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Worm Phenotype (WP): metabolic pathway variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <4>
+ + + + 4:   physiology variant [WBPhenotype:0000519] <7>(487|558) (487|240|64)
+ + + 3:   organism physiology variant [WBPhenotype:0000576] <10>(355|415) (355|191|56)
+ + 2:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(346|406) (348|189|55)
+ 1:   organism metabolism processing variant [WBPhenotype:0000027] <25>(171|182) (175|80|24)
0:   metabolic pathway variant [WBPhenotype:0000463] <8>(35|28) (35|16|8)
- 1:   protein metabolism variant [WBPhenotype:0001644] <10>(28|24) (28|15|8)
- 1:   DNA metabolism variant [WBPhenotype:0000732] <7>(1|0) (1|0|0)
- 1:   RNA metabolism variant [WBPhenotype:0001827] <6>(1|1) (1|1|0)
- 1:   biosynthesis variant [WBPhenotype:0001696] <5>(0|0) (0|0|0)
- 1:   amino acid metabolism variant [WBPhenotype:0002255](0|0) (0|0|0)
- 1:   metabolite content decreased [WBPhenotype:0002270](1|1) (1|0|0)
- 1:   metabolite content increased [WBPhenotype:0002357](0|0) (0|0|0)
- 1:   second messenger mediated signaling variant [WBPhenotype:0001841](3|2) (3|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SET domain0.0000002362Direct
Protein kinase-like (PK-like)0.0000004961Direct
Integrin domains0.00003241Direct
Cdc48 domain 2-like0.00003241Direct
ADC-like0.00003241Direct
Calpain large subunit, middle domain (domain III)0.00005783Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0.0003348Direct
Lipovitellin-phosvitin complex, superhelical domain0.0003348Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.0003808Direct
Fibronectin type III0.0004516Direct
PH domain-like0.001023Inherited
GroEL equatorial domain-like0.0026Inherited
GroEL-intermediate domain like0.0026Inherited
Voltage-gated potassium channels0.003634Inherited
cAMP-binding domain-like0.004511Inherited
Spectrin repeat0.004511Inherited
GroEL apical domain-like0.005305Inherited
F1F0 ATP synthase subunit C0.007401Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.01789Inherited
DNA/RNA polymerases0.01789Inherited
Quinoprotein alcohol dehydrogenase-like0.01802Inherited
FYVE/PHD zinc finger0.02181Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.03757Inherited
CCCH zinc finger0.03757Inherited
Translation proteins0.03757Inherited
Immunoglobulin0.04016Inherited
SNARE-like0.06464Inherited
Clavaminate synthase-like0.0929Inherited
Cyclin-like0.1148Inherited
Sm-like ribonucleoproteins0.1965Inherited
Transducin (alpha subunit), insertion domain0.2404Inherited
Nucleotide cyclase0.2629Inherited
Periplasmic binding protein-like I0.3082Inherited
Cytochrome P4500.5699Inherited
Homeodomain-like0.8443Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Integrin domains0Direct
Histone lysine methyltransferases0.00003835Direct
Cdc48 N-terminal domain-like0.00005657Direct
Cdc48 domain 2-like0.00005657Direct
Calpain large subunit, middle domain (domain III)0.00005772Direct
Protein kinases, catalytic subunit0.0001053Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0002451Direct
Lipovitellin-phosvitin complex, superhelical domain0.0003219Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0.0003219Direct
Calpain large subunit, catalytic domain (domain II)0.0004728Direct
Pleckstrin-homology domain (PH domain)0.0006372Direct
Spectrin repeat0.001557Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.001767Inherited
I set domains0.002915Inherited
F1F0 ATP synthase subunit C0.007128Inherited
Proteasome subunits0.008962Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.009754Inherited
Elongation factors0.009872Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.01748Inherited
Group II chaperonin (CCT, TRIC), apical domain0.01815Inherited
Voltage-gated potassium channels0.01909Inherited
Clathrin adaptor core protein0.03374Inherited
LIM domain0.03374Inherited
CCCH zinc finger0.04022Inherited
PHD domain0.04618Inherited
Transducin (alpha subunit), insertion domain0.2452Inherited
Adenylyl and guanylyl cyclase catalytic domain0.3753Inherited
Cytochrome P4500.7407Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SET domain0.0000001912Direct
Protein kinase-like (PK-like)0.0000004023Direct
Integrin domains0.00002664Direct
ADC-like0.00002664Direct
Cdc48 domain 2-like0.00002664Direct
Calpain large subunit, middle domain (domain III)0.00004766Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0.0002777Direct
Lipovitellin-phosvitin complex, superhelical domain0.0002777Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.000316Direct
Fibronectin type III0.0003753Direct
PH domain-like0.0008574Direct
GroEL-intermediate domain like0.002198Inherited
GroEL equatorial domain-like0.002198Inherited
Voltage-gated potassium channels0.003084Inherited
Spectrin repeat0.003836Inherited
cAMP-binding domain-like0.003836Inherited
GroEL apical domain-like0.004521Inherited
F1F0 ATP synthase subunit C0.006343Inherited
DNA/RNA polymerases0.01552Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.01552Inherited
Quinoprotein alcohol dehydrogenase-like0.01564Inherited
FYVE/PHD zinc finger0.01902Inherited
CCCH zinc finger0.03316Inherited
Translation proteins0.03316Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.03316Inherited
Immunoglobulin0.03549Inherited
SNARE-like0.0577Inherited
Clavaminate synthase-like0.08371Inherited
Cyclin-like0.104Inherited
Sm-like ribonucleoproteins0.1809Inherited
Transducin (alpha subunit), insertion domain0.2229Inherited
Nucleotide cyclase0.2447Inherited
Periplasmic binding protein-like I0.2887Inherited
Cytochrome P4500.5477Inherited
Homeodomain-like0.8268Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.00004766Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.0002777Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.0002777Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.001584Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.002198Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.002198Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.003836Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.004235Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.004521Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.006343Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.008272Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0341Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.04005Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2229Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.0002777Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.002198Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.006343Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.006343Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.02221Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0501Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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