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Worm Phenotype (WP): chemical response variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <4>
+ + + + 4:   physiology variant [WBPhenotype:0000519] <7>(487|558) (487|240|64)
+ + + 3:   organism physiology variant [WBPhenotype:0000576] <10>(355|415) (355|191|56)
+ + 2:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(346|406) (348|189|55)
+ 1:   organism environmental stimulus response variant [WBPhenotype:0000738] <16>(115|103) (118|51|16)
0:   chemical response variant [WBPhenotype:0000523] <11>(65|58) (66|25|6)
- 1:   drug response variant [WBPhenotype:0000631] <27>(41|37) (42|16|2)
- 1:   chemical hypersensitive [WBPhenotype:0001918] <5>(7|7) (7|4|1)
- 1:   response to food variant [WBPhenotype:0001072] <4>(2|2) (2|0|0)
- 1:   chemosensory response variant [WBPhenotype:0001040] <3>(20|20) (20|5|0)
- 1:   chemical resistant [WBPhenotype:0001502] <2>(0|0) (0|0|0)
- 1:   bis phenol A response variant [WBPhenotype:0000931] <1>(0|0) (0|0|0)
- 1:   organism toxic chemical response variant [WBPhenotype:0001379] <1>(0|0) (0|0|0)
- 1:   growth inhibition response to chemical [WBPhenotype:0002125](0|0) (0|0|0)
- 1:   high pH avoidance defective [WBPhenotype:0002385](0|0) (0|0|0)
- 1:   neurotransmitter response variant [WBPhenotype:0002399](0|0) (0|0|0)
- 1:   unfolded protein response variant [WBPhenotype:0001719](6|5) (6|4|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Skp1 dimerisation domain-like0.0000000000005804Direct
Nicotinic receptor ligand binding domain-like0.00000000002996Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000005509Direct
Cullin repeat-like0.000000007625Direct
Cullin homology domain0.0000006181Direct
Protein kinase-like (PK-like)0.000006606Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.00004104Direct
cAMP-binding domain-like0.00009696Direct
Periplasmic binding protein-like II0.0001836Direct
Periplasmic binding protein-like I0.0003074Direct
Myosin rod fragments0.003379Inherited
Transducin (alpha subunit), insertion domain0.00369Inherited
Quinoprotein alcohol dehydrogenase-like0.006676Inherited
TPR-like0.01774Inherited
Voltage-gated potassium channels0.01937Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.02032Inherited
Cysteine-rich domain0.02218Inherited
PRTase-like0.02441Inherited
ENTH/VHS domain0.02799Inherited
Multidrug efflux transporter AcrB transmembrane domain0.03254Inherited
PDZ domain-like0.0344Inherited
Spectrin repeat0.04198Inherited
Immunoglobulin0.0447Inherited
Calcium ATPase, transmembrane domain M0.05543Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.05543Inherited
Calcium ATPase, transduction domain A0.05543Inherited
Troponin coil-coiled subunits0.07537Inherited
Glutathione synthetase ATP-binding domain-like0.08549Inherited
SMAD/FHA domain0.08549Inherited
Regulator of G-protein signaling, RGS0.08737Inherited
SAM/Pointed domain0.08737Inherited
WD40 repeat-like0.1008Inherited
SH3-domain0.1093Inherited
Nucleotide cyclase0.1103Inherited
EGF/Laminin0.13Inherited
t-snare proteins0.1336Inherited
SNARE-like0.1336Inherited
Cystine-knot cytokines0.2069Inherited
POZ domain0.2164Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.2187Inherited
Lipovitellin-phosvitin complex, superhelical domain0.2187Inherited
PH domain-like0.2775Inherited
GroEL equatorial domain-like0.2788Inherited
GroEL-intermediate domain like0.2788Inherited
GroEL apical domain-like0.2788Inherited
P-loop containing nucleoside triphosphate hydrolases0.3153Inherited
Tubulin nucleotide-binding domain-like0.3241Inherited
Sm-like ribonucleoproteins0.332Inherited
HAD-like0.3544Inherited
Bromodomain0.3916Inherited
Tubulin C-terminal domain-like0.4629Inherited
"Winged helix" DNA-binding domain0.542Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.6215Inherited
ABC transporter transmembrane region0.7232Inherited
Homeodomain-like0.8071Inherited
Nucleic acid-binding proteins0.8772Inherited
DBL homology domain (DH-domain)0.8935Inherited
Leucine zipper domain0.9022Inherited
HLH, helix-loop-helix DNA-binding domain0.952Inherited
Nuclear receptor ligand-binding domain0.9897Inherited
beta-beta-alpha zinc fingers1Inherited
Ankyrin repeat1Inherited
Family A G protein-coupled receptor-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain0Direct
Cullin repeat0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Skp1 dimerisation domain-like0.000000000075Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000001182Direct
Nicotinic receptor ligand binding domain-like0.0000000001182Direct
Protein kinases, catalytic subunit0.000001393Direct
Cullin homology domain0.000001881Direct
cAMP-binding domain0.0001558Direct
Phosphate binding protein-like0.0001558Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.0004944Direct
BTB/POZ domain0.001034Inherited
Transforming growth factor (TGF)-beta0.002884Inherited
Transducin (alpha subunit), insertion domain0.004135Inherited
L-arabinose binding protein-like0.004135Inherited
Synaptotagmin-like (S variant)0.005583Inherited
PLC-like (P variant)0.007Inherited
Clathrin coat assembly domain0.01477Inherited
Phosphoribosyltransferases (PRTases)0.01477Inherited
I set domains0.01981Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.03289Inherited
Multidrug efflux transporter AcrB transmembrane domain0.03289Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.03739Inherited
Spectrin repeat0.04078Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.05688Inherited
Calcium ATPase, transduction domain A0.05688Inherited
PDZ domain0.05688Inherited
Pleckstrin-homology domain (PH domain)0.06276Inherited
G proteins0.08443Inherited
Regulator of G-protein signaling, RGS0.08677Inherited
SH3-domain0.1178Inherited
