Acetylcholinesterase-like1Inherited
Cytochrome P4501Inherited
Adenylyl and guanylyl cyclase catalytic domain1Inherited
Nuclear receptor1Inherited
MSP-like1Inherited
Voltage-gated potassium channels1Inherited
F-box domain1Inherited
Protein kinases, catalytic subunit1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
S-adenosylmethionine synthetase0Direct
Zn-finger domain of Sec23/240Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Ribosomal protein L10-like0Direct
Class II aaRS ABD-related0Direct
HSP90 C-terminal domain0Direct
Cu,Zn superoxide dismutase-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
LDH C-terminal domain-like0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
FF domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
GroEL apical domain-like0Direct
Tubulin nucleotide-binding domain-like0Direct
F1F0 ATP synthase subunit C0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
GroEL equatorial domain-like0Direct
14-3-3 protein0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Helical domain of Sec23/240Direct
Clathrin adaptor appendage domain0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
MIR domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Nop domain0Direct
LEM domain0Direct
TK C-terminal domain-like0Direct
Cytochrome c0Direct
Cullin homology domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Tubulin C-terminal domain-like0Direct
Ribosomal protein L10Direct
L-aspartase-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
GroEL-intermediate domain like0Direct
ISP domain0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Heme-dependent catalase-like0Direct
Oxysterol-binding protein-like0Direct
JAB1/MPN domain0Direct
SMAD MH1 domain0Direct
RING/U-box0.0000000000003755Direct
ARM repeat0.000000000001161Direct
Histone-fold0.0000000007397Direct
Cysteine proteinases0.000000004661Direct
UBC-like0.0000000185Direct
P-loop containing nucleoside triphosphate hydrolases0.00000001894Direct
"Winged helix" DNA-binding domain0.00000002951Direct
HSP20-like chaperones0.0000000585Direct
WD40 repeat-like0.00000006407Direct
Homeodomain-like0.0000002228Direct
RNA-binding domain, RBD0.000001313Direct
Acyl-CoA dehydrogenase NM domain-like0.000002236Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000002236Direct
Chaperone J-domain0.000002356Direct
Class II aaRS and biotin synthetases0.00001397Direct
PH domain-like0.00002023Direct
Acid proteases0.00002564Direct
SNARE-like0.00002616Direct
Cysteine-rich domain0.00005339Direct
Actin-like ATPase domain0.0001008Direct
Translation proteins SH3-like domain0.0001777Direct
Hect, E3 ligase catalytic domain0.0001808Direct
Nucleotidylyl transferase0.0001826Direct
HLH, helix-loop-helix DNA-binding domain0.0001838Direct
Translation proteins0.0002271Direct
beta-beta-alpha zinc fingers0.0002324Direct
Thiolase-like0.0002352Direct
PAP/OAS1 substrate-binding domain0.0002739Direct
Ubiquitin-like0.0003678Direct
Nucleotidyltransferase0.0004533Direct
B-box zinc-binding domain0.0005563Direct
Arginase/deacetylase0.0005738Direct
Cullin repeat-like0.0005738Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0005738Direct
ClpP/crotonase0.0009313Direct
HMG-box0.0009313Direct
Cyclophilin-like0.001216Inherited
CCCH zinc finger0.001284Inherited
Galactose-binding domain-like0.001332Inherited
PYP-like sensor domain (PAS domain)0.00139Inherited
Sm-like ribonucleoproteins0.002864Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.004925Inherited
Nucleic acid-binding proteins0.005586Inherited
CoA-dependent acyltransferases0.005779Inherited
Calpain large subunit, middle domain (domain III)0.007009Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.007009Inherited
Riboflavin synthase domain-like0.007009Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.007353Inherited
L30e-like0.007353Inherited
ENTH/VHS domain0.007398Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.008005Inherited
Sec1/munc18-like (SM) proteins0.008005Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.008005Inherited
Lipovitellin-phosvitin complex, superhelical domain0.008005Inherited
FKBP-like0.009217Inherited
Ribosomal protein S5 domain 2-like0.009832Inherited
Frizzled cysteine-rich domain0.0102Inherited
4Fe-4S ferredoxins0.0102Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01105Inherited
Intermediate filament protein, coiled coil region0.01105Inherited
SMAD/FHA domain0.01258Inherited
Lipocalins0.01328Inherited
PAZ domain0.01396Inherited
GST C-terminal domain-like0.01512Inherited
Activating enzymes of the ubiquitin-like proteins0.0157Inherited
Seven-hairpin glycosidases0.0167Inherited
Leucine zipper domain0.0177Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.02032Inherited
DHS-like NAD/FAD-binding domain0.02033Inherited
ADC-like0.0273Inherited
MIT domain0.0273Inherited
UBA-like0.0281Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.03026Inherited
Zn-binding ribosomal proteins0.03313Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.03348Inherited
Transducin (alpha subunit), insertion domain0.03581Inherited
Saposin0.04227Inherited
SH3-domain0.04269Inherited
Cdc48 domain 2-like0.04458Inherited
Integrin domains0.04458Inherited
WWE domain0.04458Inherited
PX domain0.04924Inherited
Spectrin repeat0.04924Inherited
Single hybrid motif0.04924Inherited
Lamin A/C globular tail domain0.04924Inherited
p53-like transcription factors0.05455Inherited
SET domain0.07166Inherited
S15/NS1 RNA-binding domain0.08858Inherited
FYVE/PHD zinc finger0.09038Inherited
Acetyl-CoA synthetase-like0.1127Inherited
Cyclin-like0.1127Inherited
Thioredoxin-like0.1318Inherited
Tubby C-terminal domain-like0.1361Inherited
CAD & PB1 domains0.1361Inherited
ARID-like0.1361Inherited
HSP40/DnaJ peptide-binding domain0.1361Inherited
dsRNA-binding domain-like0.1439Inherited
FAD/NAD(P)-binding domain0.145Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1518Inherited
KA1-like0.1782Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1863Inherited
Fibronectin type III0.1933Inherited
Quinoprotein alcohol dehydrogenase-like0.1961Inherited
cAMP-binding domain-like0.2175Inherited
Calcium ATPase, transmembrane domain M0.2464Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2507Inherited
DNA/RNA polymerases0.2616Inherited
GTPase activation domain, GAP0.3017Inherited
Insulin-like0.3137Inherited
PDZ domain-like0.332Inherited
Calponin-homology domain, CH-domain0.3367Inherited
EF-hand0.3499Inherited
Eukaryotic type KH-domain (KH-domain type I)0.3537Inherited
Protein kinase-like (PK-like)0.3556Inherited
SH2 domain0.4081Inherited
Skp1 dimerisation domain-like0.5842Inherited
Second domain of FERM0.6645Inherited
Nuclear receptor ligand-binding domain0.676Inherited
Periplasmic binding protein-like II0.7106Inherited
Snake toxin-like0.8225Inherited
Chromo domain-like0.8578Inherited
Ribonuclease H-like0.8661Inherited
Immunoglobulin0.9125Inherited
Clavaminate synthase-like0.9258Inherited
Periplasmic binding protein-like I0.9952Inherited
F-box domain1Inherited
Cytochrome P4501Inherited
alpha/beta-Hydrolases1Inherited
POZ domain1Inherited
PapD-like1Inherited
Voltage-gated potassium channels1Inherited
Nucleotide cyclase1Inherited
RNI-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.0000007041Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.000002236Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.00000321Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0.0001318Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0005738Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.001257Inherited
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.001382Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.001659Inherited
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0.003356Inherited
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.003356Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.003356Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.00368Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.003776Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.005443Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.007353Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.007353Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.008005Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.008005Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.009082Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.01123Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01396Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0167Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01891Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0273Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.03026Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.03313Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.03313Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03581Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.0391Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.04269Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.04351Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.05689Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.07513Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.08858Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.131Inherited
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.1361Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1482Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1863Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.2971Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4668Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.5376Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.6228Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.7614Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9259Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0001808Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0005738Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.003356Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.004069Inherited
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.007353Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.008005Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.008005Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.02033Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1461Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.24Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2616Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.677Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.804Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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