Adenylyl and guanylyl cyclase catalytic domain0.1216Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.1286Inherited
t-snare proteins0.1286Inherited
Meta-cation ATPase, catalytic domain P0.1311Inherited
Voltage-gated potassium channels0.1742Inherited
Pyridoxal-dependent decarboxylase0.2164Inherited
Lipovitellin-phosvitin complex, superhelical domain0.2164Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.2164Inherited
Calcium ATPase, transmembrane domain M0.2799Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.329Inherited
Tubulin, GTPase domain0.3297Inherited
WD40-repeat0.3418Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.3916Inherited
Bromodomain0.3916Inherited
Group II chaperonin (CCT, TRIC), apical domain0.3916Inherited
Tubulin, C-terminal domain0.4701Inherited
Rhodopsin-like0.7287Inherited
ABC transporter transmembrane region0.8197Inherited
ABC transporter ATPase domain-like0.8241Inherited
DBL homology domain (DH-domain)0.8987Inherited
Leucine zipper domain0.9056Inherited
HLH, helix-loop-helix DNA-binding domain0.9575Inherited
Nuclear receptor ligand-binding domain0.993Inherited
Nuclear receptor1Inherited
Ankyrin repeat1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Skp1 dimerisation domain-like0.0000000000004599Direct
Nicotinic receptor ligand binding domain-like0.00000000002385Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000004388Direct
Cullin repeat-like0.00000000612Direct
Cullin homology domain0.0000005019Direct
Protein kinase-like (PK-like)0.000005404Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.00003377Direct
cAMP-binding domain-like0.00008Direct
Periplasmic binding protein-like II0.0001518Direct
Periplasmic binding protein-like I0.000255Direct
Myosin rod fragments0.002866Inherited
Transducin (alpha subunit), insertion domain0.003132Inherited
Quinoprotein alcohol dehydrogenase-like0.005708Inherited
TPR-like0.0154Inherited
Voltage-gated potassium channels0.01684Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.0177Inherited
Cysteine-rich domain0.01935Inherited
PRTase-like0.02134Inherited
ENTH/VHS domain0.02453Inherited
Multidrug efflux transporter AcrB transmembrane domain0.02861Inherited
PDZ domain-like0.03029Inherited
Spectrin repeat0.03713Inherited
Immunoglobulin0.03957Inherited
Calcium ATPase, transduction domain A0.04926Inherited
Calcium ATPase, transmembrane domain M0.04926Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.04926Inherited
Troponin coil-coiled subunits0.06756Inherited
Glutathione synthetase ATP-binding domain-like0.07687Inherited
SMAD/FHA domain0.07687Inherited
SAM/Pointed domain0.07863Inherited
Regulator of G-protein signaling, RGS0.07863Inherited
WD40 repeat-like0.09105Inherited
SH3-domain0.09895Inherited
Nucleotide cyclase0.09982Inherited
EGF/Laminin0.1183Inherited
t-snare proteins0.1217Inherited
SNARE-like0.1217Inherited
Cystine-knot cytokines0.1908Inherited
POZ domain0.2Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.2021Inherited
Lipovitellin-phosvitin complex, superhelical domain0.2021Inherited
PH domain-like0.2589Inherited
GroEL-intermediate domain like0.2602Inherited
GroEL equatorial domain-like0.2602Inherited
WW domain0.2602Inherited
GroEL apical domain-like0.2602Inherited
P-loop containing nucleoside triphosphate hydrolases0.2957Inherited
Tubulin nucleotide-binding domain-like0.3044Inherited
Sm-like ribonucleoproteins0.3121Inherited
HAD-like0.334Inherited
Bromodomain0.371Inherited
Tubulin C-terminal domain-like0.4413Inherited
"Winged helix" DNA-binding domain0.52Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.5995Inherited
ABC transporter transmembrane region0.7028Inherited
Homeodomain-like0.7884Inherited
Nucleic acid-binding proteins0.8612Inherited
DBL homology domain (DH-domain)0.8775Inherited
Leucine zipper domain0.887Inherited
HLH, helix-loop-helix DNA-binding domain0.9387Inherited
Nuclear receptor ligand-binding domain0.9789Inherited
Ankyrin repeat1Inherited
Family A G protein-coupled receptor-like1Inherited
beta-beta-alpha zinc fingers1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.00000000002529Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.00000000004388Direct
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.00000007177Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0003389Direct
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.0004507Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.0006219Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.0009528Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.003132Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.01232Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.0177Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.04926Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.06756Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.06756Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.06756Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.07687Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.2021Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.2021Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.2602Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.2602Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.3044Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.7028Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.799Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.912Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003389Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.07687Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1217Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.2021Inherited
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.2602Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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